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1,102
datasets available to search
ShareScore release 0.9.0
Dataset results
1,102 results for “human use”
Identification of human glucocorticoid response markers using integrated multi-omic analysis [Peripheral blood mononuclear cells]
GEO Series GSE148639. Homo sapiens. 18 samples. Type: Expression profiling by array.
Transcriptional profiling of human prefrontal cortex using single cell/nuclei and bulk RNAseq
GEO Series GSE225081. Homo sapiens. 7 samples. Type: Expression profiling by high throughput sequencing.
Bridging the gap of late-gestation nephrogenesis using a non-human primate model
GEO Series GSE305708. Macaca mulatta. 5 samples. Type: Expression profiling by high throughput sequencing.
Evaluation and mechanism study of cardiotoxicity caused by antipsychotics using human-induced pluripotent stem cell-derived cardiomyocytes
GEO Series GSE248368. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
A Hightroughput Approach for Screening Potential Green Plasticizers Using A Human Prostate Cell Line [set3]
GEO Series GSE67398. Homo sapiens. 20 samples. Type: Expression profiling by array.
Profiling transcriptional and translational response to anoxia or hypoxia of genes in DNA damage response and repair pathways in human fibroblast and prostate cancer cells using NanoString nCounter.
GEO Series GSE52461. Homo sapiens. 16 samples. Type: Expression profiling by array.
Modulation of ER Stress in Human Type 1 Diabetic Islets Through Combined Use of Stress Inducer and Inhibitor Treatments
GEO Series GSE275138. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
A Platform to Define Cellular Targets of SARS-COV-2 Infection Using Human Pluripotent Stem Cell-Derived Cells and Organoids
GEO Series GSE147903. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq data for KRAS wild-type(WT) and two mutant forms G12V and Q61H over-expressed samples with green fluorescent protein control samples using human mammary epithelial cells
GEO Series GSE76877. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Reconstitution of human adrenocortical specification and steroidogenesis using induced pluripotent stem cells [scRNA-seq]
GEO Series GSE201794. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome wide high throughput mapping of protein-RNA interactions across human cell lines using POP-seq
GEO Series GSE198655. Homo sapiens. 16 samples. Type: Other.
Genomic profiling of typical and atypical chronic lymphocytic leukemia patients using Agilent Whole Human Genome microarrays
GEO Series GSE24823. Homo sapiens. 40 samples. Type: Genome variation profiling by array; Genome variation profiling by genome tiling array.
Toxicity Evaluation of Glyphosate and Its Formulation Adjuvant, Polyoxyethylene Tallow Amine (POEA) on Cardiogenesis Using a Novel Human Heart Organoid Model
GEO Series GSE241360. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Results of differentially expressed lncRNAs in COPD and healthy smoker using the Arraystar Human LncRNA Microarray
GEO Series GSE107426. Homo sapiens. 2 samples. Type: Expression profiling by array.
Optogenetic control of Wnt signaling models cell-intrinsic embryogenic patterning using 2D human pluripotent stem cell culture
GEO Series GSE137289. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Database publication - To Replicate, or Not to Replicate? The Creation, Use, and Dissemination of 3D Models of Human Remains: A Case Study from Portugal, Heritage 2022, 5,
<p>This database contains the data used in the manuscript - Alves-Cardoso, F.A.; Campanacho, V. To Replicate, or Not to Replicate? The Creation, Use, and Dissemination of 3D Models of Human Remains: A Case Study from Portugal. <em>Heritage </em><strong>2022</strong>, <em>5</em></p> <p>Abstract:</p> <p>Advancements in digital technology have conquered a place in cultural heritage. The widespread use of three-dimensional scanners in bioanthropology have increased the production of 3D digital replicas of human bones that are freely distributed online. However, ethical considerations about such 3D models have not reached Portuguese society, making it impossible to assess their societal impact and people’s perception of how these models are created and used. Therefore, Portuguese residents were asked to take part in an online survey. The ratio of male to female participants was 0.5:1 in 312 contributors. The age ranged between 18 and 69 years. The majority had a higher education degree. Only 43% had seen a 3D model, and 43% considered the 3D replicas the same as real bone. Also, 87% would be willing to allow their skeleton and family members to be digitalized after death, and 64% advocated the controlled dissemination of replicas through registration and login and context description association (84%). Overall, the results suggest agreement in disseminating 3D digital replicas of human bones. On a final note, the limited number of participants may be interpreted as a lack of interest in the topic or, more importantly, a low self-assessment of their opinion on the subject.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Dataset related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists"
<p>This record contains new data related to article "An in vitro model for osteoarthritis using long-cultured inflammatory human macrophages repeatedly stimulated with TLR agonists".</p> <p>Osteoarthritis (OA) is characterized by an abundance of inflammatory M1-like macrophages damaging local tissues. The search of new potential drugs for OA suffers from the lack of appropriate methods of long-lasting inflammation. Here we developed and characterized an <em>in vitro</em> protocol of long-lasting culture of primary human monocyte-derived macrophages differentiated with a combination of M-CSF+GM-CSF that optimally supported long-cultured macrophages (LC-Mfs) for up to 15 days, unlike their single use. Macrophages repeatedly stimulated for 15 days with the TLR2 ligand Pam3CSK4 (LCS-Mfs), showed sustained levels over time of IL-6, CCL2 and CXCL8, inflammatory mediators that were also detected in the synovial fluids of OA patients. Furthermore, macrophages isolated from the synovia of two OA patients showed an expression profile of inflammation-related genes similar to that of LCS-Mfs, validating our protocol as a model of chronically activated inflammatory macrophages. Next, to confirm that these LCS-Mfs could be modulated by anti-inflammatory compounds, we employed Dexamethasone and/or Celecoxib, two drugs widely used in OA treatment, that significantly inhibited the production of inflammatory mediators. This easy-to-use in vitro protocol of long-lasting inflammation with primary human macrophages could be useful for the screening of new compounds to improve the therapy of inflammatory disorders.</p>
Fostemsavir Compassionate Use Named Patient Program for the Treatment of Human Immunodeficiency Virus 1 (HIV-1)
ClinicalTrials.gov study NCT04233047. IPD Sharing: Not stated. Countries: 0. Publications: 0.
RNA-Seq is used to facilitate the identification of the BCR-ABL1- independent mechanism of resitance to imatinib using a human chronic myeloid leukaemia cell line model
GEO Series GSE149623. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.