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1,084
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ShareScore release 0.9.0
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1,084 results for “substrate”
Substrate selectivity of semisynthetic Akt with pSer473 or O-GlcNAcSer473
GEO Series GSE181983. Homo sapiens; synthetic construct. 6 samples. Type: Protein profiling by protein array.
Source data for neurite outgrowth assay for the: NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease
<p><strong>Neurite outgrowth assay:</strong> 1x10<sup>5</sup> neurons were plated into XONA-microfluidic chambers (standard neuron device, SND450) that had been placed on PDL coated coverslips, according to the manufacturers’ instructions. After 4h the plated cells were infected with the respective viruses (scr. shRNA-EGFP control, or NrCAM shRNA-EGFP, 1:1000). Cells were kept until DIV3 at 37°C and 5% CO<sub>2</sub>, and then the first photomicrographs of the fluorescent neurons were taken with a Leica DM6000 inverted microscope. The images covered the whole channel area in the middle of the respective chambers. Afterwards, the neurons were treated with GI254023x (5 µM), or vehicle and kept at 37°C and 5% CO<sub>2</sub> for 24h. At DIV4, a second set of photomicrographs of the same areas were taken and analyzed for length differences of single neurites (length in mm at 24h-0h) with Leica LASX software. Only neurites that had already entered and not yet left the channels on the other side at the timepoint 0h were used for the calculation. When neurites were separating after leaving the main channel the longest process was quantified.</p> <p> </p>
Phosphatidylinositol 4,5-bisphosphate (PIP2) facilitates norepinephrine transporter dimerization and modulates substrate efflux
<p>Source data supporting the findings of the study.</p>
Longer is better - the functional benefit of long tails in limbless lizards: evidence from locomotion through contrasting substrates in a pygopodid legless lizard
<p>Limbless vertebrates display a variety of morphologies, which are often linked to a species’ ecology and locomotion. Pygopodids, limbless gekkotans endemic to the Australo-Papuan region, exemplify a spectrum of ecomorphological variation in relative body-to-tail lengths. <em>D</em><em>elma molleri</em> inhabits grasslands and represents the short-bodied and long-tailed ecomorph. We predicted that its locomotor performance would be enhanced on grass substrates as opposed to structurally simpler substrates. To test this hypothesis, we assessed locomotion of <em>D. molleri </em>through three ecologically relevant substrates. Locomotor performance was significantly faster on the grass substrate over multiple distances. These data provide evidence of a functional performance benefit for limbless lizards with short bodies and long tails in grassy habitats, supports theories that such a morphology may have evolved to suit the occupation of these environments, and provide the first evidence of the functional benefit of long tails for locomotion through grass in a member of the Pygopodidae.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.