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2,552 results for “Glioblastoma”
TREM2 inhibition triggers anti-tumor cell activity of myeloid cells in glioblastoma
GEO Series GSE226293. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Ultrasonic surgical aspirate is a reliable source for culturing glioblastoma stem cells
GEO Series GSE84707. Homo sapiens. 12 samples. Type: Expression profiling by array.
Knockdown of NAT12/NAA30 decreases glioblastoma stem cell growth and tumorigenicity by regulating hypoxia response, p-MTOR (Ser2448) and p53 pathway
GEO Series GSE60706. Homo sapiens. 12 samples. Type: Expression profiling by array.
Distinct cell adhesion signature defines glioblastoma myeloid-derived suppressor cell subsets
GEO Series GSE206551. Mus musculus. 16 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: NF1-glioblastoma clonal profiling reveals KMT2B mutations as potential somatic oncogenic events
none
Data from: Diffusion tensor imaging in patients with glioblastoma multiforme using the supertoroidal model
Purpose: Diffusion Tensor Imaging (DTI) is a powerful imaging technique that has led to improvements in the diagnosis and prognosis of cerebral lesions and neurosurgical guidance for tumor resection. Traditional tensor modeling, however, has difficulties in differentiating tumor-infiltrated regions and peritumoral edema. Here, we describe the supertoroidal model, which incorporates an increase in surface genus and a continuum of toroidal shapes to improve upon the characterization of Glioblastoma multiforme (GBM). Materials and Methods: DTI brain datasets of 18 individuals with GBM and 18 normal subjects were acquired using a 3T scanner. A supertoroidal model of the diffusion tensor and two new diffusion tensor invariants, one to evaluate diffusivity, the toroidal volume (TV), and one to evaluate anisotropy, the toroidal curvature (TC), were applied and evaluated in the characterization of GBM brain tumors. TV and TC were compared with the mean diffusivity (MD) and fractional anisotropy (FA) indices inside the tumor, surrounding edema, as well as contralateral to the lesions, in the white matter (WM) and gray matter (GM). Results: The supertoroidal model enhanced the borders between tumors and surrounding structures, refined the boundaries between WM and GM, and revealed the heterogeneity inherent to tumor-infiltrated tissue. Both MD and TV demonstrated high intensities in the tumor, with lower values in the surrounding edema, which in turn were higher than those of unaffected brain parenchyma. Both TC and FA were effective in revealing the structural degradation of WM tracts. Conclusions: Our findings indicate that the supertoroidal model enables effective tensor visualization as well as quantitative scalar maps that improve the understanding of the underlying tissue structure properties. Hence, this approach has the potential to enhance diagnosis, preoperative planning, and intraoperative image guidance during surgical management of brain lesions.
Unveiling Therapeutic Targets and Immunological Insights in Glioblastoma Through Analysis of Glioma-Associated Mesenchymal Stem Cells
<p>To analyze the binding affinities and interaction modes between the drug candidates and their targets, we employed the Autodock Vina software [21]. Molecular structures of the candidate drugs and targets of hub genes were retrieved from Pubchem (https://pubchem.ncbi.nlm.nih.gov/) and Protein Data Bank database (http://www.rcsb.org/), respectively. <span>In the analysis of docking, the files for all proteins and molecules were converted to PDBQT format. Water molecules were removed and polar hydrogen atoms were added. The grid box was positioned at the center to encompass the protein domain, allowing for unrestricted movement of molecules.</span></p>
Joint analysis of single-cell RNA sequencing and bulk transcriptome reveals the heterogeneity of the urea cycle of astrocytes in glioblastoma
Open the record for dataset details and reuse information.
The PRECISE Trial: Study of IL13-PE38QQR Compared to GLIADEL Wafer in Patients With Recurrent Glioblastoma Multiforme
ClinicalTrials.gov study NCT00076986. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Combined Approach to Resection of Glioblastoma (GBM) by 5-Aminolevulinic Acid (5-ALA) and Intraoperative Magnetic Resonance Imaging (MRI)
ClinicalTrials.gov study NCT01208909. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adjuvant Temozolomide ± 5-Aminolevulinic Acid + Low Intensity Diffuse Ultrasound Sonodynamic Therapy System for Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT07225621. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma
ClinicalTrials.gov study NCT03535350. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase 0/1 Study of BDTX-1535 in Recurrent High-Grade Glioma (rHGG) and Newly Diagnosed Glioblastoma (nGBM) Participants With EGFR Alterations or Fusions
ClinicalTrials.gov study NCT06072586. IPD Sharing: NO. Countries: 1. Publications: 0.
The Safety and Efficacy of SNC-109 CAR-T Cells Therapy the Recurrent Glioblastoma
ClinicalTrials.gov study NCT05868083. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Prognostic Biomarkers of Survival at 6 Months for Patients Treated With Bevacizumab Glioblastomas in First Relapse After Failure of Radiochemotherapy
ClinicalTrials.gov study NCT03144167. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Stereotactic Radiosurgery With Nivolumab and Valproate in Patients With Recurrent Glioblastoma
ClinicalTrials.gov study NCT02648633. IPD Sharing: NO. Countries: 1. Publications: 0.
Tipifarnib and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme
ClinicalTrials.gov study NCT00058097. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Response Monitoring Trial in Patients With Suspected Recurrence of Glioblastoma
ClinicalTrials.gov study NCT02176720. IPD Sharing: NO. Countries: 1. Publications: 0.
Combination Chemotherapy in Treating Patients With Recurrent Glioblastoma Multiforme
ClinicalTrials.gov study NCT00014105. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Atezolizumab and Cabozantinib for the Treatment of Recurrent Glioblastoma
ClinicalTrials.gov study NCT05039281. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.