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Dataset results
1,161 results for “Drosophila melanogaster”
Drosophila melanogaster gene expression changes after spaceflight.
GEO Series GSE23880. Drosophila melanogaster. 18 samples. Type: Expression profiling by array.
Genome-wide map of DNA Polymerase II binding in the adult Drosophila melanogaster gut in control and infected conditions
GEO Series GSE118145. Drosophila melanogaster. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Hi-C of early Drosophila melanogaster embryos
GEO Series GSE100370. Drosophila melanogaster. 9 samples. Type: Other.
Acute ethanol exposure time-course in Drosophila melanogaster
GEO Series GSE18208. Drosophila melanogaster. 16 samples. Type: Expression profiling by array.
RNA-Seq dataset from FACS-isolated L2 and T1 neurons (Drosophila melanogaster).
GEO Series GSE154085. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing.
Drosophila melanogaster CantonS blue gut larvae vs. white prepupae
GEO Series GSE130. Drosophila melanogaster. 4 samples. Type: Expression profiling by array.
H4K16ac and RNAPol2 CUT&Tag of Drosophila Melanogaster and Bacillus Grandii
GEO Series GSE306499. Drosophila melanogaster; Bacillus grandii. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Impact of nuclear Piwi elimination on chromatin state in Drosophila melanogaster ovaries
GEO Series GSE56347. Drosophila melanogaster. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
GEO Series GSE9248. Drosophila melanogaster. 8 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Expression data from transgenic Drosophila melanogaster adults which contain a knockdown effector of cyp6g1, compared to control flies
GEO Series GSE27344. Drosophila melanogaster. 14 samples. Type: Expression profiling by array.
Whole genome sequencing of Drosophila melanogaster from different microclimates at 'Evolution Canyon'
GEO Series GSE104077. Drosophila melanogaster. 32 samples. Type: Other.
Expression profiles of Drosophila melanogaster males with DX mothers and X-chromosomes that were subjected to male-limited evolution
GEO Series GSE37325. Drosophila melanogaster. 18 samples. Type: Expression profiling by array.
Gene expression analysis of Drosophila melanogaster taste tissue
GEO Series GSE19984. Drosophila melanogaster. 6 samples. Type: Expression profiling by array.
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative damage, and apoptosis, are seen only in SFμg. Additionally, progressive neuronal loss and a glial phenotype in SF1g and SFμg brains, with pronounced phenotypes in SFμg, are seen upon acclimation to Earth conditions. Overall, our results indicate that artificial gravity partially protects the CNS from the adverse effects of spaceflight. This study derives results from the in-flight video analysis (video recording assay).
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster (Immunohistochemistry)
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative damage, and apoptosis, are seen only in SFμg. Additionally, progressive neuronal loss and a glial phenotype in SF1g and SFμg brains, with pronounced phenotypes in SFμg, are seen upon acclimation to Earth conditions. Overall, our results indicate that artificial gravity partially protects the CNS from the adverse effects of spaceflight. This study derives results from the immunohistochemistry (cellular and molecular imaging) assay from whole brains.
The development of Drosophila melanogaster during space flight
In prospective human exploration of outer space the need to maintain a species over several generations under changed gravity conditions may arise. This paper reports the analysis of the third generation of fruit fly Drosophila melanogaster obtained during the 44.5-day space flight (Foton-M4 satellite 2014 Russia) followed by the fourth generation on Earth and the fifth generation under conditions of a 12-day space flight (2014 in the Russian Segment of the ISS). The obtained results show that it is possible to obtain the third-fifth generations of a complex multicellular Earth organism under changed gravity conditions (in the cycle weightlessness - Earth - weightlessness) which preserves fertility and normal development. However there were a number of changes in the expression levels and content of cytoskeletal proteins that are the key components of the spindle apparatus and the contractile ring of cells.
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster (Behavior, Climbing)
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to spaceflight microgravity (SFμg) and artificially simulated Earth gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative damage, and apoptosis, are seen only in SFμg. Additionally, progressive neuronal loss and a glial phenotype in SF1g and SFμg brains, with pronounced phenotypes in SFμg, are seen upon acclimation to Earth conditions. Overall, our results indicate that artificial gravity partially protects the CNS from the adverse effects of spaceflight. This study derives results from the climbing assay (locomotor assay).
Transcriptomic response of Drosophila melanogaster pupae developed in hypergravity
Physical forces greatly influence the growth and function of an organism. Altered gravity can perturb normal development and induce corresponding changes in gene expression. Understanding this relationship between the physical and biological realms is important for NASA's space travel goals. We use combined RNA-Seq and qRT-PCR to profile changes in early Drosophila melanogaster pupae exposed to chronic hypergravity (3 g, three times Earth's gravity) to highlight gravity-dependent pathways and gene products. Robust transcriptional response was evident among the pupae developed in a hypergravity environment compared to control. 1,513 genes showed significantly (p less than 0.05) altered gene expression in the 3 g samples. These findings were supported with qRT-PCR data. Major biological processes affected include ion transport, redox homeostasis, immune and humoral stress response, proteolysis, and cuticle development.
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster
Spaceflight poses risks to the central nervous system (CNS), and understanding neurological responses is important for future missions. We report CNS changes in Drosophila aboard the International Space Station in response to microgravity (SFμg) and artificially simulated Earth-gravity (SF1g) via inflight centrifugation as a countermeasure. While inflight behavioral analyses of SFμg exhibit increased activity, postflight analysis displays significant climbing defects, highlighting the sensitivity of behavior to altered gravity. Multi-omics analysis shows alterations in metabolic, oxidative stress, and synaptic transmission pathways in both SFμg and SF1g; however, neurological changes immediately postflight, including neuronal loss, glial cell count alterations, oxidative damage, and apoptosis, are seen only in SFμg. Additionally, progressive neuronal loss and a glial phenotype in SF1g and SFμg brains, with pronounced phenotypes in SFμg, are seen upon acclimation to Earth conditions. Overall, our results indicate that artificial gravity partially protects the CNS from the adverse effects of spaceflight.
Expression data from drosophila melanogaster
Space travel presents unlimited opportunities for exploration and discovery, but requires a more complete understanding of the immunological consequences of long-term exposure to the conditions of spaceflight. To understand these consequences better and to contribute to design of effective countermeasures, we used the Drosophila model to compare innate immune responses to bacteria and fungi in flies that were either raised on earth or in outer space aboard the NASA Space Shuttle Discovery (STS-121). Microarrays were used to characterize changes in gene expression that occur in response to infection by bacteria and fungus in drosophila that were either hatched and raised in outer space (microgravity) or on earth (normal gravity). Whole Oregon R strain drosophila melanogaster fruit flies either raised on earth or in space that were (1) uninfected, (2) infected with bacteria (Escherichia coli), or (3) infected with fungus (Beauveria bassiana) were used for RNA extraction and hybridization on Affymetrix microarrays.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.