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784 results for “dermal”
Figure 5. A–D in Sculpture and vascularization of dermal bones, and the implications for the physiology of basal tetrapods
Figure 5. A–D, drawings of dermal sculpture and imprints of vessels. A, Mastodonsaurus giganteus (Stereospondyli, Capitosauroidea), SMNS 80878. Part of?nasal with imprints of large, branching vessels. B, Trimerorhachis insignis (Temnospondyli, Dvinosauria), MCZ 8286. Dermal sculpture in the region of the junction between the tabular, supratemporal, and postparietal. C, Cochleosaurus bohemicus (Temnospondyli, Edopoidea), MB.Am.80. Dermal sculpture of postparietal lappet. D, Captorhinus sp. (Eureptilia, Captorhinidae), UCMP 202967. Part of dermal skull roof with cells and furrows. For abbreviations, see text.
Human dermal microvascular arterial and venous blood endothelial cells and their use in bioengineered dermo-epidermal skin substitutes in vitro and in vivo
<p>The bio-engineering of vascular networks is pivotal to create complex tissues and</p> <p>organs in vitro for regenerative medicine applications. The vascular plexus is needed for a</p> <p>sufficient and fast blood supply after transplantation, and, thus, required for the survival and</p> <p>function of the engineered tissue or organ. Hence, human endothelial cells are an attractive</p> <p>source for bio-engineering purposes, for example human dermal microvascular endothelial</p> <p>cells (HDMECs).</p> <p>So far, a discrimination between arterial and venous blood endothelial cells after</p> <p>isolation of HDMECs from skin biopsies and if arterial and/or venous capillaries are formed in</p> <p>pre-vascularized bio-engineered substitutes was not investigated.</p> <p>In this study, we investigated employedby single cell sequencing for to</p> <p>investigate/compare human arterial and venous endothelial cell markers in human fetal and</p> <p>juvenile skin. Further, we analyzed if these markers are present after isolation of human skin</p> <p>derived endothelial cells under 2D culture conditions. In additionFinally, we investigated</p> <p>assessed if human endothelial cells form distinct arterial and venous capillaries in 3D</p> <p>collagen type I hydrogels, and if these capillaries retain their identity after transplantation.</p> <p>We determinedOur results showed that arterial and venous endothelial cell markers</p> <p>such as NRP1 and NR2F2 are expressed both in fetal and juvenile skin, and are retained after</p> <p>isolation in culture. We could show demonstrate that arterial and venous endothelial cells</p> <p>maintain their differentiation status and form arterial and venous capillaries in 3D in vitro</p> <p>culture systems and that the capillaries inosculate after transplantation.</p> <p>In summary, we could show that we could bio-engineer human arterial, venous, and</p> <p>lymphatic capillaries in a human skin substitute in view of regenerative medicine approaches</p> <p>for clinical applications.</p>
Intra-dermal With Topical Imiquimod Pretreatment Versus Intra-muscular Hepatitis B Vaccination in IBD Patients
ClinicalTrials.gov study NCT04083157. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Dermal Allograft Augmentation of Large and Massive Rotator Cuff Tears
ClinicalTrials.gov study NCT05981833. IPD Sharing: NO. Countries: 1. Publications: 11.
Feasibility Study of the Effect of Intra-Dermal Insulin Injection on Blood Glucose Levels After Eating
ClinicalTrials.gov study NCT00553488. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluating the Performance and Safety of the Medical Device Plenhyage® in the Treatment of Dermal Tissue Defects
ClinicalTrials.gov study NCT05239117. IPD Sharing: Not stated. Countries: 1. Publications: 41.
EVOLENCE® Assessment of Recovery Time and Impact of Dermal Filler Selection: The E-ART™ Study
ClinicalTrials.gov study NCT00911872. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Influence of Hydrochlorothiazide on Dermal Photosensitivity and DNA Stability - a Pilot Study (HCTox Study)
ClinicalTrials.gov study NCT04654312. IPD Sharing: NO. Countries: 1. Publications: 1.
Diagnostic Accuracy of Dermal Thickness in Lymphedema
ClinicalTrials.gov study NCT03676127. IPD Sharing: NO. Countries: 1. Publications: 4.
Aesthetic Outcome of Intra-dermal Versus Transcutaneous Purse-string Closure
ClinicalTrials.gov study NCT06448481. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Short Term Status of Free Dermal Fat Autografts for Complex Craniofacial Wounds
ClinicalTrials.gov study NCT03872544. IPD Sharing: NO. Countries: 1. Publications: 1.
Distribution of Secukinumab (AIN457) Into Dermal Interstitial Fluid After a Single Subcutaneous Administration of 300 mg
ClinicalTrials.gov study NCT01539213. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dermal Thermometry and Self-Care of High Risk Diabetic Patients
ClinicalTrials.gov study NCT00105755. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Effect of Soft Tissue Augmentation With an Acellular Dermal Matrix in Marginal Bone Levels Around Implants
ClinicalTrials.gov study NCT05156294. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Dermal Micrografts in Regenerative Surgery
ClinicalTrials.gov study NCT03912675. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Adjunctive Use of Dermal Matrix to Compensate Dimensional Changes in the Reconstructive Therapy of Peri-implantitis
ClinicalTrials.gov study NCT06398288. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Evaluating the Performance and Safety of the Medical Device Auralya® in the Treatment of Facial Dermal Tissue Defects
ClinicalTrials.gov study NCT05239130. IPD Sharing: Not stated. Countries: 1. Publications: 32.
An Exploratory Study in Healthy Volunteers to Investigate the Cross-talk Between Local Drug Concentrations in the Skin and Systemic Concentrations During Topical Bioequivalence Studies Using Dermal Sa
ClinicalTrials.gov study NCT03813030. IPD Sharing: NO. Countries: 1. Publications: 5.
Root Coverage in Smokers With Acellular Dermal Matrix Graft and Enamel Matrix Derivative
ClinicalTrials.gov study NCT02135471. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Toxicokinetic Study of Dichlorobisphenol A After an Oral or Dermal Single Dose in Healthy Volunteer.
ClinicalTrials.gov study NCT04788810. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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