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1,036
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ShareScore release 0.9.0
Dataset results
1,036 results for “Cell mechanics”
SOX11 Downregulation and IL-7/IL22RA2 Upregulation Might be a Potential Mechanism of Exosome in Promoting Schwann Cell Proliferation
GEO Series GSE315249. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions (6)
GEO Series GSE203188. Mus musculus. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma cells [GEP data]
GEO Series GSE29712. Homo sapiens. 6 samples. Type: Expression profiling by array.
Mechanism suppressing transcription of the globin genes in Danio rerio nonerythroid cells
GEO Series GSE154562. Danio rerio. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of resistance mechanisms to anti-HER2 antibody in breast cancer cell line BT-474
GEO Series GSE89216. Homo sapiens. 8 samples. Type: Expression profiling by array.
RNA-sequencing transcriptome analysis suggested Gdf10 expression in adventitial CFs represents a mechanism for crosstalk with a distinct cardiac cell type [human RNA-seq]
GEO Series GSE253545. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Estrogen-independent Epigenetic Mechanisms Regulate Gender Dimorphisms in Cardiac Reparative Functions of Bone Marrow Progenitor Cells
GEO Series GSE253058. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Changes in gene expression after mechanical loading with and without satellite cell.
GEO Series GSE153542. Mus musculus. 20 samples. Type: Expression profiling by array.
Novel mechanisms of galactose toxicity in human galactose-1-phosphate uridyltransferase (GALT)-deficient cells
GEO Series GSE4864. Homo sapiens. 6 samples. Type: Expression profiling by array.
Mechanical stretch promotes invasion of lung cancer cells via activation of tumor necrosis factor-alpha
GEO Series GSE214041. Homo sapiens. 2 samples. Type: Expression profiling by array.
Multi-tissue single cell profiling of genetically diverse mouse models reveals mechanisms of resilience to obesity and diabetes [snATAC_seq_adipose]
GEO Series GSE272075. Mus musculus. 21 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Osr2 functions as a mechanical checkpoint to augment CD8+ T cell exhaustion [Osr2OE_vs_Vector_ATAC_CD8]
GEO Series GSE223162. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Comprehensive transcriptome characterization deciphers mechanisms underpinning the positive selection of B cells in germinal centers.
GEO Series GSE278743. Mus musculus; Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanism of Atractylon in invasion and migration of hepatic cancer cells based on high-throughput sequencing
GEO Series GSE165941. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide profiling of microRNAs revealing novel insights into mutual interactions mechanism between H9N2 avian influenza virus and avian dendritic cells
GEO Series GSE100916. Gallus gallus. 2 samples. Type: Expression profiling by array.
Mechanical stretch differentially regulates the expression of specific miRNA in the extracellular vesicles released from lung epithelial cells
GEO Series GSE131645. Mus musculus; synthetic construct. 16 samples. Type: Non-coding RNA profiling by array.
Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1
<p>This record contains raw data related to the article "Coronary artery mechanics induces human saphenous vein remodelling via recruitment of adventitial myofibroblast-like cells mediated by Thrombospondin-1".</p> <p><strong>Rationale</strong>: Despite the preferred application of arterial conduits, the greater saphenous vein (SV) remains indispensable for coronary bypass grafting (CABG), especially in multi-vessel coronary artery disease (CAD). The objective of the present work was to address the role of mechanical forces in the activation of maladaptive vein bypass remodeling, a process determining progressive occlusion and recurrence of ischemic heart disease. <strong>Methods</strong>: We employed a custom bioreactor to mimic the coronary shear and wall mechanics in human SV vascular conduits and reproduce experimentally the biomechanical conditions of coronary grafting and analyzed vein remodeling process by histology, histochemistry and immunofluorescence. We also subjected vein-derived cells to cyclic uniaxial mechanical stimulation in culture, followed by phenotypic and molecular characterization using RNA and proteomic methods. We finally validated our results <em>in vitro</em> and using a model of SV carotid interposition in pigs. <strong>Results</strong>: Exposure to pulsatile flow determined a remodeling process of the vascular wall involving reduction in media thickness. Smooth muscle cells (SMCs) underwent conversion from contractile to synthetic phenotype. A time-dependent increase in proliferating cells expressing mesenchymal (CD44) and early SMC (SM22α) markers, apparently recruited from the SV adventitia, was observed especially in CABG-stimulated vessels. Mechanically stimulated SMCs underwent transition from contractile to synthetic phenotype. MALDI-TOF-based secretome analysis revealed a consistent release of Thrombospondin-1 (TSP-1), a matricellular protein involved in TGF-β-dependent signaling. TSP-1 had a direct chemotactic effect on SV adventitia resident progenitors (SVPs); this effects was inhibited by blocking TSP-1 receptor CD47. The involvement of TSP-1 in adventitial progenitor cells differentiation and graft intima hyperplasia was finally contextualized in the TGF-β-dependent pathway, and validated in a saphenous vein into carotid interposition pig model. <strong>Conclusions</strong>: Our results provide the evidence of a matricellular mechanism involved in the human vein arterialization process controlled by alterations in tissue mechanics, and open the way to novel potential strategies to block VGD progression based on targeting cell mechanosensing-related effectors.</p>
Dataset for Mechanically Flexible Polymeric Nanoneedle Arrays for Promoting Differentiation and Functional Activity of Neural Progenitor Cells
Open the record for dataset details and reuse information.
Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade
<p><strong>Introduction - T</strong>his database includes the raw data linked with the paper <em>Evidence for novel cell defense mechanisms sustained by dimethyl fumarate in multiple sclerosis patients: the HuR/SOD2 cascade.</em></p> <p>In this paper, we reported the HuR protein levels in peripheral blood mononuclear cells (PBMCs) from MS patients before and after dimethyl fumarate (DMF) treatment compared to healthy controls (HC). Considering that HuR may act on different targets playing a protective role against oxidative stress, we had the goal of disclosing whether MnSOD could represent a new molecular target of HuR and the potential influence of DMF treatment on this interaction .</p> <p><strong>Methods - </strong>PBMCs from 20 patients with MS and 20 matched HC were used to evaluate HuR, MnSOD and Nrf2 protein content by Western blot, before and after 12 months of DMF treatment.</p> <p>Immunoprecipitation experiments coupled with RNA extraction in PBMCs were performed to explore whether MnSOD mRNA could be physically bound by HuR and whether this binding could be affected by 12 months of DMF treatment.</p> <p><strong>Results </strong>- In PBMCs, HuR protein interacts with MnSOD transcript both in HC and in MS patients naïve to disease modifying treatment. This interaction is positively affected by 12 months of DMF treatment. PBMCs from MS patients have a lower HuR and MnSOD protein content compared to matched HC (HuR: p<0.01, MnSOD p<0.01). Of interest, 12 months of DMF treatment in MS patients restore the amount of both HuR protein and MnSOD enzyme to the levels observed in HC. We also confirmed that Nrf2 is an HuR target, and we report that its levels are significantly increased in MS patients naïve to disease modifying treatment and remain elevated following DMF administration.</p>
Osr2 functions as a mechanical checkpoint to augment CD8+ T cell exhaustion [TIL_scRNA_CD8]
GEO Series GSE223160. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.