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199
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ShareScore release 0.9.0
Dataset results
199 results for “Adaptive Systems”
Data from: Mating system and environmental variation drive patterns of adaptation in Boechera spatifolia (Brassicaceae)
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Data from: Dealing with the adaptive immune system during de novo evolution of genes from intergenic sequences
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Data from: Cardinalfishes (Apogonidae) show visual system adaptations typical of nocturnally and diurnally active fish
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A brief exposure to rightward prismatic adaptation changes resting-state network characteristics of the ventral attentional system
<p>A brief session of rightward prismatic adaptation (R-PA) has been shown to alleviate neglect symptoms in patients with right hemispheric damage, very likely by switching hemispheric dominance of the ventral attentional network (VAN) from the right to the left and by changing task-related activity within the dorsal attentional network (DAN). We have investigated this very rapid change in functional organisation with a network approach by comparing resting-state connectivity before and after a brief exposure i) to R-PA (14 normal subjects; experimental condition) or ii) to plain glasses (12 normal subjects; control condition). A whole brain analysis (comprising all 129 regions of interest) highlighted R-PA-induced changes within a bilateral, fronto-temporal network, which consisted of 13 nodes and 11 edges; all edges involved one of 4 frontal nodes, which were part of VAN. The analysis of network characteristics within VAN and DAN revealed a R-PA-induced decrease in connectivity strength between nodes and a decrease in local efficiency within VAN but not within DAN. These results indicate that the resting-state connectivity configuration of VAN is modulated by R-PA, possibly by decreasing its modularity.</p>
Data from: Mating system plasticity promotes persistence and adaptation of colonizing populations of hermaphroditic angiosperms
Persistence and adaptation in novel environments are limited by small population size, strong selection, and maladaptive gene flow. Mating system plasticity is common in angiosperms and may provide both demographic and genetic benefits that promote niche evolution, including reproductive assurance and isolation from maladaptive gene flow. Yet increased self-fertilization may also cause inbreeding depression, accumulation of deleterious mutations, and reduced adaptive potential. Here we use individual-based simulations to examine the consequences of mating system plasticity for persistence and adaptation in a novel environment that imposes selection on a quantitative trait. We examine the joint evolution of local adaptation, inbreeding depression, and genetic load. We find that a plastic shift to a mixed mating system generally promotes niche evolution by decreasing the risk of extinction, providing isolation from maladaptive gene flow, and temporarily increasing genetic variance in the trait under selection, whereas obligate self-fertilization reduces adaptive potential. These effects are most pronounced under conditions of mate limitation, strong selection, or maladaptive gene flow. Our results highlight the diverse demographic and genetic consequences of self-fertilization and support the potential role for plastic shifts in mating system to promote niche evolution in flowering plants.
MAgPIE model input data sets: Climate change-driven global land-use system adaptation under CMIP6-based crop model projections
<p>These MAgPIE input data sets include harmonized crop yield projections from several crop models (9 crop models and 5 climate models). Additionally, regional, validation, and calibration data sets are also reported.</p>
Experimental data: Adaptive Production Rescheduling System for Managing Unforeseen Disruptions
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Data from: Systems analysis of adaptive responses to MAP Kinase pathway blockade in BRAF mutant melanoma
Fifty percent of cutaneous melanomas are driven by activated BRAFV600E, but tumors treated with RAF inhibitors, even when they respond dramatically, rapidly adapt and develop resistance. Thus, there is a pressing need to identify the major mechanisms of intrinsic and adaptive resistance and develop drug combinations that target these resistance mechanisms. In a combinatorial drug screen on a panel of 12 treatment-naïve BRAFV600E mutant melanoma cell lines of varying levels of resistance to mitogen-activated protein kinase (MAPK) pathway inhibition, we identified the combination of PLX4720, a targeted inhibitor of mutated BRaf, and lapatinib, an inhibitor of the ErbB family of receptor tyrosine kinases, as synergistically cytotoxic in the subset of cell lines that displayed the most resistance to PLX4720. To identify potential mechanisms of resistance to PLX4720 treatment and synergy with lapatinib treatment, we performed a multi-platform functional genomics analysis to profile the genome as well as the transcriptional and proteomic responses of these cell lines to treatment with PLX4720. We found modest levels of resistance correlated with the zygosity of the BRAF V600E allele and receptor tyrosine kinase (RTK) mutational status. Layered over base-line resistance was substantial upregulation of many ErbB pathway genes in response to BRaf inhibition, thus generating the vulnerability to combination with lapatinib. The transcriptional responses of ErbB pathway genes are associated with a number of transcription factors, including ETS2 and its associated cofactors that represent a convergent regulatory mechanism conferring synergistic drug susceptibility in the context of diverse mutational landscapes.
Artifact for paper "Lifelong Dynamic Optimization for Self-Adaptive Systems: Fact or Fiction?" published at IEEE SANER 2022
<p>The zip file contains all the source code and data for the experiments.</p>
NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations)
ClinicalTrials.gov study NCT06269367. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Effectiveness Study of the Precision SCS Systems Adapted for High-Rate Spinal Cord Stimulation
ClinicalTrials.gov study NCT02093793. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Post-Market Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (CF-EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation
ClinicalTrials.gov study NCT01196923. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adapting Diabetes Treatment Expert Systems to Patient in Type 1 Diabetes
ClinicalTrials.gov study NCT04443153. IPD Sharing: YES. Countries: 1. Publications: 0.
Automatic Adaptive System Dialysis (AASD)
ClinicalTrials.gov study NCT01241994. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Spanish Translation and Cultural Adaptation of the Memory Support System
ClinicalTrials.gov study NCT03933085. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Study of the CardioFocus Endoscopic Ablation System - Adaptive Contact (EAS-AC) for the Treatment of Symptomatic Atrial Fibrillation
ClinicalTrials.gov study NCT00971204. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adaptive, Real-time, Intelligent System to Enhance Self-care of Chronic Disease
ClinicalTrials.gov study NCT03643692. IPD Sharing: NO. Countries: 1. Publications: 0.
Building Access to Food Through Systems and Solidarity (BASIS): A Subsidized and Culturally-adapted Produce Box Program for Immigrant Communities of Brooklyn, NY
ClinicalTrials.gov study NCT07076251. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Hosts are ahead in a marine host-parasite coevolutionary arms race: innate immune system adaptation in pipefish Syngnathus typhle against Vibrio phylotypes
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Data from: Comparative system identification of flower tracking performance in three hawkmoth species reveals adaptations for dim light vision
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ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.