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1,052
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Dataset results
1,052 results for “cardiomyocytes”
Cellular Heterogeneity of Pluripotent Stem Cell Derived Cardiomyocyte Grafts is Mechanistically Linked to Treatable Arrhythmias
GEO Series GSE248953. Sus scrofa; Homo sapiens. 4 samples. Type: Other; Expression profiling by high throughput sequencing.
Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers is Suppressed by a MicroRNA [ChIP-Seq]
GEO Series GSE82243. Rattus norvegicus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Changes in the transcriptome, proteome and phosphoproteome in a cardiomyocyte model of nitroxidative stress
GEO Series GSE100410. Rattus norvegicus. 12 samples. Type: Expression profiling by array.
Metabolic changes of human induced pluripotent stem cell-derived cardiomyocytes and teratomas after transplantation
GEO Series GSE279695. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Adult cardiomyocytes treated with fractalkine (CX3CL1)
GEO Series GSE7397. Rattus norvegicus. 10 samples. Type: Expression profiling by array.
YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes
GEO Series GSE261296. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiling of human-derived primary cardiomyocytes with lncRNA ZNF593-AS 5‘ end overexpression under phenylephrine stimulation
GEO Series GSE163645. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
H3K9me3 and H3K27me3 genomic occupancy on neonatal mouse cardiomyocytes (CMs) treated with PBS/phenylephrine (PE) and lincRNA-p21 WT/knockdown
GEO Series GSE262936. Mus musculus. 20 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers is Suppressed by a MicroRNA
GEO Series GSE83230. Rattus norvegicus. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Secreted-frizzled-related protein 5 modulates calcium handling in human iPSC-cardiomyocytes
GEO Series GSE240053. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
A Human Embryonic Stem Cell Reporter Line for Studying Cardiomyocyte Biology
GEO Series GSE111365. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Effects of DECR1 deletion on cardiomyocytes
GEO Series GSE308744. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement"
<p>This record contains raw data related to the article "Evidence of SARS-CoV-2 transcriptional activity in cardiomyocytes of COVID-19 patients without clinical signs of cardiac involvement"</p> <p> </p> <p>Article abstract:</p> <p><strong>Abstract:</strong> <strong>Aims: </strong>A considerable proportion of patients affected by coronavirus respiratory disease (COVID-19) develop cardiac injury. The viral impact in cardiomyocytes deserves, however, further investigations, especially in asymptomatic patients. <strong>Methods: </strong>We investigated for SARS-CoV-2 presence and activity in heart tissues of 6 consecutive COVID-19 patients deceased for respiratory failure showing no signs of cardiac involvement and with no history of heart disease. Cardiac autopsy samples were collected within 2 hours after death, and then analysed by digital PCR, Western blot, immunohistochemistry, immunofluorescence, RNAScope, and transmission electron microscopy assays. <strong>Results</strong>: The presence of SARS-CoV-2 into cardiomyocytes was invariably detected in all assays. A variable pattern of cardiomyocytes injury was observed, spanning from absence of cell death and subcellular alterations hallmarks, to intracellular oedema and sarcomere ruptures. In addition, we found active viral transcription in cardiomyocytes, by detecting both sense and antisense SARS-CoV-2 spike RNA. <strong>Conclusions: </strong>In this autopsy cases analysis of patients with no clinical signs of cardiac involvement, the presence of SARS-CoV-2 into cardiomyocytes has been detected, determining variable patterns of intracellular damage. These findings suggest the need of a cardiologic surveillance in survived COVID-19 patients not displaying a cardiac phenotype<em>.</em></p>
Up-regulation of miR-208a aggravates high-fat diet-induced cardiomyocytes injury by targeting IRS-2/PI3K/AKT pathway
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Dataset related to the article "Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation"
<p>This record contains raw data related to the article “Modeling Cardiomyopathies in a Dish: State-of-the-Art and Novel Perspectives on hiPSC-Derived Cardiomyocytes Maturation".</p> <p>Abstract</p> <p>The stem cell technology and the induced pluripotent stem cells (iPSCs) production represent an excellent alternative tool to study cardiomyopathies, which overcome the limitations associated with primary cardiomyocytes (CMs) access and manipulation. CMs from human iPSCs (hiPSC-CMs) are genetically identical to patient primary cells of origin, with the main electrophysiological and mechanical features of CMs. The key issue to be solved is to achieve a degree of structural and functional maturity typical of adult CMs. In this perspective, we will focus on the main differences between fetal-like hiPSC-CMs and adult CMs. A viewpoint is given on the different approaches used to improve hiPSC-CMs maturity, spanning from long-term culture to complex engineered heart tissue. Further, we outline limitations and future developments needed in cardiomyopathy disease modeling.</p>
cardiomyocyte induced from fibroblast
GEO Series GSE32605. Mus musculus. 18 samples. Type: Expression profiling by array.
Del Nido Cardioplegia or Potassium Induces Nrf2 and Protects Cardiomyocytes Against Oxidative Stress
GEO Series GSE221058. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-binding protein with multiple splicing (Rbpms) contributes to noncompaction cardiomyopathy by regulating cardiomyocyte cytokinesis and binucleation
GEO Series GSE182949. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression data from neonatal mice cardiomyocytes
GEO Series GSE80199. Mus musculus. 6 samples. Type: Expression profiling by array.
Glycine Promotes Cardiomyocyte Proliferation and Cardiac Regeneration via the GCN2/AKT Axis
GEO Series GSE318305. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.