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1,276 results for “Stromal cells”
Single-Cell RNA-seq Reveals FGF12 as a Prognostic Biomarker in Low-Grade Endometrial Stromal Sarcoma
<p><strong><span>Abstract </span></strong></p> <p><strong><span>Background: </span></strong><span>Low-grade endometrial stromal sarcoma (LG-ESS) is a rare uterine malignancy characterized by its complex tumor microenvironment (TME) and significant recurrence rates, posing challenges in accurate prognosis and effective treatment. Identifying prognostic biomarkers is essential to improve patient stratification and guide therapeutic strategies.</span></p> <p><span> </span></p> <p><strong><span>Methods: </span></strong><span>Using single-cell transcriptome analysis combined with H&E and multiplex immunofluorescence staining, we identified a subpopulation of tumor cells in LG-ESS and further validated the association of this subpopulation and its characteristic genes with LG-ESS prognosis by molecular characterization and bulk transcriptome data.</span></p> <p><span> </span></p> <p><strong><span>Results: </span></strong><span>Our analysis reveals multiple cellular subpopulations within the tumor tissue, particularly a tumor cell subpopulation among them which is associated with poor prognosis. Originating from normal stromal fibroblasts, this subpopulation appears to play a crucial role in TME remodeling, smooth muscle cell behavior, and potentially in tumorigenesis and metastasis. At particular interest in this subpopulation is the highly expressed FGF12 gene, which is significantly associated with a shortened survival time of ESS, highlighting its potential as a prognostic biomarker.</span></p> <p><span> </span></p> <p><strong><span>Conclusion: </span></strong><span>Our study reveals the complexity of TME within the LG-ESS and highlights the role that tumor cell subpopulations play in disease progression and patient prognosis. The identification of FGF12 as prognostic biomarkers suggests new approach for the personalized treatment and prognosis monitoring of patients. </span></p>
Gene expression analysis of bone marrow stromal cells from multiple myeloma patients and controls
GEO Series GSE85837. Homo sapiens. 28 samples. Type: Expression profiling by array.
Mesenchymal Stromal Cell Senescence Induced by Dnmt3a-Mutant Haematopoietic Cells is a Targetable Mechanism Driving Clonal Haematopoiesis and Initiation of Leukemia
GEO Series GSE240686. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
GATA2 and progesterone receptor interaction in endometrial stromal cells undergoing decidualization [ChIP-Seq]
GEO Series GSE145673. Homo sapiens. 7 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Single cell RNAseq analysis of fetal perichondrium-derived bone marrow mesenchymal stromal cells
GEO Series GSE126967. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
T cell-mediated development of stromal fibroblasts with an immune-enhancing chemokine profile [single-cell RNA-seq]
GEO Series GSE228836. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Safety and preliminary efficacy of allogeneic bone marrow-derived multipotent mesenchymal stromal cells for systemic sclerosis: a single-centre, open-label, dose-escalation, proof-of-concept, phase 1/
GEO Series GSE176055. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
GEO Series GSE178745. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Small intestinal lymph node identity is defined by medullary stromal cells in humans
GEO Series GSE281776. Homo sapiens. 81 samples. Type: Expression profiling by high throughput sequencing.
Effects of hyperbaric oxygen on tissue-specific aging and senescence in mice and human stromal cells
GEO Series GSE296209. Mus musculus; Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Cultured human amniotic fluid-derived mesenchymal stromal cells [miRXplore data]
GEO Series GSE30065. Homo sapiens; Mus musculus; Rattus norvegicus; synthetic construct. 4 samples. Type: Non-coding RNA profiling by array.
Expression profiling in cellular miRNAs of human bone marrow stromal cells
GEO Series GSE78866. Homo sapiens. 6 samples. Type: Other.
RNA seq analysis of uterine stromal cells from ovariectomized (OVX) Atg7f/f;Amhr2cre mice
GEO Series GSE131304. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Comparative gene expression profile of human limbal stromal cells, bone marrow mesenchymal cells, adipose cells and foreskin fibroblasts
GEO Series GSE38947. Homo sapiens. 15 samples. Type: Expression profiling by array.
Therapeatic evaluation and single cell analysis of adipose stromal vascular fraction isolation from a commercial cell separation system
GEO Series GSE308930. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Observation of the Changes in Chemokine-related Gene Expression of Endometriotic Cyst Stromal Cells by Three-dimensional Collagen Gel Culture
GEO Series GSE136412. Homo sapiens. 16 samples. Type: Expression profiling by array.
Fibronectin-guided immune-stromal cell crosstalk promotes angiogenesis in pulp-dentin complex regeneration
GEO Series GSE299319. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Genome wide H3K27ac status of endometrial stromal cells stimulated by cAMP, and cAMP under C/EBPb-knockdown
GEO Series GSE148620. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RNA-seq data for studying the influence of fallopian tube stromal cells and/or estrogen treatment on fallopian tube epithilial cells
GEO Series GSE310469. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Endothelial stromal cells enhance lung-tumor cell migration through TNFα and SDF-1α secretion
GEO Series GSE42076. Homo sapiens. 24 samples. Type: Expression profiling by array.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.