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231
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231 results for “functional connectivity”
Data from: Optimizing the trade-off between spatial and genetic sampling efforts in patchy populations: towards a better assessment of functional connectivity using an individual-based sampling scheme
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Data from: Marine protected area restricts demographic connectivity: dissimilarity in a marine environment can function as a biological barrier
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Integrating functional connectivity in designing networks of protected areas under climate change: a caribou case-study
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Data from: Replicated landscape genetic and network analyses reveal wide variation in functional connectivity for American pikas
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Data from: Seed dispersal by dispersing juvenile animals: a source of functional connectivity in fragmented landscapes
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Data from: Beyond isolation by distance: what best explains functional connectivity among populations of three sympatric plant species in an ancient terrestrial island system?
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Predictive utility of task-related functional connectivity vs. voxel activation - Data and code archive
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Data from: Assessing changes in functional connectivity in a desert bighorn sheep metapopulation after two generations
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Data from: Fencing solves human‐wildlife conflict locally but shifts problems elsewhere: a case study using functional connectivity modelling of the African elephant
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Data from: Assessing the permeability of landscape features to animal movement: using genetic structure to infer functional connectivity
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Maximum entropy model estimates functional connectivity
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Data from: Functional connectivity in replicated urban landscapes in the land snail (Cornu aspersum)
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Data from: Loss of functional connectivity in migration networks induces population decline in migratory birds
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Data from: Ditch network sustains functional connectivity and influences patterns of gene flow in an intensive agricultural landscape
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Data from: Brain states govern the spatio-temporal dynamics of resting-state functional connectivity
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Functional connectivity in a continuously distributed, migratory species as revealed by landscape genomics
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Data from: Cognitive correlates of cerebellar resting-state functional connectivity in Parkinson disease.
Objective: The purpose of this cross-sectional study was to investigate the contributions of altered cerebellar resting-state functional connectivity (FC) to cognitive impairment in Parkinson disease (PD). Methods: We conducted morphometric and resting-state functional connectivity MRI (FC-MRI) analyses contrasting 81 PD and 43 age-matched healthy controls using rigorous quality assurance measures. To investigate the relationship of cerebellar FC to cognitive status, we compared PD participants without cognitive impairment (Clinical Dementia Rating scale, CDR=0; n=47) to PD participants with impaired cognition (CDR≥0.5; n=34). Comprehensive measures of cognition across the five cognitive domains were assessed for behavioral correlations. Results: The PD participants had significantly weaker FC between the vermis and peristriate visual association cortex compared to controls, and the strength of this FC correlated with visuospatial function and global cognition. In contrast, weaker FC between vermis and dorsolateral prefrontal cortex was found in the cognitively impaired PD group compared to PD participants without cognitive impairment. This effect correlated with deficits in attention, executive functions and global cognition. No group differences in cerebellar lobular volumes or regional cortical thickness of the significant cortical clusters were observed. Conclusion: These results demonstrate a correlation between cerebellar vermal FC and cognitive impairment in PD. The absence of significant atrophy in cerebellum or relevant cortical areas suggests this could be related to local pathophysiology such as neurotransmitter dysfunction.
Data from: Social interactions elicit rapid shifts in functional connectivity in the social decision-making network of zebrafish
According to the social decision-making (SDM) network hypothesis, SDM is encoded in a network of forebrain and midbrain structures in a distributed and dynamic fashion, such that the expression of a given social behaviour is better reflected by the overall profile of activation across the different loci rather than by the activity of a single node. This proposal has the implicit assumption that SDM relies on integration across brain regions, rather than on regional specialization. Here we tested the occurrence of functional localization and of functional connectivity in the SDM network. For this purpose we used zebrafish to map different social behaviour states into patterns of neuronal activity, as indicated by the expression of the immediate early genes c-fos and egr-1, across the SDM network. The results did not support functional localization, as some loci had similar patterns of activity associated with different social behaviour states, and showed socially driven changes in functional connectivity. Thus, this study provides functional support to the SDM network hypothesis and suggests that the neural context in which a given node of the network is operating (i.e. the state of its interconnected areas) is central to its functional relevance.
Data from: Altered fronto-temporal functional connectivity in individuals at ultra-high-risk of developing psychosis
Background: The superior temporal gyrus (STG) is one of the key regions implicated in psychosis, given that abnormalities in this region are associated with an increased risk of conversion from an at-risk mental state to psychosis. However, inconsistent results regarding the functional connectivity strength of the STG have been reported, and the regional heterogeneous characteristics of the STG should be considered. Methods: To investigate the distinctive functional connection of each subregion in the STG, we parcellated the STG of each hemisphere into three regions: the planum temporale, Heschl's gyrus, and planum polare. Resting-state functional magnetic resonance imaging was obtained from 22 first-episode psychosis (FEP) patients, 41 individuals at ultra-high-risk for psychosis (UHR), and 47 demographically matched healthy controls. Results: Significant group differences (in seed-based connectivity) were demonstrated in the left planum temporale and from both the right and left Heschl's gyrus seeds. From the left planum temporale seed, the FEP and UHR groups exhibited increased connectivity to the bilateral dorsolateral prefrontal cortex. In contrast, the FEP and UHR groups demonstrated decreased connectivity from the bilateral Heschl's gyrus seeds to the dorsal anterior cingulate cortex. The enhanced connectivity between the left planum temporale and right dorsolateral prefrontal cortex was positively correlated with positive symptom severity in individuals at UHR (r = .34, p = .03). Conclusions: These findings corroborate the fronto-temporal connectivity disruption hypothesis in schizophrenia by providing evidence supporting the altered fronto-temporal intrinsic functional connection at earlier stages of psychosis. Our data indicate that subregion-specific aberrant fronto-temporal interactions exist in the STG at the early stage of psychosis, thus suggesting that these aberrancies are the neural underpinning of proneness to psychosis.
Data from: Selective modulation of interhemispheric functional connectivity by HD-tACS shapes perception
Oscillatory neuronal synchronization between cortical areas has been suggested to constitute a flexible mechanism to coordinate information flow in the human cerebral cortex. However, it remains unclear whether synchronized neuronal activity merely represents an epiphenomenon or whether it is causally involved in the selective gating of information. Here, we combined bilateral high-density transcranial alternating current stimulation (HD-tACS) at 40 Hz with simultaneous electroencephalographic (EEG) recordings to study immediate electrophysiological effects during the selective entrainment of oscillatory gamma-band signatures. We found that interhemispheric functional connectivity was modulated in a predictable, phase-specific way: In-phase stimulation enhanced synchronization, anti-phase stimulation impaired functional coupling. Perceptual correlates of these connectivity changes were found in an ambiguous motion task, which strongly support the functional relevance of long-range neuronal coupling. Additionally, our results revealed a decrease in oscillatory alpha power in response to the entrainment of gamma band signatures. This finding provides causal evidence for the antagonistic role of alpha and gamma oscillations in the parieto-occipital cortex and confirms that the observed gamma band modulations were physiological in nature. Our results demonstrate that synchronized cortical network activity across several spatiotemporal scales is essential for conscious perception and cognition.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.