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Dataset results
269 results for “Aldosterone”
Primary Aldosteronism LC-MS/MS-specific Cutoffs
ClinicalTrials.gov study NCT05959863. IPD Sharing: NO. Countries: 1. Publications: 6.
Study on the Incidence of Adrenal Insufficiency After Surgery in Primary Aldosteronism Patients Concurrent With or Without Autonomous Cortisol Secretion
ClinicalTrials.gov study NCT06955286. IPD Sharing: NO. Countries: 1. Publications: 11.
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism
ClinicalTrials.gov study NCT00155064. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Prevalence of Primary Aldosteronism in Hypertensive Patients Presenting With Atrial Flutter or Fibrillation
ClinicalTrials.gov study NCT01267747. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Aldosterone and dexamethasone activate African lungfish mineralocorticoid receptor: Increased activation after removal of the amino-terminal domain
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Diagnostic Accuracy of Adrenal Imaging for Subtype Diagnosis in Primary Aldosteronism: Systematic Review and Meta-Analysis
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Data from: Aldosterone reduction rate after saline infusion may be a novel clinical prediction of determining subtypes of primary aldosteronism
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The neuropeptide substance P regulates aldosterone secretion in human adrenals
<p>Excel file of data demonstrating in vitro that the neuropeptide Substance P regulates aldosterone secretion in the human adrenal.</p>
Data from: Tolerability and efficacy of long-term medical therapy in primary aldosteronism
<p>Introduction: Patients with primary aldosteronism (PA) have increased cardiovascular risk and studies have found that medical therapy fails to ameliorate this. This may be due to side effects and limited efficacy of medications at tolerable doses.</p> <p>Methods: We conducted a retrospective study on 201 patients with PA treated with medical therapy (spironolactone, eplerenone or amiloride) for PA from 2000-2020 at two tertiary centres. Patients were assessed for efficacy to achieve clinical and biochemical control, and for side effects.</p> <p>Results: 53.7% of patients achieved blood pressure <140/90mmHg, 44.6% achieved potassium ≥4.3mmol/L, 63.2% achieved renin >1ng/ml/hr, and only 24.6% achieved all three. Concordance of biochemical control using potassium and renin levels was 49%. 45.3% of patients experienced side effects, with 8.5% switching to another medication, 18.9% decreasing dose, and 10.0% stopping medications altogether. Risk factors for side effects were spironolactone use, dose ≥50mg, duration of treatment ≥1year, male gender and unilateral PA. Patients with unilateral PA, compared to bilateral PA, used higher median doses of spironolactone, 75mg vs 50mg, <i>P</i><0.001, but more had persistent hypokalemia, 20.5% vs 6.4%, <i>P</i>=0.007. 44 patients with unilateral PA underwent surgery after initial medical therapy, which further improved systolic and diastolic BP, from 142 to 134mmHg, <i>P</i><0.001, and from 85 to 79mmHg, <i>P</i><0.001, respectively.</p> <p>Conclusion: Dose-dependent side effects limit the efficacy of medical therapy in PA. Future prospective studies should assess the best monitoring strategy for biochemical control during long-term medical therapy. In patients with unilateral PA, surgery remains a better option compared to life-long medications.</p>
Effect of Azilsartan on Aldosterone in Postmenopausal Females
ClinicalTrials.gov study NCT01774591. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Postoperative Cardiovascular Index Change of Primary Aldosteronism
ClinicalTrials.gov study NCT00746070. IPD Sharing: Not stated. Countries: 0. Publications: 4.
Low Dose Versus Aggressive Inhibition of the Renin-Angiotensin-Aldosterone (RAS) to Treat Microalbuminuria
ClinicalTrials.gov study NCT00907374. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Is the Evolution of the Aldosterone-renin Ratio Pre- Versus Post-operative on Day 1 Following Unilateral Adrenalectomy for Primary Hyperaldosteronism Predictive of Blood Pressure Outcomes
ClinicalTrials.gov study NCT07110155. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Endogenous Renin-Angiotensin-Aldosterone System and Glucose Metabolism
ClinicalTrials.gov study NCT02034435. IPD Sharing: Not stated. Countries: 1. Publications: 0.
DP13 - A Phase II Study in Patients With Primary Aldosteronism
ClinicalTrials.gov study NCT04007406. IPD Sharing: NO. Countries: 1. Publications: 0.
Optimalization of Nephroprotection Using Agents Inhibiting Renin-Angiotensin-Aldosterone System
ClinicalTrials.gov study NCT00528385. IPD Sharing: Not stated. Countries: 0. Publications: 2.
Multi-omics Studies of Primary Aldosteronism
ClinicalTrials.gov study NCT07111351. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: Tolerability and efficacy of long-term medical therapy in primary aldosteronism
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Differential antagonistic effects of finerenone and spironolactone on the aldosterone transcriptome in human kidney cells.
GEO Series GSE151321. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of androgen on aldosterone and high salt induced aortic aneurysms in mice
GEO Series GSE255682. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
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