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1,161 results for “Drosophila melanogaster”
Drosophila melanogaster gene expression changes after spaceflight.
Gene expression levels were determined in 3rd instar and adult Drosophila melanogaster reared during spaceflight, to elucidate the genetic and molecular mechanisms underpinning the effects of microgravity on the immune system. The goal was to validate the Drosophila model for understanding alterations of innate immune responses in humans due to spaceflight. Five containers of flies, with ten female and five male fruit flies in each container, were housed and bred on the space shuttle (average orbit altitude of 330.35 km) for 12 days and 18.5 hours, with a new generation reared in microgravity. RNA was extracted on the day of shuttle landing from whole body animals (3rd instar larvae and adults), hybridized to Drosophila 2.0 Affymetrix genome arrays, and the expression level of all genes was normalized against the gene expression level from the corresponding developmental stage animals raised on ground. Spaceflight altered the expression of larval genes involved in the maturation of plasmatocytes (macrophages) and their phagocytic response, as well as the level of constitutive expression of pattern recognition receptors and opsonins that specifically recognize bacteria, and of lysozymes, antimicrobial peptide pathway and immune stress genes, hallmarks of humoral immunity. Larval microarrays (FL 6 samples) are based on RNA extracted from 6 independent sets of 50 mid 3rd instar larvae reared in microgravity and collected on the day of landing after 12 days and 18.5 hours on the space shuttle and the same number of control larvae raised on ground (GL 6 samples). Adults microarrays (F1 3 samples) are based on RNA from 3 sets of 20 adult females each, that emerged during spaceflight and within 4 hours of landing and the same number of adult females from the corresponding ground control containers (G1 3 samples).
Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model
While it has been shown that astronauts suffer immune disorders after spaceflight, the underlying causes are still poorly understood and there are many variables to consider when investigating the immune system in a complex environment. Additionally, there is growing evidence that suggests that not only is the immune system being altered, but the pathogens that infect the host are significantly influenced by spaceflight and ground-based spaceflight conditions. In this study, we demonstrate that Serratia marcescens (strain Db11) was significantly more lethal to Drosophila melanogaster after growth on the International Space Station than ground-based controls, but that the host immune system is not significantly altered amongst known immune genes. High-throughput sequencing of wild-type (w1118) adult hosts infected with either space or ground-reared S. marcescens revealed few changes in gene expression, with 11 genes significantly differentially expressed (q-values less than 0.05) and only one gene related to the immune system. This data supports the main findings of the paper, which state that both spaceflight and low-shear modeled microgravity conditions increase the virulence of this pathogen, independent of the host immune system. This data, which shows that there are no significant immune-related changes to the host when infected with space-grown sample compared to ground-grown sample, provides further evidence that there are likely phenotypic changes to the pathogen itself that is causing increased virulence in spaceflight and in low-shear modeled microgravity. RNA was extracted in triplicate from 2 pooled adult (2-3 day old female) Drosophila melanogaster (w1118) per treatment, with 4 total treatment groups (no injection control, sham injection with PBS, ground bacteria-injected, and space bacteria-injected) with poly(A)+ RNA libraries. Samples were multiplexed and sequenced 100bp paired-end ready were sequenced on one lane of the Illumina HiSeq-4000.
Identification of systemic injury response genes in Drosophila melanogaster
GEO Series GSE94938. Drosophila melanogaster. 2 samples. Type: Expression profiling by array.
Drosophila melanogaster late embryo, larval, pupal and adult head small RNA libraries
GEO Series GSE12840. Drosophila melanogaster. 11 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Gene expression in Drosophila melanogaster in response to bacterial infection
GEO Series GSE216042. Drosophila melanogaster. 20 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of head tissue from Drosophila melanogaster Wild Type and Adar5G1 mutant
GEO Series GSE128332. Drosophila melanogaster. 6 samples. Type: Expression profiling by high throughput sequencing.
Drosophila melanogaster Canton-S small RNA sequence: Adult Male Head
GEO Series GSE40034. Drosophila melanogaster. 2 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Genome-wide examination of the transcriptional response to ecdysteroids 20-hydroxyecdysone and ponasterone A in Drosophila melanogaster
GEO Series GSE23928. Drosophila melanogaster. 21 samples. Type: Expression profiling by array.
8-miR cluster deletion affects mef2 levels in Drosophila melanogaster
GEO Series GSE28604. Drosophila melanogaster. 4 samples. Type: Expression profiling by array.
Drosophila melanogaster Mutated in its GBA1b Ortholog Recapitulates Neuronopathic Gaucher Disease
GEO Series GSE142144. Drosophila melanogaster. 30 samples. Type: Expression profiling by high throughput sequencing.
Identification of the genes regulated by maternal Ovo-B in PGCs in Drosophila melanogaster.
GEO Series GSE81857. Drosophila melanogaster. 6 samples. Type: Expression profiling by array.
microRNA expression profiling of Drosophila melanogaster peripheral sensory neurons.
GEO Series GSE83609. Drosophila melanogaster. 9 samples. Type: Non-coding RNA profiling by array.
Genomic distribution of the cohesin subunit Stromalin (SA) in wild-type and Haspin knock-down Drosophila melanogaster Kc167 cells
GEO Series GSE118813. Drosophila melanogaster. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis.
Transcriptional profiling of adult mushroom body neurons and whole head extracts of Drosophila melanogaster [Timecourse_RNA_Naive_Trx]
GEO Series GSE274348. Drosophila melanogaster. 30 samples. Type: Expression profiling by high throughput sequencing.
Hsp70 affects memory formation and behaviourally relevant gene expression in Drosophila melanogaster.
GEO Series GSE152647. Drosophila melanogaster. 32 samples. Type: Expression profiling by high throughput sequencing.
mRNA sequence of individual Drosophila melanogaster (w1118) male and female flies fed with different concentrations of dimethyl sulfoxide (DMSO) over different time periods.
GEO Series GSE81142. Drosophila melanogaster. 96 samples. Type: Expression profiling by high throughput sequencing.
Genome wide distribution of gammaH2AvD in Wild Type and RNAi dH1 Drosophila melanogaster S2 cells
GEO Series GSE76912. Drosophila melanogaster. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genetic and Genomic Analyses of Drosophila melanogaster Models of Chromatin Modification Disorders
GEO Series GSE213763. Drosophila melanogaster. 42 samples. Type: Expression profiling by high throughput sequencing.
Lead (Pb+2) effects in global gene expression in the larval brain of Drosophila melanogaster
GEO Series GSE77417. Drosophila melanogaster. 4 samples. Type: Expression profiling by array.
RNA-Seq of head tissue from Drosophila melanogaster Wild Type and AdarEA mutant
GEO Series GSE86054. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
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