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1,258 results for “neuroblastoma”
Neuroblastoma Genome-Wide Association Study
Neuroblastoma is a malignancy of the developing sympathetic nervous system that most commonly affects young children and is often lethal. The etiology of this embryonal cancer is not fully understood. We therefore initiated a genome-wide association study (GWAS) in 2007 focused on neuroblastoma patients identified through the Children's Oncology Group (COG; 238 member institutions). Control patients for this study are children cared for at the Children's Hospital of Philadelphia (CHOP) without a diagnosis or family history of cancer. The study was initially designed to genotype 5,000 neuroblastoma cases and 10,000 controls and is powered to detect common susceptibility variants in Caucasian and African American patients. Whole genome genotyping was performed on multiple versions of Illumina SNP arrays. This version of the study represents the complete set of cases genotyped.
Elucidating Transcription Regulation by Epigenetics in Neuroblastoma
Whole-genome profiles of the epigenetic modification 5-hydroxymethylcytosine (5-hmC) are robust diagnostic biomarkers in adult patients with cancer. We investigated if 5-hmC profiles would serve as novel prognostic markers in neuroblastoma, a clinically heterogeneous pediatric cancer. Because this DNA modification facilitates active gene expression, we hypothesized that 5-hmC profiles would identify transcriptomic networks driving the clinical behavior of neuroblastoma.
TARGET: Neuroblastoma (NBL)
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Clonal evolution during metastatic spread in high-risk neuroblastoma
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Human iPSC modeling recapitulates in vivo sympathoadrenal development and reveals an aberrant developmental subpopulation in familial neuroblastoma [Bulk RNA-seq]
GEO Series GSE211660. Homo sapiens. 48 samples. Type: Expression profiling by high throughput sequencing.
Human embryonic stem cell-derived neural crest model for neuroblastoma
GEO Series GSE137975. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
CaSR modulator in neuroblastoma model [human]
GEO Series GSE73504. Homo sapiens. 15 samples. Type: Expression profiling by array.
PHOX2B promotes the occurrence and development of neuroblastoma by activating the MAPK signaling pathway
GEO Series GSE188622. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Genome methylation defines EZH2 inhibitor resistance in neuroblastoma [II]
GEO Series GSE143712. Homo sapiens. 12 samples. Type: Expression profiling by array.
Genome methylation defines EZH2 inhibitor resistance in neuroblastoma
GEO Series GSE143714. Homo sapiens. 36 samples. Type: Expression profiling by array.
Neuroblastoma copper chelation single-cell
<p>To access the data, please send an e-mail to antonietta.salerno@outlook.it specifying a valid reason for your request.</p>
Pre-clinical spheroid models identify BMX as a therapeutic target for metastatic MYCN non-amplified neuroblastoma
<p>The development of targeted therapies has provided new hope for an increasing number of cancer patients affected by previously incurable diseases. The clinical success of this approach, however, is limited by numerous challenges, including a better control of cell plasticity, particularly in refractory and metastatic patients. Here we addressed this question in Neuroblastoma (NB), an aggressive pediatric malignancy, which remains a clinical challenge for high-risk patients. NB originates from neural crest-derived progenitors through defective differentiation programs combined with oncogenic activity due to genetic and epigenetic alterations. In order to identify critical genes responsible for tumor aggressiveness we performed combined chromatin and transcriptome analyses on matched primary xenografts, spheroids and differentiated adherent cultures, which we derived from metastatic non-<em>MYCN</em> amplified (nMNA) NB patients. Our approach identified the kinase <em>BMX</em> among the most differentially regulated genes between patient-derived xenografts and spheroids versus adherent models. We further found that <em>BMX</em> expression is associated with high tumor stage and poor patient survival in multiple NB transcriptomic datasets and critical to maintain the self-renewal and tumorigenic potential of NB spheroids. Moreover, we uncovered a positive correlation between <em>BMX </em>expression and the mesenchymal tumor cell phenotype, which was previously associated with increased chemo-resistance. Finally, we show that BMX inhibitors can readily reverse this cellular state, increase the sensitivity of NB spheroids toward standard of care chemotherapy, and reduce tumor growth in preclinical NB models. Altogether, our study identifies BMX as a novel promising therapeutic target for high-risk patients with relapsed or refractory nMNA NB tumors.</p>
Surgical Planning in Pediatric Neuroblastoma (MICCAI 2023) - Training Dataset
<p>The training dataset for the <a href="https://sppin.grand-challenge.org/">SPPIN</a> challenge. Please do not share this dataset without permision.</p>
Combination Chemotherapy and Surgery With or Without Radiation Therapy in Treating Patients With Stage 2 or Stage 3 Neuroblastoma
ClinicalTrials.gov study NCT00416676. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant
ClinicalTrials.gov study NCT00417053. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Study of gene expression changes in TH-MYCN murine neuroblastomas in response to 24hr of panobinostat treatment
GEO Series GSE69869. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
CaSR modulator in neuroblastoma model
GEO Series GSE73509. Homo sapiens; Mus musculus. 31 samples. Type: Expression profiling by array.
ATR inhibition synergizes with alkylating PI polyamide targeting MYCN by suppressing DNA repair in MYCN-amplified neuroblastoma
GEO Series GSE285823. Homo sapiens. 16 samples. Type: Expression profiling by array.
Gene expression after treatment with Nutlin 3a (Nut) and Selinexor (Sel) in Neuroblastoma Cells
GEO Series GSE137366. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Neuroblastoma plasticity during metastatic progression stems from the dynamics of an early sympathetic transcriptomic trajectory
GEO Series GSE237881. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.