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3,134 results for βbone marrowβ
Data for: Osteocytes regulate senescence of bone and bone marrow
<p><span>The skeletal system contains a series of sophisticated cellular lineages arisen from the mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs), that determine the homeostasis of bone and bone marrow. Here we reasoned that osteocyte may exert a function in regulation of these lineage cell specifications and tissue homeostasis. Using a mouse model of conditional deletion of osteocytes by the expression of diphtheria toxin subunitΒ </span><span>πΌ</span><span> (DTA) in dentin matrix protein 1 (DMP1) positive osteocytes, we demonstrated that partial ablation of DMP1 positive osteocytes caused severe sarcopenia, osteoporosis and degenerative kyphosis, leading to shorter lifespan in these animals. Osteocytes' reduction altered mesenchymal lineage commitment resulting in impairment of osteogenesis and induction of osteoclastogensis. Single cell RNA sequencing further revealed that hematopoietic lineage was mobilized towards myeloid lineage differentiation with expanded myeloid progenitors, neutrophils and monocytes, while the lymphopoiesis was impaired with reduced B cells in the osteocyte ablation mice. The acquisition of a senescence-associated secretory phenotype (SASP) in both osteoprogenic and myeloid lineage cells was the underlying cause. Together, we showed that osteocytes play critical roles in regulation of lineage cell specifications in bone and bone marrow through mediation of senescence.</span></p>
Study of Autologous Bone Marrow Derived Mononuclear Cells for Treatment of Ebstein Anomaly
ClinicalTrials.gov study NCT02914171. IPD Sharing: NO. Countries: 1. Publications: 1.
In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells
ClinicalTrials.gov study NCT03384108. IPD Sharing: NO. Countries: 1. Publications: 1.
Clinical and Radiological Outcomes of Subchondroplasty in the Treatment of Bone Marrow Edema of the Knee
ClinicalTrials.gov study NCT04905394. IPD Sharing: NO. Countries: 1. Publications: 1.
Intramyocardial Transplantation of Bone Marrow Stem Cells in Addition to Coronary Artery Bypass Graft (CABG) Surgery
ClinicalTrials.gov study NCT00950274. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Safety Study of HLA-haplo Matched Allogenic Bone Marrow Derived Stem Cell Treatment in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT01758510. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Bone Marrow Suppression and Recovery During Radionuclide Treatment
ClinicalTrials.gov study NCT03247010. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke
ClinicalTrials.gov study NCT01468064. IPD Sharing: Not stated. Countries: 1. Publications: 3.
To Study the Safety and Efficacy of Autologous Bone Marrow Stem Cells in Patients With Spinal Cord Injury
ClinicalTrials.gov study NCT01730183. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Case Series on Using Bone Marrow Concentrate for Alar Ligament Injuries
ClinicalTrials.gov study NCT03557606. IPD Sharing: NO. Countries: 1. Publications: 4.
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
ClinicalTrials.gov study NCT02144987. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Adherence, Viability, Clinical Evolution and Therapeutic Efficacy in Patients Undergoing Bone Marrow Transplantation
ClinicalTrials.gov study NCT06134297. IPD Sharing: NO. Countries: 1. Publications: 42.
Bone Marrow-derived Cells' Contribution to Tumor Formation and Inflammation
ClinicalTrials.gov study NCT00452205. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intra-arterial Bone-marrow Mononuclear Cells Infusion for Acute Ischemic Stroke
ClinicalTrials.gov study NCT02178657. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Skeletal Health and Bone Marrow Composition in Newly Diagnosed Adolescents With Crohn Disease
ClinicalTrials.gov study NCT04508088. IPD Sharing: NO. Countries: 1. Publications: 53.
Allogeneic Human Bone Marrow Derived Mesenchymal Stem Cells in Localized Prostate Cancer
ClinicalTrials.gov study NCT01983709. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bone Marrow Aspirate Concentrate Versus Triamcinolone Injection For Hip Osteoarthritis
ClinicalTrials.gov study NCT04990128. IPD Sharing: NO. Countries: 1. Publications: 22.
Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis
ClinicalTrials.gov study NCT00855400. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ex Vivo Cultured Bone Marrow Derived Allogenic MSCs in AMI
ClinicalTrials.gov study NCT00883727. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Autologous Bone Marrow Stem Cells for Children With Autism Spectrum Disorders
ClinicalTrials.gov study NCT01740869. IPD Sharing: NO. Countries: 1. Publications: 10.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.