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1,335 results for “Oxidative stress.”
Dataset related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"
<p>This record contains raw data related to the article "MiRNA profiling revealed enhanced susceptibility to oxidative stress of endothelial cells from bicuspid aortic valve"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aims</p> <p>Calcific <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-stenosis">aortic valve stenosis</a> (CAVS) is the most frequent manifestation of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve-disease">aortic valve disease</a> and the third leading cause of cardiovascular disease in the Western countries associated with significant morbidity and mortality. An active biological progression involving inflammation and <a href="https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/alpha-oxidation">oxidation</a> leading to valve endothelial damage is considered a hallmark of the early stages of valve degeneration. However, tricuspid (TAV) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/premolar">bicuspid</a> (BAV) <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/aortic-valve">aortic valve</a> deterioration are considered to differ only by shear stress. We hypothesized that <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/endothelial-cell">endothelial cells</a> (EC) derived from BAV and TAV patients have different <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNA</a> expression patterns and thus distinct pathways could lead to endothelial damage in BAV than TAV patients.</p> <p>Methods and results</p> <p>We isolated ECs from patients with bicuspid or tricuspid aortic valve, which underwent surgery due to CAVS. MiRNA expression profile by PCR revealed eight upregulated <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/microrna">miRNAs</a> between BAV and TAV ECs. Functional analysis identified that BAV ECs presented altered cellular response to <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/oxidative-stress">oxidative stress</a> and DNA damage stimulus <em>via</em> <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/protein-p53">p53</a> and alteration in the intrinsic apoptotic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/signal-transduction">signaling pathway</a>. <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/gpx3">GPX3</a> and SRXN1 <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/messenger-rna">mRNA</a> were express at lower levels in BAV compared to TAV ECs, leading to an increment of <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/double-stranded-dna">DNA double-strand</a> breaks. BAV ECs had a sustained <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/programmed-cell-death">apoptosis</a> activation when compared to TAV ECs. This difference was exacerbated by oxidative stress stimulus leading to a reduced survival rate but completely reverted by miR-328-3p inhibition.</p> <p>Conclusion</p> <p>The present data showed molecular differences in oxidative stress susceptibility, DNA damage magnitude, and apoptosis induction between ECs derived from BAV and TAV patients.</p>
Dataset related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"
<p>This record contains raw data related to the article "Impact of Oxidative Stress and Protein S-Glutathionylation in Aortic Valve Sclerosis Patients with Overt Atherosclerosis"</p> <p> </p> <p><strong>Abstract</strong></p> <p>Aortic valve sclerosis (AVSc) is characterized by non-uniform thickening of the leaflets without hemodynamic changes. Endothelial dysfunction, also caused by dysregulation of glutathione homeostasis expressed as ratio between its reduced (GSH) and its oxidised form (GSSG), could represent one of the pathogenic triggers of AVSc. We prospectively enrolled 58 patients with overt atherosclerosis and requiring coronary artery bypass grafting (CABG). The incidence of AVSc in the studied population was 50%. The two groups (No-AVSc and AVSc) had similar clinical characteristics. Pre-operatively, AVSc group showed significantly lower GSH/GSSG ratio than No-AVSc group (<em>p = </em>0.02). Asymmetric dimethylarginine (ADMA) concentration was significantly higher in AVSc patients compared to No-AVSc patients (<em>p < </em>0.0001). Explanted sclerotic aortic valves presented a significantly increased protein glutathionylation (Pr-SSG) than No-AVSc ones (<em>p = </em>0.01). In vitro, inhibition of glutathione reductase caused β-actin glutathionylation, activation of histone 2AX, upregulation of α2 smooth muscle actin (<em>ACTA2</em>), downregulation of platelet and endothelial cell adhesion molecule 1 (<em>PECAM1</em>) and cadherin 5 (<em>CDH5</em>). In this study, we showed for the first time that the dysregulation of glutathione homeostasis is associated with AVSc. We found that Pr-SSG is increased in AVSc leaflets and it could lead to EndMT via DNA damage. Further studies are warranted to elucidate the causal role of Pr-SSG in aortic valve degeneration.</p>
Fig. 4 in Exogenous application of polyamines alleviates water stress-induced oxidative stress of Rosa damascena Miller var. trigintipetala Dieck
Fig. 4. Effects of foliar application of spermine (Spm) and spermidine (Spd) on endogenous polyamines (A: putrescine, B: spermine and C: spermidine) contents of Rosa damascena Miller var. trigintipetala Dieck leaves grown under water stress (50% FC) or non-stress (100% FC) conditions. Columns had different letters are significantly differ from each other according to Duncan multiple range test at P = 0.05 (n = 8).
Fig. 11 in Verniciflavanol A, a profisetinidin-type-4-arylflavan-3-ol from toxicodendron vernicifluum protects SH-SY5Y cells against H2O2-Induced oxidative stress
Fig. 11. Effects of verniciflavanol A (9) on IL-6/Src-STAT3 pathway. (A) The protein levels of IL-6/Src-Stat3 pathway in SH-SY5Y cells are analyzed by Western Blot. (B) Grey intensity analysis of IL-6, p-Src, p-STAT3. Data are presented as the mean ±SD of three independent experiments. *p <0.05 and ***p <0.001 ompared with indicated control. &p <0.05, &&p <0.01, and &&&p <0.001 compared with the H O -treated group.
Fig. 2 in Melatonin mitigates UV-B stress via regulating oxidative stress response, cellular redox and alternative electron sinks in Arabidopsis thaliana
Fig. 2. Activities of different SOD isoenzymes (90 and 180 min) and expressions of genes encoding different SODs (90 min) of UV-B treated A. thaliana plants with or without 10 μM melatonin supplement. Experiments were repeated two times, and each data point was the mean of three replicates (n = 6). Significant differences (P <0.05) were marked with different letters (a–d) in the charts.
Fig. 6 in Melatonin mitigates UV-B stress via regulating oxidative stress response, cellular redox and alternative electron sinks in Arabidopsis thaliana
Fig. 6. Expressions of glutathione biosynthesis (GSH1 and GSH2) and degradation (OXP1 and GGT1) related genes of UV-B treated (90 min) A. thaliana plants with or without 10 μM melatonin supplement. Experiments were repeated two times, and each data point was the mean of three replicates (n = 6). Significant differences (P <0.05) were marked with different letters (a–d) in the charts.
A New Exogenous Marker for Diagnosis of Oxidative Stress During Laproscopic Surgery
ClinicalTrials.gov study NCT01393587. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Soleus Muscle Push Ups on Oxidative Stress and Inflammatory Markers, Soleus Endurance, and Adipocytokines Between Type 2 Diabetic, Overweight/Obese and Normal Weight Individuals.
ClinicalTrials.gov study NCT06450847. IPD Sharing: YES. Countries: 0. Publications: 0.
Effect of Oral L-arginine 3.32 g a Day on Oxidative Stress Influencing Beta Cell Function and Insulin Resistance.
ClinicalTrials.gov study NCT06686069. IPD Sharing: NO. Countries: 0. Publications: 0.
Rapid Maxillary Expansion Related Oxidative Stress and Periodontal Results
ClinicalTrials.gov study NCT06937775. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Fat Emulsions on PNALD and Oxidative Stress in Premature Infants
ClinicalTrials.gov study NCT04277923. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Immunological and Oxidative Stress Response in Relation to Abdominal Cancer Surgery
ClinicalTrials.gov study NCT03473327. IPD Sharing: NO. Countries: 0. Publications: 0.
Effects of Periodontal Therapy on Markers of Acute Phase Response, Oxidative Stress
ClinicalTrials.gov study NCT03375372. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Urinary Marker for Oxidative Stress in Human Cisplatin- Induced Renal Injury
ClinicalTrials.gov study NCT00310739. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Multifunctional Substrate for Early Detection of Oxidative Stress Susceptibility and Application to Parkinson's Disease
ClinicalTrials.gov study NCT00271141. IPD Sharing: Not stated. Countries: 1. Publications: 0.
High Tea Consumption on Smoking Related Oxidative Stress
ClinicalTrials.gov study NCT02719860. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of Insulin Resistance Reducing Agents Pre and Post CABG on Post-operative Metabolic Status and Oxidative Stress
ClinicalTrials.gov study NCT02184507. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effect of Omega-3 Fatty Acids on Oxidative Stress and Dyslipidemia in Pediatric Patients Undergoing Hemodialysis
ClinicalTrials.gov study NCT02581449. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Insulin Like Growth Factor-1 Against Oxidative Stress in Vitiligo
ClinicalTrials.gov study NCT05812079. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease
ClinicalTrials.gov study NCT00431249. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.