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2,801 results for “diabetes mellitus”
COMPARATIVE EVALUATION OF COMPLICATIONS OF DIABETES MELLITUS - NEUROPATHY AND ANGIOPATHY.
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Impact of diabetes mellitus on results in the animal naming test in patients with and without liver cirrhosis
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Data from: Diabetes mellitus, glycemic traits, and cerebrovascular disease: A Mendelian randomization study
<p><span><span><span><span><span><span><span><span><span><span><span><b>Objective: </b>We employed Mendelian randomization (MR) to explore the effects of genetic predisposition to type 2 diabetes (T2D), hyperglycemia, insulin resistance, and β-cell dysfunction on risk of stroke subtypes and related cerebrovascular phenotypes.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><a name="_Hlk49339275"><b>Methods: </b></a>We selected instruments for genetic predisposition to T2D (74,124 cases, 824,006 controls), HbA1c levels (n=421,923), fasting glucose levels (n=133,010), insulin resistance (n=108,557), and β-cell dysfunction (n=16,378) based on published genome-wide association studies. Applying two-sample MR, we examined associations with ischemic stroke (60,341 cases, 454,450 controls), intracerebral hemorrhage (1,545 cases, 1,481 controls), and ischemic stroke subtypes (large artery, cardioembolic, small vessel stroke), as well as with related phenotypes (carotid atherosclerosis, imaging markers of cerebral white matter integrity, and brain atrophy). </span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Results: </b>Genetic predisposition to T2D and higher HbA1c levels were associated with higher risk of any ischemic stroke, large artery stroke, and small vessel stroke. Similar associations were also noted for carotid atherosclerotic plaque, fractional anisotropy, a white matter disease marker, and markers of brain atrophy. We further found associations of genetic predisposition to insulin resistance with large artery and small vessel stroke, whereas predisposition to β-cell dysfunction was associated with small vessel stroke, intracerebral hemorrhage, lower grey matter volume, and total brain volume.</span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Conclusions: </b>This study supports causal effects of T2D and hyperglycemia on large artery and small vessel stroke. </span></span></span></span></span></span></span></span></span></span></span><a name="_Hlk52240657">We show associations of genetically predicted insulin resistance and β-cell dysfunction with large artery and small vessel stroke that might have implications for anti-diabetic treatments targeting these mechanisms.</a></p> <p><span><span><span><span><span><span><span><span><span><span><span><b>Classification of Evidence:</b> This study provides Class II evidence that genetic predisposition to T2D and higher HbA1c levels are associated with a higher risk of large artery and small vessel ischemic stroke.</span></span></span></span></span></span></span></span></span></span></span></p>
Different plasma steroid profiles between patients with and without diabetes mellitus in non-functioning adrenal incidentalomas
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THE EFFECT OF GESTATIONAL DIABETES MELLITUS ON THE FETUS
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Physical activity interventions and nutrition-based interventions for children and adolescents with type 1 diabetes mellitus
<p>1. Baseline characteristics of participants</p> <p>2. Description of studies</p> <p>3. Data extraction_Excel</p>
Figure 1 from: Trifonova D, Gavrilova A, Dyakova G, Gavrilov G, Yotova M, Nikolov S (2021) Preliminary in vitro study of anti-oxidant activity and anti-diabetic potential of plant extracts from 4 herbal substances not traditionally used for treatment of diabetes mellitus. Pharmacia 68(4): 755-762. https://doi.org/10.3897/pharmacia.68.e72769
Figure 1 Relative enzyme activity of α-glucosidase by adding different concentration of (A) SKW and (B) acarbose IC50 values and relative enzyme activity were calculated for the samples which exhibited higher than 50% inhibition of α-glucosidase.
A Multicenter Study to Evaluate the Cholesterol Lowering Effects of Two Marketed Products in Patients With Type 2 Diabetes Mellitus and Hypercholesterolemia (MK-0653A-077)
ClinicalTrials.gov study NCT00110435. IPD Sharing: Not stated. Countries: 0. Publications: 2.
An Exploratory Study on the Effects of Repeat Doses of Albiglutide Compared to Exenatide on Gastric Myoelectrical Activity and Gastric Emptying in Type 2 Diabetes Mellitus Subjects
ClinicalTrials.gov study NCT02793154. IPD Sharing: NO. Countries: 1. Publications: 0.
Effect of Momordica Charantia Administration on Type 2 Diabetes Mellitus, Insulin Sensitivity and Insulin Secretion
ClinicalTrials.gov study NCT02397447. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Efficacy Study of Canagliflozin or Sitagliptin to Determine Glucose Variability in Mexican Participants With Type 2 Diabetes Mellitus Inadequately Controlled on Metformin
ClinicalTrials.gov study NCT03267576. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Social Support Intervention for Self-management of Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT04491253. IPD Sharing: NO. Countries: 1. Publications: 0.
Pharmacokinetics Study of Dipeptidyl Peptidase 4 Inhibitor to Control Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT01449747. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Lidocaine + Clonidine for Intraoral Anesthesia in Patients With Diabetes Mellitus Type 2
ClinicalTrials.gov study NCT02371759. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Sotagliflozin Versus Placebo in Chinese Patients With Type 2 Diabetes Mellitus Not Adequately Controlled by Diet and Exercise
ClinicalTrials.gov study NCT03760965. IPD Sharing: YES. Countries: 1. Publications: 0.
The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus
ClinicalTrials.gov study NCT02418884. IPD Sharing: Not stated. Countries: 0. Publications: 10.
A 6-Week Study Of PF-05175157 In Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT01792635. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Investigate Safety and Efficacy of iGlarLixi in Adult Patients With Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT06716424. IPD Sharing: YES. Countries: 1. Publications: 0.
Efficacy and Safety of Efpeglenatide Versus Dulaglutide in Patients With Type 2 Diabetes Mellitus Inadequately Controlled With Metformin
ClinicalTrials.gov study NCT03684642. IPD Sharing: NO. Countries: 4. Publications: 0.
Study to Evaluate the Efficacy of Androxal in Controlling Blood Glucose in Men With Type-2 Diabetes Mellitus
ClinicalTrials.gov study NCT01191320. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.