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117
datasets available to search
ShareScore release 0.9.0
Dataset results
117 results for “Cardiac muscle”
Time series of diabetes and exercise training induced expression changes in cardiac muscle of mice
GEO Series GSE4616. Mus musculus. 12 samples. Type: Expression profiling by array.
Extraocular, hindlimb, and cardiac muscles, comparison of dko and mdx mice (Porter lab)
GEO Series GSE1463. Mus musculus. 18 samples. Type: Expression profiling by array.
In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors [HS1001 differentiation protocol]
GEO Series GSE100722. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors [LN-521 or LN-521+LN-221]
GEO Series GSE101076. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Expression signature of cardiac muscle as a potential diagnostic or prognostic tool for dilated cardiomyopathy
GEO Series GSE9800. Homo sapiens. 30 samples. Type: Expression profiling by array.
In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors [H1 differentiation protocol]
GEO Series GSE101132. Homo sapiens. 44 samples. Type: Expression profiling by high throughput sequencing.
RNAseq analysis of quadriceps muscles from adult mice with constitutively active skeletal and cardiac muscle mTORC1 (through conditional knockout of Tsc1 under the Mck Cre) and their wild type litter
GEO Series GSE84312. Mus musculus. 28 samples. Type: Expression profiling by high throughput sequencing.
Cardiac and Soleus muscles following exposure of rats to heat acclimation and exercise training
GEO Series GSE7799. Rattus norvegicus. 14 samples. Type: Expression profiling by array.
Histone deacetylase inhibition replicates aspects of the adaptive response to exercise and improves muscle metabolism and cardiac function in obesity.
GEO Series GSE54642. Mus musculus. 20 samples. Type: Expression profiling by array.
Cardiac Muscle Ring Finger-1 (MuRF1) and Transcriptional Regulation of Ischemia-Reperfusion Injury In Vivo
GEO Series GSE108940. Mus musculus. 24 samples. Type: Expression profiling by array.
Cardiac muscle, comparisons of wild type and mdx mice, 8 week and 10.5 month (Porter lab)
GEO Series GSE1471. Mus musculus. 12 samples. Type: Expression profiling by array.
Bioengineering of a human innervated cardiac muscle model
GEO Series GSE232464. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Expression alternations in liraglutide treated rats cardiac muscle
GEO Series GSE102200. Rattus norvegicus; synthetic construct. 12 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Short-term Akt activation in cardiac muscle cells improves contractile dysfunction in failing hearts.
GEO Series GSE4728. Mus musculus. 18 samples. Type: Expression profiling by array.
NGS-based miRNome profile in cardiac muscle tissue of congenital heart disease patients
GEO Series GSE185565. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
In vivo generation of post-infarct human cardiac muscle by laminin-promoted cardiovascular progenitors
GEO Series GSE100725. Homo sapiens. 88 samples. Type: Expression profiling by high throughput sequencing.
Data set from Bosè F, Renna LV, Fossati B, Arpa G, Labate V, Milani V, Botta A, Micaglio E, Meola G, Cardani R. TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2. Front Neurol. 2019 Sep 27;10:992. doi: 10.3389/fneur.2019.00992. PMID: 31611837; PMCID: PMC6776629.
<p>Data set from Bosè F, Renna LV, Fossati B, Arpa G, Labate V, Milani V, Botta A, Micaglio E, Meola G, Cardani R. TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2. Front Neurol. 2019 Sep 27;10:992. doi: 10.3389/fneur.2019.00992. PMID: 31611837; PMCID: PMC6776629.</p> <p> </p> <p>This is the abstract:</p> <p> </p> <p>Cardiac involvement is one of the most important manifestations of the multisystemic phenotype of patients affected by myotonic dystrophy (DM) and represents the second cause of premature death. Molecular mechanisms responsible for DM cardiac defects are still unclear; however, missplicing of the cardiac isoform of troponin T (<em>TNNT2</em>) and of the cardiac sodium channel (<em>SCN5A</em>) genes might contribute to the reduced myocardial function and conduction abnormalities seen in DM patients. Since, in DM skeletal muscle, the <em>TNNT2</em> gene shows the same aberrant splicing pattern observed in cardiac muscle, the principal aim of this work was to verify if the <em>TNNT2</em> aberrant fetal isoform expression could be secondary to myopathic changes or could reflect the DM cardiac phenotype. Analysis of alternative splicing of <em>TNNT2</em> and of several genes involved in DM pathology has been performed on muscle biopsies from patients affected by DM type 1 (DM1) or type 2 (DM2) with or without cardiac involvement. Our analysis shows that missplicing of muscle-specific genes is higher in DM1 and DM2 than in regenerating control muscles, indicating that these missplicing could be effectively important in DM skeletal muscle pathology. When considering the <em>TNNT2</em> gene, missplicing appears to be more evident in DM1 than in DM2 muscles since, in DM2, the <em>TNNT2</em> fetal isoform appears to be less expressed than the adult isoform. This evidence does not seem to be related to less severe muscle histopathological alterations that appear to be similar in DM1 and DM2 muscles. These results seem to indicate that the more severe <em>TNNT2</em> missplicing observed in DM1 could not be related only to myopathic changes but could reflect the more severe general phenotype compared to DM2, including cardiac problems that appear to be more severe and frequent in DM1 than in DM2 patients. Moreover, <em>TNNT2</em> missplicing significantly correlates with the QRS cardiac parameter in DM1 but not in DM2 patients, indicating that this splicing event has good potential to function as a biomarker of DM1 severity and it should be considered in pharmacological clinical trials to monitor the possible effects of different therapeutic approaches on skeletal muscle tissues.</p> <p><strong>Keywords: </strong> alternative splicing; cardiac involvement; cardiac troponin T; myotonic dystrophies; skeletal muscle.</p>
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.