Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
8,060
datasets available to search
ShareScore release 0.7.1
Dataset results
8,060 results for “injury”
2D Electrial Impedance Tomography - Porcine model of Acute Lung Injury - PEEP trial
<p>This is an Electrical Impedance Tomography (EIT) dataset of a porcine model of acute lung injury (ALI), performing positive end-expiratory pressure (PEEP) trials in order to find 'optimal' PEEP.</p> <p>The data constist of 8 pigs with 2 measurements each, once before ALI and once after ALI induciton.</p> <p>Data is present as the *.bin format exported from Dräger Pulmovista V500 software. It can be read and analysed using the ALIVE eitprocessing software. </p>
Extreme heat and heatwaves are linked to the risk of unintentional child injuries in Guangzhou city
<p>This repository holds source data for the manuscript figures, which are available as Excel files.</p>
Data from: Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
<p><span>Cognitive impairments are a common consequence of traumatic brain injury (TBI). The hippocampus is a subcortical structure that plays a key role in the formation of declarative memories and is highly vulnerable to TBI. The α7 nicotinic acetylcholine receptor (nAChR) is highly expressed in the hippocampus and reduced expression and function of this receptor are linked with cognitive impairments in Alzheimer's disease and schizophrenia. Positive allosteric modulation of α7 nAChRs with AVL-3288 enhances receptor currents and improves cognitive functioning in naïve animals and healthy human subjects. Therefore, we hypothesized that targeting the α7 nAChR with the positive allosteric modulator AVL-3288 would enhance cognitive functioning in the chronic recovery period of TBI. To test this hypothesis, adult male Sprague Dawley rats received moderate parasagittal fluid-percussion brain injury or sham surgery. At 3 months after recovery, animals were treated with vehicle or AVL-3288 at 30 min prior to cue and contextual fear conditioning and the water maze task. Treatment of TBI animals with AVL-3288 rescued learning and memory deficits in water maze retention and working memory. AVL-3288 treatment also improved cue and contextual fear memory when tested at 24 hr and 1 month after training, when TBI animals were treated acutely just during fear conditioning at 3 months post-TBI. Hippocampal atrophy but not cortical atrophy was reduced with AVL-3288 treatment in the chronic recovery phase of TBI. AVL-3288 application to acute hippocampal slices from animals at 3 months after TBI rescued basal synaptic transmission deficits and long-term potentiation (LTP) in area CA1. Our results demonstrate that AVL-3288 improves hippocampal synaptic plasticity, and learning and memory performance after TBI in the chronic recovery period. Enhancing cholinergic transmission through positive allosteric modulation of the α7 nAChR may be a novel therapeutic to improve cognition after TBI.</span></p>
A novel use of virtual reality in the treatment of cognitive and motor deficit in spinal cord injury
<p>Aim of this study is to evaluate the cognitive and motor outcomes after a combined rehabilitative training using a standard cognitive approach and virtual reality (VR), in a patient with spinal cord injury (SCI). A 60-year-old right-handed man, affected by incomplete cervical SCI, came to our observation for a moderate tetraparesis, mainly involving the left side, after about 6-months from the acute event. The neurological examination showed imbalance with upper limb incoordination, besides the paresis mainly involving the left side. At a neuropsychological evaluation, he presented important impairment in cognitive and behavioural status, with temporal and spatial disorientation, a reduction of attention and memory process, deficit of executive function and a severe depression of mood, which was not detected during the previous recovery. Motor and cognitive deficits in SCI. The patient was 1st submitted to standard cognitive training and traditional physiotherapy, and then to a combined therapeutic approach, in which virtual reality training was provided by means of the virtual reality rehabilitation system (VRRS, Khymeia, Italy). After the combined therapeutic approach with the VRRS training, we observed a significant improvement in different cognitive domains, a notable reduction of anxiety and depressive symptoms, as well as motor performance, and balance improvement. Virtual reality can be considered a promising tool for the rehabilitation of different neurological disorders, including patients with both motor and cognitive deficits following SCI.</p>
Dataset related to article "Systematic review and meta-analysis of preclinical studies testing mesenchymal stromal cells for traumatic brain injury"
<p>Mesenchymal stromal cells (MSCs) are widely used in preclinical models of traumatic brain injury (TBI). Results are promising in terms of neurological improvement but are hampered by wide variability in treatment responses. We made a systematic review and meta-analysis: 1) to assess the quality of evidence for MSC treatment in TBI rodent models; 2) to determine the effect size of MSCs on sensorimotor function, cognitive function and anatomical damage; 3) to identify MSC-related and protocol-related variables associated with greater efficacy; 4) to understand whether MSC manipulations boost therapeutic efficacy.</p> <p>The meta-analysis included 80 studies. After TBI, MSCs improved sensorimotor and cognitive deficits, and reduced anatomical damage. Stratified meta-analysis on sensorimotor outcome showed similar efficacy for different MSC sources and for syngeneic or xenogenic transplants. Efficacy was greater when MSCs were delivered in the first week post-injury, and when implanted directly into the lesion cavity. The greatest effect size was for cells embedded in matrices or for MSC-derivatives.</p> <p>MSC therapy is effective in preclinical TBI models, improving sensorimotor, cognitive and anatomical outcomes, with large effect sizes. These findings support clinical studies in TBI.</p> <p>The present dataset reports extrapolated data used for the meta-analysis</p>
Data from: Molecular and cellular processes of deafferentation after plexus injury in human dorsal root ganglia
<p><strong>Dataset of human dorsal root ganglia (DRG) images and deep learning models</strong></p> <p>Sections of six control and six plexus patient DRG were immunostained and imaged using large-field (tile) microscopy. Two staining combinations were investigated: </p> <p>- n<em>eurofilament </em>(NF), <em>fatty acid binding protein 7</em> (FABP7), and <em>clusterin (</em>APOJ)</p> <p>- n<em>eurofilament </em>(NF),<em> ionized calcium-binding adapter molecule 1 (</em>IBA1), and <em>microtubule-associated protein 2</em> (MAP2) </p> <p>NF-positive neurons were segmented with a deep learning method (<em>deepflash2</em>). FABP7 and IBA1 were segmented with a thresholding method.</p> <p>Provided are:</p> <p>- all images and corresponding segmentation masks for NF, FABP7, and IBA1 </p> <p>- images and annotated segmentation masks of NF-positive neurons (3 experts annotated the same 10 images, the estimated ground truth masks were used for training of deep learning models)</p> <p>- the deep learning model ensemble (3) for segmentation of NF-positive neurons</p> <p> </p> <p> </p>
Effects of ACTH4-10Pro8-Gly9-Pro10 on anti-inflammatory cytokine (IL-4, IL-10, IL-13) expression in acute spinal cord injury model (Sprague Dawley rats)
<p class="MsoNormal"><span><strong>Background:</strong> Spinal cord injury (SCI) is a destructive neurological and pathological state that causes major motor, sensory and autonomic dysfunctions. It's final neurological outcome determined from both primary and secondary injury process. Neuroinflammation is a key component of the secondary injury mechanisms with local and systemic consequences. </span>A neuroprotective compound, ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup>also known as Semax has <span>shown neuroprotective and anti-inflammatory properties. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> <span>also has actively used in the treatment of brain ischemia without serious complication reported. Here we analyzed the effects of </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> in regulating inflammatory cascade in SCI by looking at the expression of anti-inflammatory cytokine IL-4, IL-10, IL-13 in acute compression SCI.</p> <p><span><strong>Method: </strong>We do laminectomy in Sprague Dawley rats at the second thoracic vertebrae. After laminectomy we expose the myelum and create mild SCI model with 20gr and severe SCI with 35gr aneurysm clips. </span>ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10 </sup><span>was administered intranasally to the treatment group and 0,9% NaCl to the control group (placebo). Both group was remain alive and terminated at 3 and 6 hour. </span>The preparations tissue sample were fixed in formalin and examined for immunohistochemistry<span>. Quantitative measurement of anti-inflammatory cytokine (</span>IL-4, IL-10, IL-13) was done in posterior horn with associated anti-monoclonal antibodies.</p> <p> </p> <p><strong>Result:</strong> Rats with mild SCI that were given ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> shown greater expression of IL-4, IL-10 and IL-13 at three hour post compression but only IL-10 and IL-13 elevated significantly at six hour. Rats with severe compression in ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> group shown greater expression of IL-10, IL-13 at three hour and IL-4, IL-10 at six hour compared with the placebo group.</p> <p> </p> <p><strong>Conclusion: </strong>Administration of ACTH<sub>4-10</sub>Pro<sup>8</sup>-Gly<sup>9</sup>-Pro<sup>10</sup> intranasal can increase anti inflammatory cytokine expression at Sprague Dawley rat model with mild and severe SCI. Expression of anti inflammatory cytokine was greater in mild compression and early hour (3 hour). Further research needs to be done to determine optimal dose and the actual clinical outcome in vivo.</p>
Automated, medication-targeted alerts for Acute Kidney Injury – A randomized trial
<p>Acute kidney injury is common among hospitalized individuals, particularly those exposed to certain medications, and is associated with substantial morbidity and mortality. In a pragmatic, open-label, parallel group randomized controlled trial (clinicaltrials.gov NCT02771977), we investigate whether an automated clinical decision support system affects discontinuation rates of potentially nephrotoxic medications and improves outcomes in patients with AKI. Participants included 5,060 hospitalized adults with AKI and an active order for any of three classes of medications of interest: non-steroidal anti-inflammatory drugs, renin-angiotensin-aldosterone system inhibitors, or proton pump inhibitors. Within 24 hours of randomization, a medication of interest was discontinued in 61.1% of the alert group versus 55.9% of the usual care group (relative risk 1.08, 1.04–1.14, p=0.0003). The primary outcome – a composite of progression of acute kidney injury, dialysis, or death – occurred in 585 (23.1%) individuals in the alert group and 639 (25.3%) patients in the usual care group (RR 0.92, 0.83–1.01, p=0.09). The pre-specified subgroup analysis found a significant benefit of alerting among those exposed to proton pump inhibitors but not non-steroidal anti-inflammatory drug or renin-angiotensin system inhibitor.</p>
Data from: Internal injuries in marine fishes caught in beam trawls using electrical versus mechanical stimulations
<p><span>To improve the ecological and economic sustainability in the Dutch beam trawl fishery, tickler chains were replaced by electrical pulse stimulation to drive sole (<em>Solea</em> <em>solea</em>) out of the seabed. Because electrical stimulation may cause internal injuries, we quantified this risk by sampling fish species from commercial beam trawlers and recording spinal injuries and haemorrhages from X-radiographs and autopsy. To distinguish mechanically and electrical-pulse-induced injuries, we compared injuries in ten species sampled from pulse (PUL) and tickler-chain (TCK) trawlers and four species sampled from PUL trawlers with the stimulus switched on or off. Co-occurrence of a major spinal injury and major haemorrhage at the same location was only observed in PUL samples, and were frequently (40%) observed in cod (<em>Gadus</em> <em>morhua</em>) and in low numbers (0–2%) in whiting (</span><span><em>Merlangius</em> <em>merlangus</em>)</span><span>, grey gurnard (<em>Eutrigla</em> <em>gurnardus</em>), and greater sandeel </span><span>(<em>Hyperoplus</em> <em>lanceolatus</em>),</span><span> but not in flatfishes and other species. In cod, injury occurrence correlated with fish length, with lower probabilities for small fish. Major spinal injury or major haemorrhage occurrence in PUL (range: <1–16%) was lower than in TCK (range: <1–42%) in eight of the ten species studied. Population-level consequences of pulse-induced injuries are considered negligible.</span></p>
PASS - A SCORING SYSTEM TO EVALUATE PERSISTENT ACUTE KIDNEY INJURY IN CRITICALLY ILL ADULT ICU PATIENTS
<p>Acute Kidney Injury (AKI) and sepsis is highly prevalent in Intensive Care Units (ICU) and has direct effect on mortality and morbidity. We aimed to evaluate if course and recovery of sepsis-AKI can be predicted using variables collected at the time of admission, and to develop a formula - Persistent AKI Scoring System (PASS) to predict recovery.</p> <p>63 consecutive patients admitted for sepsis-AKI in our ICUs were evaluated over a period of 8 months. Baseline demographic and clinical/laboratory parameters ,including serum creatinine (SCr), Base Excess (BE), Plethysmographic Variability Index (PVI), Caval Index, R wave Variability (RVI), Mean Arterial Pressure (MAP) and Renal Resistivity Index (RI) using renal doppler and need for inotropes were assessed on admission. Patients were managed with standard protocols with fluid resuscitation and other specific therapy. After 6 of hours of fluid resuscitation, hemodynamic status and volume status of the patient was assessed. Patients were classified as Volume Responders or Non-responders depending on hemodynamic stabilization using parameters like MAP. Re- assessment of all the variables was done at 24 hours and 72 hours after admission. The primary outcome was persistent AKI after 72hrs. The secondary outcome was initiation of dialysis and death within 15 days of admission.</p> <p>34 subjects recovered from AKI. 32 patients showed volume response with respect to hemodynamic parameters and 31 patients were non-responders. Response to fluid, MAP at admission, MAP after 6 hours, BE at admission, inotrope requirement, and PVI at admission did not correlate with recovery of AKI. RI, RVI and S Cr at admission significantly correlated with recovery from AKI These 3 parameters were evaluated further to develop the model for predicting recovery from AKI.• Score> 7.8 predicted recovery from AKI with sensitivity of 79.4%, specificity of 72.4%. PPV 81.8% and NPV 76.7%. PASS Score>7.8 had AUROC of 0.85.</p> <p>Multiple logistic regression showed that SCr< 2.36 mg%, RVI > 14.45 and RI < 0.8 on admission correlated with recovery.</p> <p>PASS SCORE Formula was created using the same.</p> <p>CONCLUSION: PASS score can be a simple bed side method to reliably identify salvageable cases of sepsis-AKI, guiding fluid resuscitation and also aiding early referrals from rural to higher centers for better management.</p>
Intrinsic TGF-b Signaling Attenuates Proximal Tubule Mitochondrial Injury and Inflammation in Chronic Kidney Disease
<p>Bulk RNA sequencing processed count files for the article titled "Intrinsic TGF-b Signaling Attenuates Proximal Tubule Mitochondrial Injury and Inflammation in Chronic Kidney Disease", by Nlandu Khodo et al., in review. </p> <p>Corresponding GEO submission can be found here: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225545 </p>
Supporting data and analysis for," A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease", main figures PART 1
<p>This deposit contains the supporting records of images and image analysis presented in, " A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease". doi: https://doi.org/10.1101/2022.06.22.497218</p> <p>Associated Zenodo repositories:</p> <table> <thead> <tr> <th scope="col">Description</th> <th scope="col">DOI</th> </tr> </thead> <tbody> <tr> <td>Main figures PART 1, Figure 1,2,3,5</td> <td>10.5281/zenodo.7653239</td> </tr> <tr> <td>Main figures PART 2, Figure 6</td> <td>10.5281/zenodo.7900973</td> </tr> <tr> <td>Supplemental 3DTC figures: S1, S4, S5, S7, S8, S9</td> <td>10.5281/zenodo.7894632</td> </tr> </tbody> </table> <p>Contents:1) a collection of .zip files contains the 3D tissue cytometry files for tissue analyzed in the manuscript doi: https://doi.org/10.1101/2022.06.22.497218. This collection includes the individual analyses for figures 2, 3 and 5. Figure 6 analyses are included in a compansion repository: 10.5281/zenodo.7900973. Contents of zip files by figure contain at a minimum the .obx and a .tif file which includes the segmented objects and associated measurements for use by VTEA (https://vtea.wiki/). Additional files may include gate files (.vtg) or max projections (.tif).</p> <p>2) a collection of zip files containing the RNAScope image files shown in: Figure 1 P,Q. The supplemental figure data for RNAScope. Figures S1,S4 and S5 are found in: 10.5281/zenodo.7894633.</p> <p>Please address any concerns or questions to the authors listed in the deposit or manuscript, doi: https://doi.org/10.1101/2022.06.22.497218</p>
Supporting data and analysis for," A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease", Supplemental 3DTC figures
<p>This deposit contains the supporting records of analysis for 3D cytometry presented in, " A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease". doi: https://doi.org/10.1101/2022.06.22.497218 found in supplemental figures.</p> <p>Contents:</p> <p>1) a collection of .zip files contains the 3D tissue cytometry files for tissue analyzed in the manuscript doi: https://doi.org/10.1101/2022.06.22.497218. This collection includes the individual analyses by figures in the supplemental figure data for 3D tissue cytometry. The main figure data is found at: 10.5281/zenodo.7653239 and 10.5281/zenodo.7900973.</p> <p>2) a collection of zip files containing the RNAScope image files shown in: Figures S1,S4 and S5. The main RNAScope figure data is found at: 10.5281/zenodo.7653239</p> <p>Please address any concerns or questions to the authors listed in the deposit or manuscript, doi: https://doi.org/10.1101/2022.06.22.497218</p>
Supporting data and analysis for," A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease", main figures PART 2
<p>This deposit contains the supporting records of analysis for 3D cytometry presented in, " A spatially anchored transcriptomic atlas of the human kidney papilla identifies significant immune injury in patients with stone disease". doi: https://doi.org/10.1101/2022.06.22.497218</p> <p>Contents:</p> <p>1) a collection of .zip files contains the 3D tissue cytometry files for tissue analyzed in the manuscript doi: https://doi.org/10.1101/2022.06.22.497218. This collection includes the individual analyses for figure 6 analyses.</p> <p>Contents of zip files by figure contain at a minimum the .obx and a .tif file which includes the segmented objects and associated measurements for use by VTEA (https://vtea.wiki/). Additional files may include gate files (.vtg) or max projections (.tif).</p> <p> </p> <p>Please address any concerns or questions to the authors listed in the deposit or manuscript, doi: https://doi.org/10.1101/2022.06.22.497218</p> <p> </p>
PASS: A scoring system to evaluate persistent kidney injury in critically ill ICU adult patients
<p>Acute Kidney Injury (AKI) and sepsis is highly prevalent in Intensive Care Units (ICU) and has direct effect on mortality and morbidity. We aimed to evaluate if course and recovery of sepsis-AKI can be predicted using variables collected at the time of admission, and to develop a formula - Persistent AKI Scoring System (PASS) to predict recovery.</p> <p>63 consecutive patients admitted for sepsis-AKI in our ICUs were evaluated over a period of 8 months. Baseline demographic and clinical/laboratory parameters ,including serum creatinine (SCr), Base Excess (BE), Plethysmographic Variability Index (PVI), Caval Index, R wave Variability (RVI), Mean Arterial Pressure (MAP) and Renal Resistivity Index (RI) using renal doppler and need for inotropes were assessed on admission. Patients were managed with standard protocols with fluid resuscitation and other specific therapy. After 6 of hours of fluid resuscitation, hemodynamic status and volume status of the patient was assessed. Patients were classified as Volume Responders or Non-responders depending on hemodynamic stabilization using parameters like MAP. Re- assessment of all the variables was done at 24 hours and 72 hours after admission. The primary outcome was persistent AKI after 72hrs. The secondary outcome was initiation of dialysis and death within 15 days of admission.</p> <p>34 subjects recovered from AKI. 32 patients showed volume response with respect to hemodynamic parameters and 31 patients were non-responders. Response to fluid, MAP at admission, MAP after 6 hours, BE at admission, inotrope requirement, and PVI at admission did not correlate with recovery of AKI. RI, RVI and S Cr at admission significantly correlated with recovery from AKI These 3 parameters were evaluated further to develop the model for predicting recovery from AKI.• Score> 7.8 predicted recovery from AKI with sensitivity of 79.4%, specificity of 72.4%. PPV 81.8% and NPV 76.7%. PASS Score>7.8 had AUROC of 0.85.</p> <p>Multiple logistic regression showed that SCr< 2.36 mg%, RVI > 14.45 and RI < 0.8 on admission correlated with recovery.</p> <p>PASS SCORE Formula was created using the same.</p> <p>CONCLUSION: PASS score can be a simple bed side method to reliably identify salvageable cases of sepsis-AKI, guiding fluid resuscitation and also aiding early referrals from rural to higher centers for better management.</p>
Outcome analysis of Posterior Cruciate Ligament injuries
<p><strong>Background - </strong>The posterior cruciate ligament (PCL), a major stabiliser of the knee, restrains the posterior translation of tibia over femur. Injury to the two bundles of this ligament is usually seen in a motor vehicle accident, followed by dashboard injury.</p> <p><strong>Methods - </strong>Non-operative management post posterior cruciate ligament tears includes non-steroidal anti-inflammatory drugs and rehabilitation. Common surgical procedures include trans-tibial tunnel or tibial inlay technique of graft reconstruction, single bundle or double bundle reconstruction. Literature on outcomes of posterior cruciate ligament injuries managed with either of the methods is sparse; we therefore aim to conduct an interventional study to analyse the patients’ functional status and satisfaction post treatment.</p> <p><strong>Conclusions -</strong> Lysholm knee scoring scale and IKDC knee scoring system will be used as outcome measures. The follow up scores are taken six, 12, 15 and 24 months after the treatment.</p>
Imaging dataset from: Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron
<div> <span><span>Acute kidney injury (AKI) is a risk factor for chronic kidney disease (CKD), but the cellular mechanisms leading to i</span><span>m</span><span>paired tubular recovery and </span><span>subsequent</span> <span>AKI-CKD-transition are not yet fully understood. In this study, we combined </span><span>transgenic mice to </span><span>monitor</span><span> proliferation in vivo, </span><span>a novel </span><span>injury </span><span>model of AKI, in which </span><span>ischemia</span></span><span><span>-</span></span><span><span>reperfusion injury </span><span>(IRI) was induced in half of the kidney (partial</span></span><span><span>-</span></span><span><span>IRI), and serial intravital 2-photon imaging via an </span><span>Abdominal I</span><span>maging </span><span>W</span><span>indow (AIW) to track tissue remodeling in post- and non-ischemic kidney regions longitudinally over 3 weeks. Our results and novel findings are presented in the associated pre-print "Longitudinal tracking of acute kidney injury reveals injury propagation along the nephron".</span></span><span> </span> </div> <div> <span><span>In this dataset, we </span><span>provide</span><span> the imaging data which we </span><span>acquired</span><span> during the study.</span><span> Overall, the dataset consists of: #1: serial intravital imaging via 2-photon microscopy and genetic identification of proliferating cells in kidneys undergoing partial IRI; #2: serial intravital imaging via 2-photon microscopy and genetic identification of proliferating cells of control, uninjured kidneys; #3: intravital imaging of kidney epithelial cells during intravenous injection of a fluorescent bolus to determine the identity of tubular segments across the nephron; #4: intravital imaging of </span><span>and genetic identification of proliferating cells </span><span>after selective laser injury of </span><span>S1 </span><span>proximal tubule cells; #5 in vivo and ex-vivo imaging of kidney and kidney slices after VCAM1 staining. The data descriptors </span><span>provide</span><span> detailed guidelines on how to place individual imaging files in the context of the pathophysiological states used in the study.</span></span><span> </span> </div> <div> <span><span>Our goal is to </span><span>provide</span><span> an organize</span><span>d</span> <span>and accessible </span><span>unique and unprocessed </span><span>in vivo imaging dataset </span><span>that </span><span>documents </span></span><span><span>in vivo</span></span><span><span> tubule cell remodeling in </span><span>the mouse kidney </span></span><span><span>longitudinally and</span></span> <span><span>during </span><span>physiological and pathological conditions. Sharing </span><span>of </span><span>th</span><span>is</span><span> dataset </span><span>ensures</span><span> </span><span>reproducing</span><span> and expanding </span><span>of </span><span>our preclinical findings of </span><span>tubule injury and (failed)</span><span> recovery during AKI</span><span>. Furthermore, this dataset may also be </span><span>utilized</span> <span>for teaching purposes, as the combination of fluorescent imaging techniques allow</span><span>s</span><span> the </span><span>detail</span><span>ed</span><span> visualization of</span><span> kidney anatomy and physiology over multiple conditions.</span></span> </div>
Code and data for "Postreproductive female killer whales reduce socially inflicted injuries in their male offspring"
<p>R code and data necessary to reproduce all analyses from the manuscript "Postreproductive female killer whales reduce socially inflicted injuries in their male offspring". Included is demographic and social data on 103 southern resident killer whales, the R code to fit Bayesian regression models and code to produce the plots in the manuscript.</p>
Antimicrobial peptides modulate lung injury by altering the intestinal microbiota
<p>This repository contains the OTU tables for "Antimicrobial peptides modulate pulmonary inflammation by altering the intestinal microbiota" by Abdelgawad and Nicola et al., an analysis of the role of antimicrobial peptide in the gut-lung axis during hyperoxia-induced lung injury. This work was supported by the National Heart, Lung, and Blood Institute of the U.S. National Institutes of Health, K NIH: K08 HL151907 (KW), K08 HL141652 (CL), K08 DK120871 (AO); the Kaul Pediatric Research Institute at Children’s of Alabama (KW), and the Microbiome Center at UAB (KW). The funding agencies had no role in the design, conduct, and analysis of the study or in the decision to submit the manuscript for publication. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. All data in this repository is the intellectual property of the authors and may be utilized for academic publication only with prior written permission.</p>
Data from: Costs of social conflict: do injuries mirror patterns of aggression in blue monkeys?
<p class="MsoNormal">In wild animals, injuries often arise from intraspecific contests, and therefore may reveal challenges and selection pressures related to social conflict. We evaluated whether known aggressive patterns predicted injury patterns in wild blue monkeys, in which most injuries of known cause resulted from conspecifics. After describing injuries and their causes in 12 groups monitored over 13 years, we compared injury distributions across age-sex class and season. Adult males were much more likely, adult females about equally likely, and immatures much less likely to sustain injuries relative to random expectation. Among adult males, injuries were most common in the mating season. Using multivariate models, we examined how individual, social, and demographic factors predicted injury rates in adult females and immatures. Rates were higher for adult females versus all immatures, for individuals in smaller groups, and for those living in groups frequently exposed to novel adult males and with few immature members. Among older juvenile and adult females, these trends persisted; additionally, pregnant and lactating females were injured less often than others, but there was no evidence that dominance rank influenced injury rates. For juveniles, injury rates increased similarly with age in both sexes, providing only limited evidence that heightened aggression motivates natal dispersal by males. Most findings supported the hypothesis that aggression increases injury risk. Costs of within-group aggressive competition may manifest in ways other than injury, however, especially for females. We highlight the importance in comparative analyses of considering both within- and between-group aggression and demographic variables as influencing injury risk. <span> </span></p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.