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14,866 results for “cancer cell”
A Study of Brigatinib in Participants With Anaplastic Lymphoma Kinase-Positive (ALK+), Advanced Non-Small-Cell Lung Cancer (NSCLC) Progressed on Alectinib or Ceritinib
ClinicalTrials.gov study NCT03535740. IPD Sharing: YES. Countries: 15. Publications: 3.
Study of Safety and Efficacy of EGFR-TKI EGF816 in Combination With cMET Inhibitor INC280 in Adult Patients With EGFR Mutated Non Small Cell Lung Cancer.
ClinicalTrials.gov study NCT02335944. IPD Sharing: YES. Countries: 11. Publications: 2.
A Study of Mobocertinib in Japanese Adults With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT03807778. IPD Sharing: YES. Countries: 1. Publications: 1.
Study of Oral cMET Inhibitor INC280 in Patients With EGFR Wild-type (wt), Advanced Non-small Cell Lung Cancer (NSCLC) (Geometry Mono-1)
ClinicalTrials.gov study NCT02414139. IPD Sharing: YES. Countries: 20. Publications: 3.
The kinase ERK plays a conserved dominant role in the heterogeneity of epithelial-mesenchymal transition in pancreatic cancer cells
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Supplementary data from: Inherent single-cell heterogeneity of the transcriptional response to hypoxia in cancer cells
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CD8+ T cell-derived CD40L mediates non-canonical cytotoxicity in CD40-expressing cancer cells
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Assessing consistency across functional screening datasets in cancer cells
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Data from: Identification of a minority population of LMO2+ breast cancer cells that integrate into the vasculature and initiate metastasis.
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CD45+ cells from human bladder cancer specimens
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Evaluation of the impact of imprinted polymer particles on morphology and motility of breast cancer cells by using digital holographic cytometry
<p>Supplemented Videos used in "Evaluation of the impact of imprinted polymer particles on morphology and motility of breast cancer cells by using digital holographic cytometry"</p>
Filtered and annotated SNV and indel variants in the PC3 and LNCaP human prostate cancer cell lines
<p>150bp paired-end reads (insert size 350bp) were obtained using the Illumina HiSeqX sequencer. Samtools v1.3.1 mpileup and bcftools were used to interrogate indexed BAM files, from whole-genome reads aligned to human reference genome GRCh38 build 82, and generate a VCF (Variant Call Format) file of single nucleotide variants (SNVs) and short indel variants. Variants private, or unique to a particular cell line, or shared by both were next identified. Variants (likely to be common germline variants) present in HapMap, 1000 genomes phase 3 (2,504 human genomes), and the National Heart Lung and Blood Institute’s Exome Sequencing Project (ESP) (bundled variant data file available at https://goo.gl/mEogvD) were excluded. Variant files (VCF) were filtered using SnpSift with the following parameters: 'QUAL \textgreater= 200 \&\& DP \textgreater= 30', where QUAL denotes minimum variance confidence and DP total depth threshold. Filtered variants were annotated using SnpEff v4.3g. Please see https://github.com/sciseim/PCaWGS for associated scripts.</p> <p> </p>
de novo genome assembly of the LNCaP human prostate cancer cell line
<p>Whole-genome sequencing reads from the LNCaP human prostate cancer cell line were used to generate a <em>de novo </em>assembly with SGA v0.10.15. Please see https://github.com/sciseim/PCaWGS for associated scripts. Library preparation was performed using a TruSeq Nano DNA kit (Illumina) with a target insert size of 350bp. Paired-end libraries (150bp) were sequenced using a HiSeqX sequencer (Illumina).</p>
de novo genome assembly of the PC3 human prostate cancer cell line
<p>Whole-genome sequencing reads from the PC3 human prostate cancer cell line were used to generate a <em>de novo </em>assembly with SGA v0.10.15. Please see https://github.com/sciseim/PCaWGS for associated scripts. Library preparation was performed using a TruSeq Nano DNA kit (Illumina) with a target insert size of 350bp. Paired-end libraries (150bp) were sequenced using a HiSeqX sequencer (Illumina).</p> <p> </p> <p> </p> <p> </p>
Supplementary dataset for journal article "De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition"
<p>Supplementary material for the journal article "De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition".<br> 13C Metabolic flux analyses of CDK4/6 knockdown HCT116 cells and control HCT116 cells performed using INCA v1.5 (Young, J. D., 2014, INCA: a computational platform for isotopically non-stationary metabolic flux analysis. Bioinformatics 30, 1333-1335; http://mfa.vueinnovations.com.) running with MATLAB R2012b. The two files were generated by INCA with the estimated flux map distributions, network model, and tracer simulations.</p>
Pan-cancer analyses refine the single-cell portrait of tumor-infiltrating dendritic cells
<p>This is the dataset for "Pan-cancer Analyses Refine the Single-Cell Portrait of Tumor-Infiltrating Dendritic Cells".</p> <p>File "panDC_all_h5ad.gz" contains processed expression .h5ad data.</p> <p>File "panDC_metadata.csv" contains the meta data for this study.</p>
Effect of Digoxin on clusters of circulating tumor cells in patients with metastatic breast cancer: a phase 1 trial
<p>This repository contains processed transcriptomics data, large data sets and additional files required to reproduce the code available at the repository https://github.com/TheAcetoLab/dicct-trial</p>
Multimodal Epigenetic Sequencing Analysis (MESA) of Cell-free DNA for Non-invasive Colorectal Cancer Detection
<p>Processed data (feature-by-sample matrices) of non-disruptive bisulfite-free methylation sequencing for cfDNA samples from 4 clinical cohorts (Cohort 1, Cohort 2, Cohort 3, and cfTAPS dataset). Codes used to repeat the results in our paper can be found https://rpubs.com/LiYumei/926228 and https://github.com/ChaorongC/MESA. </p>
Generation of KRAS knockout pancreatic cancer cell line PANC1
<p>We used CRISPR to inactivate mutant KRAS and STAT3 in PANC1 (KRASG12D) pancreatic cancer cell line. Gene expression analysis of KRAS intact vs. knockout cells identified sets of genes involved in protein synthesis, cell differentiation, and metabolic processes, while the expression of MAPK/ERK target genes remained unperturbed.</p>
Molecular dynamics dataset for pharmacological repositioning in the treatment of non-small-cell lung cancer
<p><span>Non-small cell lung cancer (NSCLC) is a type of lung cancer associated with translocation of the EML4 and ALK genes on the short arm of chromosome 2. This leads to the development of an aberrant protein kinase with a deregulated catalytic domain, the cdALK<sup>+</sup>. Currently, different ALK inhibitors (iALKs) have been proposed to treat ALK<sup>+ </sup>NSCLC patients.</span> <span>However, the recent resistance to iALKs stimulates the exploration of new iALKs for NSCLC. Here, we describe an <em>in silico</em> approach to finding FDA-approved drugs that can be used by pharmacological repositioning as iALK. We used homology modelling to obtain a structural model of cdALK<sup>+</sup> protein and then performed molecular docking and molecular dynamics of the complex cdALK<sup>+</sup>-iALKs to generate the pharmacophore model. The pharmacophore was used to identify potential iALKs from FDA-approved drugs library by ligand-based virtual screening. Four pharmacophores with different atomistic characteristics were generated, resulting in six drugs that satisfied the proposed atomistic positions</span> <span>and coupled at the ATP-binding site. Mitoxantrone, riboflavin and abacavir exhibit the best interaction energies with 228.29, 165.40 and 133.48 kjoul/mol respectively. In addition, the special literature proposed these drugs for other types of diseases due to pharmacological repositioning. This study proposes FDA-approved drugs with ALK inhibitory characteristics. Moreover, we identified pharmacophores sites that can be tested with other pharmacological libraries</span><span>.</span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.