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565
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ShareScore release 0.9.0
Dataset results
565 results for “immunodeficiency”
A Study to Evaluate the Antiviral Effect, Safety and Tolerability of GSK3810109A in Viremic Human Immunodeficiency Virus (HIV)-1 Infected Adults
ClinicalTrials.gov study NCT04871113. IPD Sharing: YES. Countries: 6. Publications: 1.
Efficacy, Safety and Tolerability Study of Long-acting Cabotegravir Plus Long-acting Rilpivirine (CAB LA + RPV LA) in Human-immunodeficiency Virus-1 (HIV-1) Infected Adults
ClinicalTrials.gov study NCT03299049. IPD Sharing: YES. Countries: 13. Publications: 8.
Study to Evaluate Switching From an E/C/F/TAF Fixed-Dose Combination (FDC) Regimen or a TDF Containing Regimen to B/F/TAF FDC in Human Immunodeficiency Virus-1 (HIV-1) Infected Participants Aged ≥ 65
ClinicalTrials.gov study NCT03405935. IPD Sharing: YES. Countries: 5. Publications: 2.
Data from: Feline immunodeficiency virus in puma: estimation of force of infection reveals insights into transmission
Determining parameters that govern pathogen transmission (such as the force of infection, FOI), and pathogen impacts on morbidity and mortality, is exceptionally challenging for wildlife. Vital parameters can vary, for example across host populations, between sexes and within an individual's lifetime. Feline immunodeficiency virus (FIV) is a lentivirus affecting domestic and wild cat species, forming species-specific viral--host associations. FIV infection is common in populations of puma (Puma concolor), yet uncertainty remains over transmission parameters and the significance of FIV infection for puma mortality. In this study the age-specific FOI of FIV in pumas was estimated from prevalence data, and the evidence for disease-associated mortality was assessed. We fitted candidate models to FIV prevalence data and adopted a maximum likelihood method to estimate parameter values in each model. The models with the best fit were determined to infer the most likely FOI curves. We applied this strategy for female and male pumas from southern California, Colorado, and Florida. When splitting the data by sex and area, our FOI modelling revealed no evidence of disease-associated mortality in any population. Both sex and location were found to influence the FOI, which was generally higher for male pumas than for females. For female pumas at all sites, and male pumas from California and Colorado, the FOI did not vary with puma age, implying FIV transmission can happen throughout life; this result supports the idea that transmission can occur from mothers to offspring and also throughout adult life. For Florida males, the FOI was a decreasing function of puma age, indicating an increased risk of infection in the early years, and a decreased risk at older ages. This research provides critical insight into pathogen transmission and impact in a secretive and solitary carnivore. Our findings shed light on the debate on whether FIV causes mortality in wild felids like puma, and our approach may be adopted for other diseases and species. The methodology we present can be used for identifying likely transmission routes of a pathogen and also estimating any disease-associated mortality, both of which can be difficult to establish for wildlife diseases in particular.
Infographic: Secondary Immunodeficiency
<p>Infographic about secondary immunodeficiencies.</p>
A Study of Doravirine (MK-1439) in Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Participants (MK-1439-005)
ClinicalTrials.gov study NCT01466985. IPD Sharing: YES. Countries: 0. Publications: 1.
Primitive Immunodeficiency and Pregnancy
ClinicalTrials.gov study NCT04581460. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Doravirine, Tenofovir, Lamivudine (MK-1439A) in Participants Infected With Treatment-Naïve Human Immunodeficiency Virus (HIV) -1 With Transmitted Resistance (MK-1439A-030)
ClinicalTrials.gov study NCT02629822. IPD Sharing: YES. Countries: 0. Publications: 1.
A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretrovi
ClinicalTrials.gov study NCT04840199. IPD Sharing: YES. Countries: 1. Publications: 0.
A Study of TAK-771 in Japanese People With Primary Immunodeficiency Diseases (PID)
ClinicalTrials.gov study NCT05150340. IPD Sharing: YES. Countries: 1. Publications: 0.
An Efficacy and Safety Study of Grazoprevir (MK-5172) + Elbasvir (MK-8742) in the Treatment of Chronic Hepatitis C Virus in Participants Who Are Co-Infected With Human Immunodeficiency Virus:C-EDGE CO
ClinicalTrials.gov study NCT02105662. IPD Sharing: YES. Countries: 0. Publications: 4.
Acquired Immunodeficiency Syndrome(AIDS) and Tuberculosis(Tb) Co-infection Treatment Strategies Study of China.
ClinicalTrials.gov study NCT01344148. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate the Long-term Safety of TAK-771 in Japanese Primary Immunodeficiency Disease (PID) Participants
ClinicalTrials.gov study NCT05513586. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety, Tolerability and Immunogenicity Study of Different Vaccine Schedules With Ad26.Mos.HIV and Clade C Glycoprotein (gp)140 in Healthy Human Immunodeficiency Virus (HIV)-Uninfected Adults
ClinicalTrials.gov study NCT02685020. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pneumococcal Pneumonia Vaccine Series (PCV20 and PPSV23) in Patients With Chronic Lymphocytic Leukemia Associated Immunodeficiency, PROTECT CLL Trial
ClinicalTrials.gov study NCT05183854. IPD Sharing: NO. Countries: 1. Publications: 0.
Studies of Disorders in Antibody Production and Related Primary Immunodeficiency States
ClinicalTrials.gov study NCT00266513. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Computerized Cognitive Rehabilitation of Patients With Cognitive Deficits Due to the Human Immunodeficiency Virus
ClinicalTrials.gov study NCT06603727. IPD Sharing: NO. Countries: 1. Publications: 23.
The Effect of Antacids on the Pharmacokinetics (PK) of Raltegravir in Human Immunodeficiency Virus (HIV)-Infected Participants (MK-0518-824)
ClinicalTrials.gov study NCT02473367. IPD Sharing: YES. Countries: 0. Publications: 1.
Phase I Protocol for the Evaluation of the Safety and Immunogenicity of Vaccination With Synthetic HIV Envelope Peptides in Patients With Early Human Immunodeficiency Virus Infection
ClinicalTrials.gov study NCT00001386. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders
ClinicalTrials.gov study NCT00895271. IPD Sharing: NO. Countries: 1. Publications: 2.
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OpenNeuro
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