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119
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ShareScore release 0.9.0
Dataset results
119 results for “disease susceptibility”
Next-generation interaction screening to discover Mla6aa1-161 and Mla6aa1-225, Mla6aa550-956 related protein-protein interactions regulating barley powdery mildew disease immunity and susceptibility.
GEO Series GSE164818. Blumeria hordei; Hordeum vulgare. 18 samples. Type: Other.
Cooler temperatures destabilize RNA interference and increase susceptibility of disease vector mosquitoes to viral infection
GEO Series GSE46204. Aedes aegypti; Aedes albopictus. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Multifunctional Substrate for Early Detection of Oxidative Stress Susceptibility and Application to Parkinson's Disease
ClinicalTrials.gov study NCT00271141. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Longitudinal Quantitative Susceptibility Mapping (QSM) in Alzheimer 's Disease
ClinicalTrials.gov study NCT02752750. IPD Sharing: NO. Countries: 0. Publications: 0.
Gene expression analysis of host spleen responses to Marek's disease virus infection in susceptible and resistant chickens
GEO Series GSE29805. Gallus gallus. 12 samples. Type: Expression profiling by array.
Myeloid PDLIM2 repression as a common causal mechanism of lung disease pathogenesis and susceptibility to infection
GEO Series GSE249800. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomics study of resistant and susceptible wheat lines to tan spot disease (Pyrenophora tritici-repentis)
GEO Series GSE202986. Triticum aestivum. 36 samples. Type: Expression profiling by high throughput sequencing.
Rare germline copy number variations and disease susceptibility in familial melanoma
GEO Series GSE85010. Homo sapiens. 254 samples. Type: Genome variation profiling by SNP array; Genome variation profiling by genome tiling array.
Next-generation interaction screening to discover CSEP0491 related protein-protein interactions regulating barley powdery mildew disease immunity and susceptibility.
GEO Series GSE166108. Blumeria hordei; Hordeum vulgare. 6 samples. Type: Other.
A protein network of common susceptibility genes provides a link in the genetic architecture of chronic inflammation and cardiovascular disease
GEO Series GSE54989. Homo sapiens. 6 samples. Type: Expression profiling by array.
Next-generation interaction screening to discover AVRA1 related protein-protein interactions regulating barley powdery mildew disease immunity and susceptibility.
GEO Series GSE164954. Hordeum vulgare; Blumeria hordei. 6 samples. Type: Expression profiling by high throughput sequencing.
Cell and state-specific eQTL analysis in human endometrial mesenchymal cells uncovers candidate susceptibility genes for reproductive diseases and traits
GEO Series GSE251756. Homo sapiens. 59 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor's Disease Susceptibility
<p>We characterized transcriptional variability from a hiPSC-derived cardiomyocyte (hiPSC-CM) study of left ventricular hypertrophy (LVH) using donor samples from the HyperGEN study. Multiple hiPSC-CM cell lines were used to assess variabilities from reprogramming, differentiation, and donors. Variability arising from pathological alterations was assessed using a cardiac stimulant applied to the hiPSC-CMs to trigger hypertrophic responses. We found that for most genes (73.3%~85.5%), technical variability was smaller than biological variability. Further, we identified and characterized lists of "noise" genes showing greater technical variability and "signal" genes showing greater biological variability. Together, they support a "genetic robustness" hypothesis of disease-modeling whereby cellular response to relevant stimuli in hiPSC-derived somatic cells from diseased donors tends to show more transcriptional variability. Our findings suggest that hiPSC-CMs can provide a valid model for cardiac hypertrophy and distinguish between technical and disease-relevant transcriptional changes.</p>
Exploring Origin-dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases via Intersectional Genetics
GEO Series GSE278774. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Profiling of Meq-dependent Genes in Marek’s Disease Resistant and Susceptible Inbred Chicken Lines
GEO Series GSE48453. Gallus gallus. 36 samples. Type: Expression profiling by array.
Fetal cell microchimerism and susceptibility to COVID-19 disease in women.
<p>Dataset of "Cirello V, Lugaresi M, Manzo A, Balla E, Fratianni G, Solari F, Persani L, Fugazzola L, Campi I. Fetal cell microchimerism and susceptibility to COVID-19 disease in women. Infection. 2023;51:1071-1078. doi: 10.1007/s15010-023-02006-x."</p> <p>Abstract<br>Purpose The clinical outcome of COVID-19 disease is worse in males, and the reasons of this gender disparity are currently unclear, though evidences point to a combination of biological and gender-specifc factors. A phenomenon unique to<br>the female gender is the fetal cell microchimerism (FCM), defned as the presence of fetal microchimeric cells in maternal<br>organs and in the circulation for years after delivery and usually evaluated by assessing the presence of male cells or DNA<br>in a woman. In the present case–control study, we aimed to evaluate the possible efect of pregnancy and related FCM on<br>the susceptibility to SARS-CoV-2 infection and on the clinical course and outcome of COVID-19.<br>Methods One hundred twenty-three women with a previous male pregnancy, comprising 63 COVID-19 cases and 60 healthy<br>controls were enrolled. The presence of blood male DNA was assessed by the amplifcation of the Y-chromosome specifc<br>gene SRY.<br>Results The prevalence of male DNA of presumed fetal origin was signifcantly higher in healthy controls than in COVID-19<br>cases (70 vs 44.4%, P=0.0044; OR 0.3429, 95% CI 0.1631–0.7207, P=0.0047). Among women afected with COVID-19,<br>the presence of male FCM did not signifcantly infuence the severity of the disease, though the 8 deceased women studied<br>were all FCM negative.<br>Conclusion This is the frst case–control study reporting the prevalence of FCM in COVID-19 and healthy women. Overall,<br>our data seem to suggest a role for FCM in the protection towards the SARS-CoV-2 infection with a possible positive impact<br>on clinical outcome.</p>
Association of rs3027178 polymorphism in the circadian clock gene PER1 with susceptibility to Alzheimer's disease and longevity in an Italian population
<p>Many physiological processes in the human body follow a 24-h circadian rhythm controlled by the circadian clock system. Light, sensed by retina, is the predominant "zeitgeber" able to synchronize the circadian rhythms to the light-dark cycles. Circadian rhythm dysfunction and sleep disorders have been associated with aging and neurodegenerative diseases including mild cognitive impairment (MCI) and Alzheimer's disease (AD). In the present study, we aimed at investigating the genetic variability of clock genes in AD patients compared to healthy controls from Italy. We also included a group of Italian centenarians, considered as super-controls in association studies given their extreme phenotype of successful aging. We analyzed the exon sequences of eighty-four genes related to circadian rhythms, and the most significant variants identified in this first discovery phase were further assessed in a larger independent cohort of AD patients by matrix assisted laser desorption/ionization-time of flight mass spectrometry. The results identified a significant association between the rs3027178 polymorphism in the PER1 circadian gene with AD, the G allele being protective for AD. Interestingly, rs3027178 showed similar genotypic frequencies among AD patients and centenarians. These results collectively underline the relevance of circadian dysfunction in the predisposition to AD and contribute to the discussion on the role of the relationship between the genetics of age-related diseases and of longevity.</p>
Analysis of Potato Smooth Skin Mutant Susceptible to Powdery Scab Disease
GEO Series GSE10485. Solanum tuberosum. 15 samples. Type: Expression profiling by array.
A functional link between Enhanced Disease Susceptibility 1 and GH3.12/avrPphB susceptible 3 in pattern-triggered immunity in plants
GEO Series GSE159523. Arabidopsis thaliana. 42 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.