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2,868 results for “ILS”
Gli animali marini e il rapporto con la diversità - Lezioni e lezioncine da (ri)ascoltare
<p>Lezioncina dal seminario "Animali marini" - come si possono studiare gli animali marini che troviamo in opere letterarie e altri artefatti?</p>
Egnazia, Fasano (BR). Il complesso residenziale di età messapica, ricostruzione virtuale e backend scientifico
<p>La ricostruzione virtuale (Altair4 Multimedia in collaborazione con il team dell'Università di Bari guidato da Gianluca Mastrocinque), di questo complesso residenziale indigeno, il primo documentato ad Egnazia con scavo stratigrafico, ha proceduto di pari passo con la prima pubblicazione scientifica, in un proficuo condizionamento reciproco per i diversi obiettivi.<br> Sono stati individuati 5 punti di vista corrispondenti a quelli della domus ad atrio romana, per visualizzare efficacemente la trasformazione, con relativo back-end scientifico: vista dall’esterno per il rapporto con il tessuto urbano della più antica città (V01), cortile centrale (V02), recinto sacro in corrispondenza del sacrario della casa romana (V04), due viste del grande vano artigianale (V05, V06), di cui la prima in corrispondenza della fornace in situ.<br> Particolarmente accurato è stato il lavoro per la resa di questo vano: in quanto ambiente unico, è stato necessario inserire due pilastri per ridurre la luce della trave principale, sono state studiate aperture per l’areazione e il deflusso dei fumi di combustione, di cui è stata realizzata una simulazione dinamica per verificare i parametri dimensionali. Sono stati ricostruiti gli arredi per l’essiccatura e lo stoccaggio delle ceramiche, tra cui la trozzella, produzione tipica della Messapia conservata nel Museo, di cui è stato creato un modello fotogrammetrico. Il modello tridimensionale è stato realizzato con Autodesk 3DSTUDIO MAX, e renderizzato con V-RAY. Sono incluse nel dataset le immagini panoramiche a 360° dello stato attuale dei 5 punti prescelti realizzate con camera INSTA360 PRO2 per le riprese a terra e i rendering a 360° realizzati dai medesimi punti di vista.</p>
Egnazia, Fasano (BR). La piazza messapica e il mercato in erà romana, ricostruzione virtuale e backend scientifico.
<p>La ricostruzione della piazza in età messapica è stata realizzata da Altair4 Multimedia sulla base degli elementi planimetrici (piante di fase) che individuano la superficie dell’area, dei resti frammentari in situ dei bordi lastricati, che sono stati estesi a tutto il perimetro per similitudine e dei dati di scavo sistematizzati dal gruppo dell’Università di Bari guidato da Gianluca Mastrocinque. Per l’età romana Altair4 Multimedia si è basata sul modello ricostruttivo realizzato nel 2015 da Massimo Caggese per Altair srl, sul quale sono state operate alcune modifiche e integrazioni per aggiornarlo allo stato attuale delle conoscenze e delle condizioni di utilizzo, con l’inserimento dei banchi di vendita e delle relative merci e suppellettili sulla base dei ritrovamenti, secondo le indicazioni fornite dal team della Università di Bari. Per il periodo messapico è presente un solo punto di vista, al centro della piazza (V02), per l’età romana sono stati individuati 6 punti di vista privilegiati, ciascuno pertinente a un particolare aspetto della piazza del mercato e della attività che vi si svolgevano. Sono incluse nel dataset le immagini panoramiche a 360° dello stato attuale realizzate con camera INSTA360 PRO2 per le riprese a terra, e i rendering a 360° realizzati dai medesimi punti di vista realizzati con VRAY su Autodesk 3DS MAX. A ciascuno dei 6 punti di vista panoramici sono associate le immagini di backend con le informazioni relative alle fonti e ai processi interpretativi che hanno supportato l'ipotesi ricostruttiva.</p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Combined in vitro and cell-based selection display method producing specific binders against IL-9 receptor in high yields
<p>The FEBS Journal FJ-22-0728</p> <p>Combined in vitro and cell-based selection display method producing specific binders against IL-9 receptor in high yields</p> <p>Maroš Huličiak, Lada Biedermanová, Daniel Berdár, Štěpán Herynek, Lucie Kolářová,<br> Jakub Tomala, Pavel Mikulecký, and Bohdan Schneider</p> <p><em>Institute of Biotechnology of the Czech Academy of Sciences,<br> Průmyslová 595, 252 50 Vestec, Czech Republic</em></p> <p>Correspondence: Bohdan Schneider, Institute of Biotechnology of the Czech Academy of Sciences,<br> BIOCEV, CZ-252 50 Vestec, Czech Republic,<br> Tel: +420 728 303 566, e-mail: bohdan.schneider@ibt.cas.cz</p> <p>Abstract</p> <p>We combined cell-free ribosome display and cell-based yeast display selection to build specific protein binders to the extracellular domain of the human interleukin 9 receptor alpha (IL-9Rα). The target, IL-9Rα, is the receptor involved in the signaling pathway of IL-9, a pro-inflammatory cytokine medically important for its involvement in respiratory diseases. The successive use of modified protocols of ribosome and yeast displays allowed us to combine their strengths - the virtually infinite selection power of ribosome display and the production of (mostly) properly folded and soluble proteins in yeast display. The described experimental protocol is optimized to produce binders highly specific to the target, including selectivity to common proteins such as BSA, and proteins potentially competing for the binder such as receptors of other cytokines. The binders were trained from DNA libraries of two protein scaffolds called 57aBi and 57bBi developed in our laboratory. We show that the described unconventional combination of ribosome and yeast displays is effective in developing selective small protein binders to the medically relevant molecular target.</p>
Ultimo appuntamento con il bando 2023 del Premio Nazionale di Filosofia
<p>Presentazione, assieme ai giurati, dell'ultimo gruppo di sezioni del bando 2023 del Premio Nazionale di Filosofia: romanzo filosofico, riflessione filosofica, premio speciale di filosofia, evento filosofico, confilosofare a scuola, pratiche filosofiche.</p> <p>Esempio di romanzo filosofico: "La torre del diavolo" di Fabio Fineschi</p>
Development of a Predictive Model for In-Hospital Mortality in COVID-19 Patients Using CAR, IL-6, IL-6/LY, and NLR: A Single-Center Study in Indonesia
<p>Figure 1. ROC Curve of CAR, IL-6, IL-6/LY, and NLR</p> <p> </p> <p>Figure 2. Kaplan Meier curve of (a) CAR (b) IL-6 (c) IL-6/LY (d) NLR blue line represents group above cut off and green one represents group below cut-off</p> <p> </p>
Datasets for the article "Regulation of IL-24/IL-20R2 complex formation using photocaged tyrosines and UV light"
<p>The datasets include:</p> <p>- Circular dichroism (CD) spectra (Figure 3B).</p> <p>- Nano differential scanning fluorimetry (DSF) melting curves (Figure 3C).</p> <p>- Size-exclusion chromatography (SEC) elution profiles (Figure 3D).</p> <p>- Deconvoluted mass spectra (MS) (Figure 4).</p> <p>- Microscale thermophoresis (MST) binding curves (Figure 5A).</p> <p>- Yeast surface display (YSD) binding curves (Figure 5C)</p> <p>- UV/Visible spectra (Figure S6)</p> <p>- Dose-response curves derived from Western blots (WB) (Figure S12C).</p> <p>For more information, please read:</p> <p>Pham, P.N.; Zahradnik, J.; Kolarova, L.; Schneider, B.; Fuertes, G. Regulation Of IL-24/IL-20R2 Complex Formation Using Photocaged Tyrosines and UV Light. <em>Front. Mol. Biosci.</em> 2023, 10.</p> <p>doi: <a href="http://doi.org/10.3389/fmolb.2023.1214235">https://doi.org/10.3389/fmolb.2023.1214235</a></p>
Inflammation, Proteolysis and IL-1 Beta Receptor Inhibition in Chronic Hemodialysis Patients
ClinicalTrials.gov study NCT00420290. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Trial to Evaluate Reduction in Inflammation in Patients With Advanced Chronic Renal Disease Utilizing Antibody Mediated IL-6 Inhibition
ClinicalTrials.gov study NCT03926117. IPD Sharing: YES. Countries: 1. Publications: 4.
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation
ClinicalTrials.gov study NCT05147155. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Avelumab (Bavencio) With IL-15 in Subjects With Clear-Cell Renal Carcinoma
ClinicalTrials.gov study NCT04150562. IPD Sharing: YES. Countries: 1. Publications: 1.
A Phase Ib Study to Evaluate the Safety, Tolerability, and Pharmacokinetics (PK) of Avelumab in Combination With M9241(NHS-IL12) (JAVELIN IL-12)
ClinicalTrials.gov study NCT02994953. IPD Sharing: NO. Countries: 7. Publications: 1.
DC Vaccine Combined With IL-2 and IFNα-2a in Treating Patients With mRCC
ClinicalTrials.gov study NCT00085436. IPD Sharing: Not stated. Countries: 1. Publications: 1.
IL-6 in Exercise-Induced Anorexia
ClinicalTrials.gov study NCT03295968. IPD Sharing: NO. Countries: 1. Publications: 6.
Study of IL-22 IgG2-Fc (F-652) for Subjects With Grade II-IV Lower GI aGVHD
ClinicalTrials.gov study NCT02406651. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect Of Ophiochepalus Striatus Extract On Serum IGF-1 And IL-6 Levels In Elderly Patients With Sarcopenia
ClinicalTrials.gov study NCT05869383. IPD Sharing: NO. Countries: 1. Publications: 1.
Phase I Study of Recombinant Human IL-15 (rhIL-15) and Mogamulizumab for People With Refractory or Relapsed Adult T-Cell Leukemia and Mycosis Fungoides/Sezary Syndrome
ClinicalTrials.gov study NCT04185220. IPD Sharing: NO. Countries: 1. Publications: 2.
Bevacizumab, Autologous Tumor/DC Vaccine, IL-2 and IFNα-2b in Metastatic Renal Cell Carcinoma (RCC) Patients
ClinicalTrials.gov study NCT00913913. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney Cancer
ClinicalTrials.gov study NCT00328861. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.