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319
datasets available to search
ShareScore release 0.9.0
Dataset results
319 results for “Intestinal microbiota”
Therapeutic Potential of Lianli Decoction in Ulcerative Colitis: Role of Intestinal Microbiota and Immune Regulation
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Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
The intestinal microbiota influences the development and function of myeloid lineages such as neutrophils, but the underlying molecular mechanisms are unresolved. Using gnotobiotic zebrafish, we identified the immune effector Serum amyloid A (Saa) as one of the most highly induced transcripts in digestive tissues following microbiota colonization. Saa is a conserved secreted protein produced in the intestine and liver with described effects on neutrophils in vitro, however its in vivo functions remain poorly defined. We engineered saa mutant zebrafish to test requirements for Saa on innate immunity in vivo. Zebrafish mutant for saa displayed impaired neutrophil responses to wounding but augmented clearance of pathogenic bacteria. At baseline, saa mutants exhibited moderate neutrophilia and altered neutrophil tissue distribution. Molecular and functional analyses of isolated neutrophils revealed that Saa suppresses expression of pro-inflammatory markers and bactericidal activity. Saa's effects on neutrophils depend on microbiota colonization, suggesting this protein mediates the microbiota's effects on host innate immunity. To test tissue-specific roles of Saa on neutrophil function, we over-expressed saa in the intestine or liver and found that sufficient to partially complement neutrophil phenotypes observed in saa mutants. These results indicate Saa produced by the intestine in response to microbiota serves as a systemic signal to neutrophils to restrict aberrant activation, decreasing inflammatory tone and bacterial killing potential while simultaneously enhancing their ability to migrate to wounds.
Effect of Prebiotics on Intestinal Gas Production, Microbiota and Digestive Symptoms
ClinicalTrials.gov study NCT02618239. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Effect of Diet on Intestinal Microbiota and Obesity Markers in Adults
ClinicalTrials.gov study NCT01449383. IPD Sharing: Not stated. Countries: 0. Publications: 1.
The Efficacy of Beneficial Intestinal Microbiota in the Treatment of Migraine and Its Mechanism: Basic and Clinical Studies
ClinicalTrials.gov study NCT07092241. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy of Lyophilized Fecal Microbiota Transplantation Via Capsules for Intestinal Multidrug-resistant Bacteria Decolonization
ClinicalTrials.gov study NCT07106580. IPD Sharing: YES. Countries: 1. Publications: 0.
Effects of Fructan Prebiotics on the Intestinal Microbiota
ClinicalTrials.gov study NCT01277445. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of the Variation of the Intestinal Microbiota and the Integrity of the Intestinal Barrier in Patients With M.D.R. Germ-induced Pneumonia Undergoing Enteral Nutrition
ClinicalTrials.gov study NCT06485791. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Data from: Intestinal Serum Amyloid A suppresses systemic neutrophil activation and bactericidal activity in response to microbiota colonization
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Data from: Impact of helminth infections and nutritional constraints on the small intestine microbiota
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The intestinal microbiota modulates the transcriptional landscapes of iNKT cells
GEO Series GSE242752. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
The response of intestinal microbiota and immunity to increasing dietary iron in piglets
GEO Series GSE158245. Sus scrofa. 10 samples. Type: Expression profiling by high throughput sequencing.
Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice [RNA-Seq]
GEO Series GSE47735. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Microbiota-derived pentanoate promotes differentiation of regulatory T cells via enhancing iron uptake in the intestine.
GEO Series GSE195607. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
A Pathobiont of the Microbiota Balances Host Colonization and Intestinal Inflammation
GEO Series GSE20434. Mus musculus. 2 samples. Type: Expression profiling by array.
The intestinal microbiota programs DNA methylation to control tissue homeostasis and inflammation [RNA-seq]
GEO Series GSE136840. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Microbiota-derived pentanoate promotes differentiation of regulatory T cells via enhancing iron uptake in the intestine [scRNAseq_Treg]
GEO Series GSE195604. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
The intestinal microbiota programs DNA methylation to control tissue homeostasis and inflammation
GEO Series GSE137037. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Kruppel-like factor 2+ CD4 T cells avert microbiota induced intestinal inflammation [RNA-seq]
GEO Series GSE236148. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
GEO Series GSE100339. mouse gut metagenome; Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing; Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.