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242
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ShareScore release 0.9.0
Dataset results
242 results for “immune response to cancer;”
THE INTEGRATIVE GENOMIC AND FUNCTIONAL IMMUNOLOGICAL ANALYSES OF COLORECTAL CANCER INITIATING CELLS TO MODULATE STEMNESS PROPERTIES AND THE SUSCEPTIBILIY TO IMMUNE RESPONSES [miRNA]
GEO Series GSE287585. Homo sapiens. 23 samples. Type: Non-coding RNA profiling by array.
Clonal tracing reveals the contribution of both cancer-intrinsic and -extrinsic mechanisms to the heterogeneity of responses to immune checkpoint blockade
GEO Series GSE139476. Mus musculus. 26 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses [Epigenetic CRISPRscreen]
GEO Series GSE189767. Homo sapiens. 6 samples. Type: Other.
DNA methylation-based immune response signature improves patient diagnosis in multiple cancers (Cohort 2)
GEO Series GSE72251. Homo sapiens. 119 samples. Type: Methylation profiling by array.
PIKfyve inhibition upregulates surface expression of MHC class I to enhance immune responses in cancer
GEO Series GSE235945. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Dataset for: Radiation therapy induces innate immune responses in patients treated for prostate cancers
<p><strong>Purpose </strong></p> <p>Radiation therapy (RT) is a curative therapeutic modality used to treat cancers as a single agent or in combination with surgery and chemotherapy. Advanced RT technologies enable treatment with large fraction, highly conformal, radiation doses to effect free-radical damage to cellular DNA leading to cell cycle arrest, cell death, and innate immune response stimulation.</p> <p><strong>Experimental Design </strong></p> <p>To understand systemic clinical responses after radiation exposure, high throughput proteomic and metabolomic analyses were performed on plasma obtained from cancer patients at intervals after prostate stereotactic body radiation therapy. Pathway analysis and multivariate analyses were used to delineate molecular alterations following radiation therapy and its correlation with clinical outcomes.</p> <p><strong>Results</strong></p> <p>DNA Damage Response (DDR) and cell cycle signaling increased within the first hour after treatment and returned to baseline by one month. Innate immune response signaling also increased within one hour of treatment but persisted for up to three months thereafter. Furthermore, robust immune responses and metabolite elevations, consistent with an early proinflammatory M1-mediated innate immune activation, were observed in patients in remission, whereas patients experiencing PSA-determined disease progression demonstrated less robust immune responses and M2-mediated metabolite elevations.</p> <p><strong>Conclusion/Discussion</strong></p> <p>To our knowledge, these data are the first report of longitudinal proteomic and metabolomic molecular responses in patients after radiation therapy for cancers. The data supports innate immune activation as a critical clinical response of patients receiving radiation therapy for prostate cancer. Furthermore, we propose that the observed innate immune responses may be generalized to the treatment of other cancer types, potentially informing multidisciplinary therapeutic strategies for cancer treatment.</p>
Immune Response in Cervical Lymph Nodes of Patients With Head and Neck Cancer
ClinicalTrials.gov study NCT07131566. IPD Sharing: NO. Countries: 1. Publications: 0.
Study to Evaluate Immune Responses in Neurologically Normal Cancer Patients
ClinicalTrials.gov study NCT00481637. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Response to Third Dose of SARS-CoV-2 Vaccine in a Cohort of Cancer Patients on Active Treatment
ClinicalTrials.gov study NCT05119738. IPD Sharing: NO. Countries: 1. Publications: 0.
Bronchoscopy With Bronchoalveolar Lavage in Identifying Biomarkers of Response to Immune Checkpoint Inhibitors in Patients With Non-small Cell or Small Cell Lung Cancer
ClinicalTrials.gov study NCT02937402. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Immune Function and Response to Vaccination After Cancer Therapy in Pediatric Patients
ClinicalTrials.gov study NCT04948619. IPD Sharing: NO. Countries: 1. Publications: 0.
Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer
ClinicalTrials.gov study NCT00001582. IPD Sharing: YES. Countries: 1. Publications: 0.
Impact of Aerobic Exercise on the Anticancer Immune Response in Patients Receiving Cancer Treatment
ClinicalTrials.gov study NCT06911970. IPD Sharing: NO. Countries: 1. Publications: 0.
Immune Profiling for Cancer Immunotherapy Response
ClinicalTrials.gov study NCT06116032. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Pilot Study to Evaluate if Contrast Enhanced Ultrasound (CEUS) Can Predict Treatment Response in Triple Negative Breast Cancer (TNBC) Patients Receiving Combined Chemotherapy and Immune Checkpoint Inh
ClinicalTrials.gov study NCT05957042. IPD Sharing: NO. Countries: 1. Publications: 0.
Immune Response Under Immunotherapy in Lung Cancer: Study of Sputum Samples
ClinicalTrials.gov study NCT07163507. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT01504542. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Response in Patients Who Have Undergone Vaccine Therapy for Stage III or Stage IV Breast Cancer That Overexpresses HER2
ClinicalTrials.gov study NCT00363012. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer
ClinicalTrials.gov study NCT06130826. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Immune System's Response to Young Women's Breast Cancer
ClinicalTrials.gov study NCT01503190. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.