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114
datasets available to search
ShareScore release 0.9.0
Dataset results
114 results for “PD-L1 expression;”
SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion.
GEO Series GSE245450. Homo sapiens; Mus musculus. 50 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Gene Expression profile for the characterization of PD-L1 blockade in melanoma model
GEO Series GSE172320. Mus musculus. 90 samples. Type: Expression profiling by array.
ID3 Enhances PD-L1 Expression by Restructuring MYC and Promotes Colorectal Cancer Immune Evasion [RNA-seq]
GEO Series GSE275454. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Spatially resolved whole-transcriptomic and proteomic profiling of lung cancer and immune-microenvironment according to PD-L1 expression
GEO Series GSE265899. Homo sapiens. 95 samples. Type: Expression profiling by high throughput sequencing.
Fusobacterium nucleatum Induces PD-L1 Expression by Tumor-Associated Macrophages and Inhibits Anti-Tumor Immunity in Colorectal Cancer.
GEO Series GSE211257. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ID3 Enhances PD-L1 Expression by Restructuring MYC and Promotes Colorectal Cancer Immune Evasion [ChIP-seq]
GEO Series GSE275455. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Fusobacterium nucleatum Induces PD-L1 Expression by Tumor-Associated Macrophages and Inhibits Anti-Tumor Immunity in Colorectal Cancer.
GEO Series GSE172334. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Independent expression of circulating and tissue levels of PD-L1: correlation of clusters with tumor metabolism and outcome in patients with non-small cell lung cancer."
<p>PURPOSE:</p> <p>To evaluate the clinical-pathological and prognostic significance of the circulating PD-L1 level in patients with surgically treated NSCLC, by combining data for PD-L1 expression with other immune-related markers and tumor metabolism.</p> <p>METHODS:</p> <p>Overall, 40 patients with resected NSCLC (stage Ia-IIIa) who had preoperative blood storage and underwent staging PET/CT were enrolled for the study. In all cases, we determined plasma levels of PD-L1 (pg/ml), immune-reactive areas (IRA %) covered by CD3, CD68, CD20, CD8, PD-1, and PD-L1 in the tumor specimen, and metabolic parameters on PET, i.e., SUV<sub>max</sub>, SUV<sub>peak</sub>, metabolic tumor volume (MTV), and total lesion glycolysis (TLG). Variables were statistically analyzed to establish their association with disease-free survival (DFS).</p> <p>RESULTS:</p> <p>The circulating levels of PD-L1 in the bloodstream could be determined in 38/40 (95%) samples. The mean and median expression levels were 34.86 pg/ml and 24.83 pg/ml, respectively. We did not find any statistically significant correlation between circulating PD-L1 and tissue expression of PD-L1/PD-1. Some mild degree of positive correlation was determined between tissue PD-L1 and SUV<sub>max</sub> (ρ =&thinsp;0.390; p =&thinsp;0.0148). Hierarchical clustering combining circulating, tissue, and metabolic parameters identified clusters with high metabolic tumor burden or high expression of plasma PD-L1 levels (Z score ≥ 2) as having a poor DFS (p =&thinsp;0.033). The multivariate analysis detected stage and metabolism (i.e., SUV<sub>max</sub> and SUV<sub>peak</sub>) as independent prognostic factors for DFS.</p> <p>CONCLUSION:</p> <p>Plasma levels of PD-L1 are independent of the expression of PD-1/PD-L1 in NSCLC tumor tissue and, when combined with other clinical-pathological parameters, allow for the identification of clusters with different outcomes.</p>
Anti CD20 increases PD-L1 protein expression in a cell line of primary mediastinal B cell lymphoma through immunogenetic and micro RNA signaling
GEO Series GSE206130. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
SMARCD1 is a dual regulator of PD-L1 expression and cell proliferation facilitating tumor evasion
GEO Series GSE275535. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Objective to explore the mechanism of STAT3 regulating PD-L1 expression at transcriptional level after LIFR overexpression in pancreatic cancer cells.
GEO Series GSE176309. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic Blocking of VEGF Binding to Neuropilin-2 Diminishes PD-L1 Expression to Activate Anti-Tumor Immunity in Prostate Cancer
GEO Series GSE223811. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Quietly hiding: PD-L1 checkpoint expression in melanocyte stem cell quiescence and aging
GEO Series GSE261101. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression profile for the characterization of PD-L1 blockade in melanoma model
GEO Series GSE172239. Mus musculus. 90 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.