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1,047 results for “constraint”
Transcriptional constraint of EWS/FLI by an ETS transcription factor promotes Ewing sarcoma growth [CUT&RUN]
GEO Series GSE211852. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data and Script for Network nestedness in primates: a structural constraint or a biological advantage of social complexity?
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Evaluation of the role of functional constraints on the integrity of an ultra conserved region in the genus Drosophila
GEO Series GSE31120. Drosophila melanogaster. 36 samples. Type: Expression profiling by array.
Constraint-Induced Movement Therapy in multiple sclerosis
<p>Dataset related to the journal articole </p> <p>"Constraint-Induced Movement Therapy in multiple sclerosis"</p> <p>de Sire Alessandro, Bigoni Matteo, Priano Lorenzo, Baudo Silvia, Solaro Claudio, MAURO ALESSANDRO</p> <p>NeuroRehabilitation 2019;45(2):247-254.</p>
ConBatch-BAL: Batch Bayesian Active Learning under Budget Constraints. Datasets, Benchmark Results, and Torch Files.
<div> <div># ConBatch-BAL: Batch Bayesian Active Learning under Budget Constraints. Datasets, Benchmark Results, and Torch Files.</div> <br> <div>## Table of Contents</div> <br> <div>- [Overview](#overview)</div> <div>- [Folder Structure](#folder-structure)</div> <div>- [Contents](#contents)</div> <div>- [Licenses](#licenses)</div> <br> <div>## Overview</div> <div>This project contains three datasets along with stored results from the conducted benchmark analysis and torch files for running or reproducing active learning experiments.</div> <br> <div>## Folder Structure</div> <br> <div>```plaintext</div> <div>conBatchBAL_datasets/</div> <div>├── benchmark_results/</div> <div>├── benchmark_torch_files/</div> <div>├── build6k/</div> <div>├── mnist6k/</div> <div>└── nieman17k/</div> <div>```</div> <br> <div>## Contents:</div> <div>- benchmark_results/: This directory contains the results and config files for reproducing the experiments presented in the paper.</div> <br> <div>- benchmark_torch_files/: This folder contains the required torch (and json) files to run/reproduce active learning experiments.</div> <br> <div>- build6k/: This folder contains approximately 6000 aerial images of buildings in Rotterdam with their corresponding energy efficiency class and geolocation.</div> <br> <div>- mnist6k/: This folder contains approximately 6000 images of digits *artificially* geolocated in Rotterdam. The geolocations correspond to the buildings contained on the *build6k* dataset.</div> <br> <div>- nieman17k/: This folder contains approximately 17000 aerial images of buildings in Rotterdam with their corresponding typology class and geolocation.</div> <br> <div>**Additional readme files are included in each directory.**</div> <br> <div>## Licenses</div> <br> <div>- build6k/</div> <div>The build6k dataset is released under the Creative Commons Attribution 4.0 International (CC BY 4.0) [LICENSE](https://creativecommons.org/licenses/by/4.0/), allowing for use, distribution, and modifications with proper attribution.</div> <br> <div>- mnist6k/</div> <div>The mnist6k dataset is released under the CC BY-SA 3.0 [LICENSE](https://creativecommons.org/licenses/by-sa/3.0/).</div> <br> <div>- nieman17k/</div> <div>The nieman17k dataset is released under the Creative Commons Attribution 4.0 International (CC BY 4.0) [LICENSE](https://creativecommons.org/licenses/by/4.0/), allowing for use, distribution, and modifications with proper attribution.</div> <br> <div>- Benchmark Results and Torch Files</div> <div>The benchmark results and Torch files generated as part of this project are released under the Creative Commons Attribution 4.0 International (CC BY 4.0) [LICENSE](https://creativecommons.org/licenses/by/4.0/), allowing for use, distribution, and modifications with proper attribution.</div> <br> <div>**License details are included separately in each directory**</div> </div>
Data from: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
<p>A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardiotonic steroids (CTS) across tetrapods, which occurs via specific amino acid substitutions to the α-subunit family of Na,K-ATPases (ATP1A). After identifying a series of recurrent substitutions at two key sites of ATP1A that are predicted to confer CTS resistance in diverse tetrapods, we then performed protein engineering experiments to test the functional consequences of introducing these substitutions onto divergent species backgrounds. In line with previous results, we find that substitutions at these sites can have substantial background-dependent effects on CTS resistance. Globally, however, these substitutions also have pleiotropic effects that are consistent with additive rather than background-dependent effects. Moreover, the magnitude of a substitution's effect on activity does not depend on the overall extent of ATP1A sequence divergence between species. Our results suggest that epistatic constraints on the evolution of CTS-resistant forms of Na,K-ATPase likely depend on a small number of sites, with little dependence on overall levels of protein divergence. We propose that dependence on a limited number sites may account for the observation of convergent CTS resistance substitutions observed among taxa with highly divergent Na,K-ATPases.</p>
Data from: Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.