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1,274 results for “Disease Model”
Data from: Sensory-Behavioral Deficits in Parkinson's Disease: Insights from a 6-OHDA Mouse Model
<table> <tbody> <tr> <td>Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons in the striatum, predominantly associated with motor symptoms. However, non-motor deficits, particularly sensory symptoms, often precede motor manifestations, offering a potential early diagnostic window. The impact of non-motor deficits on sensation behavior and the underlying mechanisms remains poorly understood. In this study, we examined changes in tactile sensation within a Parkinsonian state by employing a mouse model of PD induced by 6-hydroxydopamine (6-OHDA) to deplete striatal dopamine (DA). Leveraging the conserved mouse whisker system as a model for tactile-sensory stimulation, we conducted psychophysical experiments to assess sensory-driven behavioral performance during a tactile detection task in both the healthy and Parkinson-like states. Our findings reveal that DA depletion induces pronounced alterations in tactile sensation behavior, extending beyond expected motor impairments. We observed diverse behavioral deficits, spanning detection performance, task engagement, and reward accumulation, among lesioned individuals. While subjects with extreme DA depletion consistently showed severe sensory behavioral deficits, others with substantial DA depletion displayed minimal changes in sensory behavior performance. Moreover, some exhibited moderate degradation of behavioral performance, likely stemming from sensory signaling loss rather than motor impairment. The implementation of a sensory detection task is a promising approach to quantify the extent of impairments associated with DA depletion in the animal model. This facilitates the exploration of early non-motor deficits in PD, emphasizing the importance of incorporating sensory assessments in understanding the diverse spectrum of PD symptoms.</td> </tr> </tbody> </table>
Screenshots of AGC-MAC: A Conceptual Model-based Platform for the Management and Analysis of Clinical Data of Retina-Macula Diseases
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External Validation of Ischemia and Hemorrhage Risk Models in Patients With Coronary Heart Disease
ClinicalTrials.gov study NCT07295665. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Establish the Caring Model of Children With Chronic Kidney Disease and End-stage Renal Disease: To Set up Childhood Glomerular Filtration Rate (GFR) Formula in Taiwan
ClinicalTrials.gov study NCT01250626. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
ClinicalTrials.gov study NCT07311954. IPD Sharing: NO. Countries: 0. Publications: 0.
A Pharmacokinetic-pharmacodynamic Modeling and Simulation Study of Subcutaneous Infliximab in Patients With Inflammatory Bowel Disease
ClinicalTrials.gov study NCT07120152. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Real Time Early Warning Model and Mobile Medical Assistant System for the Impact of Air Pollution on AECOPD Disease
ClinicalTrials.gov study NCT04960410. IPD Sharing: NO. Countries: 0. Publications: 0.
Using Dry Eye As a Disease Model, Investigators Demonstrated the Optimal Selection of Individualized Clinical Interventions and the Superiority of Dynamic Treatment Discrimination in Chinese Medicine.
ClinicalTrials.gov study NCT06605495. IPD Sharing: NO. Countries: 0. Publications: 0.
The Effect of Chronic Care Model Based Education on Disease Management in Hypertensive Patients
ClinicalTrials.gov study NCT04411355. IPD Sharing: YES. Countries: 0. Publications: 0.
Prognostic Model of HCV-related Disease Progression After DAAs
ClinicalTrials.gov study NCT04631640. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Identification of genes associated with breast cancer micrometastatic disease in bone marrow using a Patient Derived Xenograft mouse model
GEO Series GSE57947. Homo sapiens; Mus musculus. 11 samples. Type: Expression profiling by array.
Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in a rotenone rat model of Parkinson’s disease [RNA-Seq]
GEO Series GSE280520. Rattus norvegicus. 36 samples. Type: Expression profiling by high throughput sequencing.
Anti-CX3CL1 (fractalkine) monoclonal antibody attenuates lung and skin fibrosis in sclerodermatous graft-versus-host disease mouse model
GEO Series GSE227285. Mus musculus. 19 samples. Type: Expression profiling by high throughput sequencing.
Limited effects of an eIF2αS51A allele on neurological impairments in the 5xFAD mouse model of Alzheimer’s disease
GEO Series GSE50521. Mus musculus. 12 samples. Type: Expression profiling by array.
Phenotypic and genomic analysis of multiple myeloma minimal residual disease clonal plasma cells: a new model to understand chemoresistance [HuGene-1_0 Expression]
GEO Series GSE70398. Homo sapiens. 14 samples. Type: Expression profiling by array.
Contribution of Nuclear and Extranuclear PolyQ to Neurological Phenotypes in Mouse Models of Huntington’s Disease
GEO Series GSE3248. Mus musculus. 48 samples. Type: Expression profiling by array.
Partial phenotypic rescue of the Sesb1 mitochondrial ANT1 disease model in Drosophila
GEO Series GSE55187. Drosophila melanogaster. 14 samples. Type: Expression profiling by array.
Nigral Transcriptomic Profiles in Engrailed-1 Hemizygous Mouse Models of Parkinson’s Disease Reveal Upregulation of Oxidative Phosphorylation-Related Genes Associated with Resistance to Dopaminergic N
GEO Series GSE236461. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome profiling in knock-in mouse models of Huntington's disease [Cerebellum_miRNA]
GEO Series GSE78790. Mus musculus. 96 samples. Type: Expression profiling by high throughput sequencing.
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcome in a Parkinson's disease model
GEO Series GSE204795. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.