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2,678 results for “cell signalling”
Transcriptome for: MYB42 inhibits hypocotyl cell elongation by coordinating brassinosteroid homeostasis and signaling in Arabidopsis
<p><span>The precise control of brassinosteroids (BRs) homeostasis and signaling is a prerequisite for hypocotyl cell elongation in plants. Little is known, however, of such regulators of BR homeostasis and signaling. Here, we have demonstrated that MYB42 negatively regulates hypocotyl elongation through partial inhibition of BRASSINAZOLE-RESISTANT 1 (BZR1) signaling and promotion of BR inactivation. Transgenic <i><span>Arabidopsis</span></i> plants repressing the expression of <i><span>MYB42</span></i> and its paralog <i><span>MYB85</span></i> (<i><span>MYB85 RNAi;myb42</span></i>) exhibited longer hypocotyls than wild-type (WT) plants in darkness, while <i><span>MYB42</span></i> or <i><span>MYB85 </span></i>overexpression inhibits hypocotyl elongation. Hypocotyl length of <i><span>MYB85 RNAi;myb42 </span></i><span>plants can</span><i> </i><span>be </span>resorted <span>into WT level by </span><i><span>MYB42 </span></i>overexpression<span>. </span><span>MYB</span><span>42</span> inhibits hypocotyl elongation by mediating BR signaling, because <i><span>MYB42 </span></i>expression is repressed with BR treatment and in the dominant BR mutant <i><span>bzr1-1D</span></i><span>,</span> and <span>mutation of</span><i> </i><span>both</span><i><span> MYB42</span></i><span> and </span><i><span>MYB85 </span></i>enhances the dwarf phenotype of the BR receptor mutant <i><span>bri1-5</span></i><span>. BZR1 directly represses </span><i><span>MYB42 </span></i><span>expression in response to BR, and </span>t<span>he</span><i> </i><span>hypocotyl length of </span><i><span>bzr1-1D</span></i> is reduced in <i><span>MYB42</span></i><span> overexpression plants but increased in</span><i><span> MYB85 RNAi;myb42 </span></i><span>plants. These results show </span><span><span>MYB42 is a negative target of BZR1</span></span><span>. Transcriptome data revealed that</span><span><span> a number of</span></span><span> BZR1-induced </span>genes associated with <span>cell elongation are down-regulated by MYB42, suggesting that </span><span><span>MYB42</span></span> may partially inhibit BZR1 signaling. In addition, MYB42 enlarges its action in BR signaling through feedback activation of <span>the </span>BR-inactivating enzyme<span> DOGT1</span>. The present study shows a MYB42-mediated multilevel system that contributes to fine regulation of BR-induced hypocotyl elongation.</span></p>
Eupatorin modulates BCPAP in thyroid cancer cell proliferation via suppressing the NF-κB/P13K/AKT signaling pathways
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CircRPPH1 promotes cell proliferation, migration and invasion of non-small cell lung cancer (NSCLC) via the PI3K/AKT and JAK2/STAT3 signaling axes
<p>original numerical data before creating graphs</p>
Data from: Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
In the epithelial follicle stem cells (FSCs) of the Drosophila ovary, Epidermal Growth Factor Receptor (EGFR) signaling promotes self-renewal, whereas Notch signaling promotes differentiation of the prefollicle cell (pFC) daughters. We have identified two proteins, Six4 and Groucho (Gro), that link the activity of these two pathways to regulate the earliest cell fate decision in the FSC lineage. Our data indicate that Six4 and Gro promote differentiation towards the polar cell fate by promoting Notch pathway activity. This activity of Gro is antagonized by EGFR signaling, which inhibits Gro-dependent repression via p-ERK mediated phosphorylation. We have found that the phosphorylated form of Gro persists in newly formed pFCs, which may delay differentiation and provide these cells with a temporary memory of the EGFR signal. Collectively, these findings demonstrate that phosphorylated Gro labels a transition state in the FSC lineage and describe the interplay between Notch and EGFR signaling that governs the differentiation processes during this period.
Data from: RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells
The Golgi apparatus has many important physiological functions, including sorting of secretory cargo and biosynthesis of complex glycans. These functions depend on the intricate and compartmentalized organization of the Golgi apparatus. To investigate the mechanisms that regulate Golgi architecture, we developed a quantitative morphological assay using three different Golgi compartment markers and quantitative image analysis, and performed a kinome- and phosphatome-wide RNAi screen in HeLa cells. Depletion of 159 signaling genes, nearly 20% of genes assayed, induced strong and varied perturbations in Golgi morphology. Using bioinformatics data, a large regulatory network could be constructed. Specific subnetworks are involved in phosphoinositides regulation, acto-myosin dynamics and mitogen activated protein kinase signaling. Most gene depletion also affected Golgi functions, in particular glycan biosynthesis, suggesting that signaling cascades can control glycosylation directly at the Golgi level. Our results provide a genetic overview of the signaling pathways that control the Golgi apparatus in human cells.
Heat oscillations driven by the embryonic cell cycle reveal the energetic costs of signaling
<p>R scripts and calorimetry data used and generated in "Heat oscillations driven by the embryonic cell cycle reveal the energetic costs of signaling" by Rodenfels <em>et al. </em></p>
Upregulation of SALL4-regulated BDNF Modulates Hedgehog Signaling to Promote Epithelial-mesenchymal Transition and Inhibit Carboplatin Sensitivity in Colon Adenocarcinoma Cells
<p>Individual uncropped, unprocessed image for western blot</p>
Fig. 1 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 1. Chemical structures of 1–28.
Fig. 2 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 2. Key correlations in the HMBC spectra of compounds 1, 2 and 3.
Fig. 6 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 6. Effect of compounds 5, 7 and 8 on SMMC7721 cell cycle progression. *P <0.05 vs control.
Fig. 4. X-ray crystallographic data for 1 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 4. X-ray crystallographic data for 1.
Fig. 3 in Triterpenoids from Liquidambar Fructus induced cell apoptosis via a PI3KAKT related signal pathway in SMMC7721 cancer cells
Fig. 3. Selected NOE correlations of compounds 1, 2 and 3.
Cell Signaling, Reinnervation and Metabolism in Kennedy Disease and Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT05107349. IPD Sharing: YES. Countries: 1. Publications: 0.
Continuous 24h Intravenous Infusion of Mithramycin, an Inhibitor of Cancer Stem Cell Signaling, in People With Primary Thoracic Malignancies or Carcinomas, Sarcomas or Germ Cell Neoplasms With Pleurop
ClinicalTrials.gov study NCT02859415. IPD Sharing: YES. Countries: 1. Publications: 0.
Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
ClinicalTrials.gov study NCT05672030. IPD Sharing: NO. Countries: 1. Publications: 0.
Data from: RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells
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Data from: Systematic study of the surface plasmon resonance signals generated by cells for sensors with different characteristic lengths
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Data from: Nitric oxide signals are interlinked with calcium signals in normal pancreatic stellate cells upon oxidative stress and inflammation
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Data from: Phosphorylated Groucho delays differentiation in the follicle stem cell lineage by providing a molecular memory of EGFR signaling in the niche
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Data from: B cell receptor and Toll-like receptor signaling coordinate to control distinct B-1 responses to both self and the microbiota
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.