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236
datasets available to search
ShareScore release 0.9.0
Dataset results
236 results for “Chronic rhinosinusitis”
Doxycycline in Treating Patients With Chronic Rhinosinusitis With Nasal Polyps
ClinicalTrials.gov study NCT02569437. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
ClinicalTrials.gov study NCT02285283. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy of Macrolide and Glucocorticoid in the Treatment of Chronic Rhinosinusitis After Endoscopic Sinus Surgery
ClinicalTrials.gov study NCT02182492. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis
ClinicalTrials.gov study NCT01955980. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Etokimab in Adults With Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
ClinicalTrials.gov study NCT03614923. IPD Sharing: NO. Countries: 1. Publications: 0.
A Clinical Evaluation of the Sinexus Intranasal Splint Following Functional Endoscopic Sinus Surgery in Patients With Chronic Rhinosinusitis
ClinicalTrials.gov study NCT00840970. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Medical Therapy Versus Balloon Sinus Dilation for Patients With Chronic Rhinosinusitis
ClinicalTrials.gov study NCT01685229. IPD Sharing: YES. Countries: 1. Publications: 0.
Impact of Posterior Nasal Neurectomy With Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis With Nasal Polyposis:A Comparative Study
ClinicalTrials.gov study NCT04105361. IPD Sharing: Not stated. Countries: 0. Publications: 1.
MicroRNA expression in chronic rhinosinusitis
GEO Series GSE32300. human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Homo sapiens; Betapolyomavirus hominis; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Rattus norvegicus. 9 samples. Type: Non-coding RNA profiling by array.
A global analysis of tandem 3'UTRs in eosinophilic chronic rhinosinusitis with nasal polyps
GEO Series GSE39957. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
scRNA-seq of CD4+ T cells from mouse allergic airway inflammation model and human patients with eosinophilic chronic rhinosinusitis (ECRS)
GEO Series GSE249159. Homo sapiens; Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
S100A8 Enhances IL-1β Production from Nasal Epithelial Cells in Eosinophilic Chronic Rhinosinusitis
GEO Series GSE172305. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Sinus Mast Cell Density Suggests a Unique Phenotype in Toxin Exposure-Associated Chronic Rhinosinusitis
GEO Series GSE313186. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Myeloid-derived IL1B drives epithelial and stromal cell remodeling during chronic rhinosinusitis and nasal polyps [scRNA-seq]
GEO Series GSE276503. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
STAT6 Blockade Abrogates Aspergillus-Induced Eosinophilic Chronic Rhinosinusitis and Asthma, a Model of Unified Airway Disease
GEO Series GSE193519. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps reveals distinct lncRNA expression profiles
GEO Series GSE72713. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Data from: Airflow in the human nasal passage and sinuses of chronic rhinosinusitis subjects
Chronic Rhinosinusitis (CRS) is a persistent inflammatory disease of the paranasal sinuses that is characterized by clinical symptoms that include a blocked nasal airway, mucus discharge, facial pain, headaches and anosmia [1, 2]. Functional endoscopic sinus surgery (FESS) is performed on patients who fail to improve following medical therapies such as antibiotics and corticosteroids (both systemic and topical nasal sprays). In sinus surgery, the goals are to open the obstructed sinus openings (ostia), to improve sinus ventilation and to restore mucociliary clearance. After initial surgery, a number of patients may continue to have ongoing symptoms and recalcitrant disease for which a more extensive operation such as the Modified Endoscopic Lothrop procedure (MELP) is performed [3–5]. The MELP procedure differs from standard frontal sinus dissection because both the frontal beak that narrows the frontal ostia, and the adjacent upper part of the nasal septum and frontal intersinus septum are removed, creating a single large common drainage pathway for both frontal sinuses. Current understanding of the relationship between nasal geometry (pre- and post-operative) and sinus ventilation is poor; and despite surgical intervention, efficient topical distribution of therapeutic drugs remains a significant challenge. Simulating nasal airflow in this complex patient group will improve our understanding of how surgical strategies affect post-surgical sinus ventilation, as well as providing new understanding for how drug delivery treatments and devices [6–10] can be designed to target delivery to the sinuses. Nasal passage is connected to sinus air pockets through an opening called ostia. Airflow in the human nasal cavity has been extensively studied using fluid dynamic simulations. We refer the reader to [11] and references there on. A number of studies have simulated airflow in both nasal passage and the sinuses [10, 12–24]. Xiong et al [12] simulated nasal airflow at 21 L/min in a normal healthy subject and found very little flow between the nasal passage and the sinuses. At the frontal sinus ostium they observed a limited flow rate of 0.014mL/s during inspiration and 0.018 mL/s during expiration. Zhu et al. [20] evaluated post-surgical airways after uncinectomy and bilateral inferior turbinate reduction and noticed that the surgery that aimed to affect flow partitioning also increased sinus ventilation in only one respiratory phase. The effects of surgery on altering nasal airflow is a complex realm and are not completely understood. Also, these studies do not sufficiently describe airflow in the sinus. This study describes airflow in the nasal passage and sinuses using fluid dynamic simulations. Specifically, airflow in pre-operative and post-operative CRS subject is investigated. FESS in CRS patients is known to increase nasal airway patency, however although this leads to reduced nasal resistance, the role of surgery in altering exchange of air between the sinus and nasal passages is not clear. Transient airflow is simulated in a healthy normal subject, a pre-operative subject with CRS, the same subject post-operatively after a standard FESS procedure, and a post-operative subject after a Lothrop procedure. Particular focus is given to describing airflow at the openings to the frontal and maxillary sinuses.
Effect of Electromagnetic Therapy on Patients With Chronic Rhinosinusitis.
ClinicalTrials.gov study NCT05865613. IPD Sharing: NO. Countries: 1. Publications: 0.
Olfaction and Inflammation in Chronic Rhinosinusitis With Nasal Polyps
ClinicalTrials.gov study NCT04104594. IPD Sharing: NO. Countries: 1. Publications: 0.
Ivacaftor for Acquired CFTR Dysfunction in Chronic Rhinosinusitis (EDSPD Protocol)
ClinicalTrials.gov study NCT02997020. IPD Sharing: NO. Countries: 1. Publications: 0.
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