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Dataset results
118 results for “Recurrence Analysis”
Integrated multiomic analysis reveals comprehensive tumor heterogeneity in primary and recurrent hepatocellular carcinomas
GEO Series GSE164359. Homo sapiens. 47 samples. Type: Expression profiling by high throughput sequencing.
Bioinformatics analysis of differentially expressed genes and pathways in the development of Juvenile-Onset Recurrent Respiratory Papillomatosis
GEO Series GSE223304. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Integrated analysis of ovarian juvenile granulosa cell tumors reveals distinct epigenetic signatures and recurrent TERT rearrangements
GEO Series GSE192967. Homo sapiens. 32 samples. Type: Methylation profiling by array.
Comprehensive Analysis of DNA Methylation Patterns in Recurrent Miscarriage: Imprinted Genes and Their Regulation Across Sperm and Fetal-Maternal Tissues
GEO Series GSE287809. Homo sapiens. 12 samples. Type: Methylation profiling by genome tiling array.
SNP microarry analysis of primary and first recurrent pediatric ependymoma
GEO Series GSE50876. Homo sapiens. 29 samples. Type: Genome variation profiling by SNP array.
Expression profile of micro-RNAs and functional annotation analysis of their targets in human chorionic villi from early recurrent miscarriage
GEO Series GSE73025. Human alphaherpesvirus 2; Lymphocryptovirus; JC polyomavirus; Betapolyomavirus hominis; Human alphaherpesvirus 1; Cytomegalovirus; Betapolyomavirus macacae; Homo sapiens; Rhadinovirus; Merkel cell polyomavirus; Human immunodeficiency virus 1. 10 samples. Type: Non-coding RNA profiling by array.
Dataset related to article "Recurrence pattern of stereotactic body radiotherapy in oligometastatic prostate cancer: a multi-institutional analysis."
<p>PURPOSE:</p> <p>For patients with oligometastatic/oligorecurrent/oligoprogressive lymph node metastases from PCa, metastases-directed therapy is an emerging strategy. The aim of this retrospective study was to evaluate the oncological outcome and pattern of recurrence in patients treated with stereotactic body radiation therapy (SBRT) to lymph node metastases.</p> <p>METHODS:</p> <p>In this multi-institutional analysis, patients with a maximum of five lymph node metastases from PCa treated with SBRT were included. Primary endpoints of the analysis were local control (LC), out-of-field nodal progression-free survival (NPFS), overall progression-free survival (PFS), and overall survival (OS).</p> <p>RESULTS:</p> <p>109 patients and 155 lymph node metastases were evaluated. Patients' median age was 70.8 years (range 51-84) and median PSA before SBRT was 1.88 ng/ml (range 0.3-45.5 ng/ml). The dose delivered to the target ranged from 25 to 48 Gy in 4-7 fractions; median BED<sub>1.5</sub> <sub>Gy</sub> was 198 Gy (range 108.3-432 Gy). With a median follow-up of 16 months, LC rates at 1 and 3 years were 93% and 86%, respectively. In-field progression of disease was observed in 11 (7%) lesions. One- and 3‑year NPFS was 59% and 29%, and median NPFS was 15 months. Rates of OS at 1 and 3 years were 100% and 95%. The median time to administration of a systemic treatment after SBRT was 7.8 months (1.7-54.8).</p> <p>CONCLUSION:</p> <p>SBRT is an effective and well-tolerated treatment option in the management of lymph node metastases from PCa. Prospective trials are necessary to better select patients who benefit most from this ablative focal treatment and better define the recurrence patterns.</p>
Dataset related to article "Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"
<p>This record contains raw data related to article “Stereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity"</p> <p><strong>Introduction: </strong>Biliary tract cancers (BTC) are rare malignancies arising from biliary system. Systemic therapy is the cornerstone for stage IV disease, with poor overall survival (OS). Evidence is lacking about safety and efficacy of local ablative treatments, such as surgery and stereotactic body radiotherapy (SBRT) in the context of metastatic BTC (mBTC).</p> <p><strong>Materials and methods: </strong>We retrospectively analyzed clinical outcomes for a cohort of mBTC patients treated with SBRT for oligometastatic disease. Inclusion criteria were 1-5 distant metastases; SBRT with a dose/fraction of a least 5 Gy to a biological effective dose (BED) of at least 40 Gy considering an α/β of 10 Gy. Analyzed outcomes included local control (LC), distant progression-free survival (DPFS), PFS, and OS.</p> <p><strong>Results: </strong>51 patients meeting the inclusion criteria. Primary tumor sites were intrahepatic cholangiocarcinoma (35%), extrahepatic cholangiocarcinoma (31%), ampullary adenocarcinoma (20%), gallbladder adenocarcinoma (14%). 21 patients were treated on liver lesions, 17 on nodal metastasis, 5 patients on lung lesions, 4 patients on recurrence along the extrahepatic bile duct. After a median follow-up of 14 months median OS was 13.7 months, 1- and 2-year OS were 58% and 41%, respectively. Node and lung as metastatic sites were associated with a longer OS (p < 0.001). Median LC was 26.8 months, and intrahepatic cholangiocarcinoma was associated with longer LC (p = 0.036). Median DPFS was 11 months, with 1- and 2-year DPFS of 48% and 27.8%, respectively. Ten patients reported grade 1-2 toxicity and 2 cases of acute G3 biliary obstruction.</p> <p><strong>Conclusions: </strong>Stereotactic body radiotherapy (SBRT) is feasible in the context of mBTC. OS and PFS results are promising, considering that our patients were heavily pre-treated with systemic therapy. Patients with nodal or lung relapse have better prognosis. Distant relapses remain the main pattern of failure, but treatment of all metastatic sites seems to improve DMFS.</p>
Single cell transcriptome analysis of decidua macrophages in normal and recurrent spontaneous abortion patients
GEO Series GSE169269. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Methylation analysis of samples from a phase II clinical trial of decitatbine in combination with carboplatin in patients with recurrent, platinum resistant epithelial ovarian cancer
GEO Series GSE31826. Homo sapiens. 56 samples. Type: Methylation profiling by array.
Single-cell genetic analysis of clonal dynamics in colorectal adenomas indicates CDX2 gains as a predictor of recurrence
GEO Series GSE110221. Homo sapiens. 54 samples. Type: Genome variation profiling by genome tiling array.
Genome-wide methylation analysis of cerebrospinal fluid circulating tumor DNA: a new biomarker for recurrent glioblastoma
GEO Series GSE205514. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Array-based genome-wide transcriptome analysis of the left atrial appendage for the difference between SR maintenance group and AF recurrence group
GEO Series GSE176166. Homo sapiens. 7 samples. Type: Expression profiling by array.
Genome-wide methylation analysis of cerebrospinal fluid circulating tumor DNA: a new biomarker for recurrent glioblastoma [MeDIP-Seq]
GEO Series GSE205513. Homo sapiens. 7 samples. Type: Methylation profiling by high throughput sequencing.
Transcriptome analysis of patients with recurrent aphthous stomatitis suggests novel therapeutic targets
GEO Series GSE37265. Homo sapiens. 33 samples. Type: Expression profiling by array.
Identified important EEG channels in visually impaired subjects using recurrent analysis
<p>This database contains calculated channel significance indicators based on the application of recurrent analysis to EEG data, following the example of the article Runnova A, Selskii A, Emelyanova E, Zhuravlev M, Popova M, Kiselev A, Shamionov R. Modification of Joint Recurrence Quantification Analysis ( JRQA) for assessing individual characteristics from short EEG time series. Chaos. 2021;31(9):093116. doi: 10.1063/5.0055550. For each EEG channel of each subject, the channel significance indicator was separately calculated for all stimulus presentations in the cognitive test. The following is a description of the EEG setup, subjects, and experimental design.</p><p>To compare the performance of the method for identifying important channels, the frequency corresponding to the maximum amplitude and the central frequency of the spectrum were calculated using Fourier spectrum analysis. The latter was calculated so that the integral value of the probability density to the left of it and to the right of it were the same. This approach makes it possible to distinguish between high and low frequencies in the spectrum and, if necessary, evaluate them separately.</p><p>The values of the channel significance indicators for each subject are located in the «SR» folder. Frequencies corresponding to maximum amplitude are in folders «MaxFrequency». Center frequencies for all channels of each subject in the folder «CentralFrequency».</p><p>Data were recorded at 250 Hz sampling rate using the conventional monopolar method of registration with two reference points and N = 21 electrodes, located according to the "10–20" scheme. The adhesive Ag/AgCl electrodes in prewired head caps were used to detect EEG signals. Two reference electrodes, A1 and A2, were located on mastoids, while the ground electrode N was placed above the forehead. The EEG signals were filtered by a band-pass filter with cutoff points at 1.5 Hz (HP) and 35 Hz (LP) and a 50 Hz notch filter.</p><p>Children of middle school age participated as study subjects. The biomedical data were processed honoring the confidentiality and anonymity of the study respondents. Experimental work was carried out in compliance with ethical standards and approved by the local committee on research ethics at Saratov State University (Saratov, RF). Prior to the study, written consent of the parents was obtained for conducting neuropsychological experimental work, the subsequent data processing and publication of the results. The parents were present during all experiments in accordance with the requirements of the Russian Federation legislation.</p><p>The following design of experimental work was employed. All experiments were conducted in the mornings, on a typical school day. One of the classrooms was darkened with blinds. Children sat in comfortable chairs, adjusted to their heights to attain a comfortable stable position, leaning back in the chair. Their feet were flat on the floor. The total experimental work time was approximately 25 minutes for each subject.</p><p>The experiment included three short stages: background state of quiet wakefulness with eyes closed (about 3 minutes), simple cognitive test for counting sound signals (about 20 minutes), and repeated background state of quiet wakefulness with eyes closed (about 2 minutes). During the cognitive test, groups of short sounds were given: one to four per group. During listening, the subject was instructed to determine whether he perceived an even or an odd number of sounds in a single stimulus group. Depending on his assessment, the subject pressed the left or right buttons of a special remote control. Between groups of sound signals there was a silent pause lasting 5 to 11 seconds. Each child was analyzing these sound stimuli for 3 minutes, followed by a rest break lasting about 2 minutes.</p><p>The experimental work involved 4 boys 10 years of age (123,2±5,1 months). All children belonged to the health group I the Order of the Ministry of the Russian Federation Healthcare of March 13, 2019, No. 124n. They had no infectious or other acute illnesses one month prior to the experiment. Additionally, all children had no identified chronic diseases.</p>
Identified important EEG channels using recurrent analysis in patients with chronic migraine
<p>This database contains calculated indicators of channel significance based on the application of recurrent analysis to EEG data using the example of the article Runnova A, Selskii A, Emelyanova E, Zhuravlev M, Popova M, Kiselev A, Shamionov R. Modification of Joint Recurrence Quantification Analysis ( JRQA) for assessing individual characteristics from short EEG time series. Chaos. 2021;31(9):093116. doi: 10.1063/5.0055550. For each EEG channel of each subject, the channel significance indicator was separately calculated for all presentations of stimuli in the cognitive test, which are located in the SR folder. The RR_Simple_Hard folder contains the results of calculating significant channels separately for simple presentations - 3 and 4 squares, and complex presentations - 7 and 8 squares. A description of the EEG setup, subjects, and experimental design is provided below.</p><p>Test subjects volunteered to participate in the experiment. The biomedical data were processed honoring the confidentiality and anonymity of the study respondents. All procedures in studies involving human participants were conducted in accordance with the principles of the Declaration of Helsinki and approved by the Research Ethics Committee at Saratov State Medical University. Written informed consent was given by all participants. The participants were diagnosed in compliance with the diagnostic criteria of the International Classification of Headache Disorders (ICHD-3, beta version). We used the migraine questionnaire to evaluate the data on migraine attacks and disease courses. The exclusion criteria were acute headache, other neurological disorders, and intake of medicines targeting the central nervous system (including medications for migraine prophylaxis) within the preceding 24 h, as well as a Beck Depression Inventory (BDI) score >12 points. The sample comprised 23 subjects.</p><p>The study group included patients with chronic and recurrent migraine. The subjects had no other serious health problems, or drug or alcohol addictions. Patients were 27–66 years of age.</p><p>During all experiments, the multichannel EEG data were recorded using the EEG recorder Encephalan-EEGR-19/26 (Medicom MTD, Taganrog, Russian Federation). The data were recorded at a sampling rate of 500 Hz using the conventional monopolar recording technique with two reference electrodes and multiple recording electrodes (n = 31). EEG signals were obtained using special headcaps with prewired Ag/AgCl adhesive electrodes. Two reference electrodes, A1 and A2, were located on the mastoid processes, and the ground electrode (N) was placed above the forehead. EEG signals were filtered using a bandpass filter with cutoff frequencies of 0.5 Hz (high pass filter) and 30 Hz (low pass filter), and a notch filter of 50 Hz. The experiments were carried out in the early afternoon hours at a specially equipped laboratory. During monitoring, the subjects were in a comfortable reclining position in a neurophysiological chair with support for the neck and the back of the head in order to avoid the occurrence of artifacts associated with muscle tension in these areas. The neuropsychological experiment allowed for distinguishing cognitive ERPs. At the beginning and end of the experiment, passive wakefulness was recorded for 10 min each time. In between, the active part of the experiment was recorded for ~40 min. During the active part, short presentations of visual stimuli were delivered in a pseudorandom sequence. For all subjects, the order of stimulus presentation, duration of stimulus presentation, and duration of pauses between stimuli were identical. Each subject observed 350 stimuli. The stimulus was presented for 0.4–0.8 s. After its presentation, during a pause until the next stimulus, the subject saw solely a gray screen. Each visual stimulus per se was an image with a different number of squares (3–8). The task of the subject was to estimate an even or odd number of squares and make a choice by pressing one of two buttons on the remote control.</p>
Genome-wide methylation analysis of cerebrospinal fluid circulating tumor DNA: a new biomarker for recurrent glioblastoma [mRNA-Seq]
GEO Series GSE205512. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.