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389 results for “lifetime”
Reliable and remote monitoring of absolute temperature during liver inflammation via luminescence lifetime-based nanothermometry
<p>Dataset of https://zenodo.org/record/5793930#.YcCqyGjMJPY</p>
Patterns of Testosterone in Male White-tailed Deer (Odocoileus virginianus): Seasonal and Lifetime Variation
<p>Testosterone is strongly associated with the annual development of antlers in cervids, but. endocrine research on wild, freely breeding ungulates is often done without repeated capture of known-aged individuals. As a result, our knowledge on how testosterone fluctuates over the course of a lifetime and variation in lifetime patterns among individuals is limited. We investigated patterns of testosterone in a freely breeding population of white-tailed deer (<i>Odocoileus virginianus</i>) in Alabama, USA that breeds in January. Testosterone peaked during the height of the breeding season, despite this period occurring approximately two months later than in most temperate-region, white-tailed deer populations. Age-related differences in testosterone were only prevalent during the breeding season, with bucks ≥3.5 years old having greater testosterone (853 ng/dl ±96 SE; <i>P</i> = 0.012) than bucks 1.5–2.5 years old (364 ng/dl ±100 SE). Additionally, an individual's testosterone level as a yearling was not positively associated with their lifetime maximum testosterone level (<i>P</i> = 0.583), and an individual's mean testosterone level was positively associated with lifetime testosterone variation (<i>P</i> < 0.001). To our knowledge our study is one of the first to assess how testosterone early in life might relate to individual testosterone later in life. We believe these data provide insight into lifetime hormonal patterns in cervids, and that these patterns may indicate intraspecific variation of lifetime reproductive strategies.</p>
Wind turbines without curtailment produce large numbers of bat fatalities throughout their lifetime: A call against ignorance and neglect
<p>Bats are protected by national and international legislation in European countries, yet many species, particularly migratory aerial insectivores, collide with wind turbines which counteracts conservation efforts. Within the European Union it is legally required<br> to curtail the operation of wind turbines at periods of high bat activity, yet this is not practiced at old wind turbines. Based on data from the national carcass repository in Germany and from our own carcass searches at a wind park with three turbines west<br> of Berlin, we evaluated the magnitude of bat casualties at old, potentially mal-sited wind turbines operating without curtailment. We report 88 documented bat carcasses collected by various searchers over the 20-year operation period of this wind park from<br> 2001 to 2021. Common noctule bats ( Nyctalus noctula ) and common pipistrelles (Pipistrellus pipistrellus ) were most often found dead at these turbines. Our search campaign in August and September 2021 yielded a total of 18 carcasses. We estimated that at least 209 bats were likely killed during our field survey, yielding more than 70 casualties/wind turbine or 39 casualties/MW in two months. Since our campaign covered only part of the migration season, we consider this value as an underestimate. The 20-year period of the wind park emphasises the substantial impact old turbines may have on bat individuals and populations when operating without curtailments. We call for reconsidering the operation procedures of old wind turbines to stop the continuous loss of bats in Germany and other countries where turbine curtailments are even less practiced than in Germany.</p>
Lifetime reproductive output and life-history traits of lizards
<p><span><span><span><span><span><span><span><span><span><span><span><span><b>Aim: </b>Latitudinal gradients in life-history traits are apparent in many taxa and are expected to be strong for ectotherms that have temperature-driven constraints on performance and fitness. The strength of these gradients, however, should also be affected by diet. Because diet type (carnivory, omnivory, herbivory) influences accessibility to nutrition and assimilation efficiency, we aim to study how diet affects latitudinal gradients in lifetime reproductive output and the underlying life-history traits in ectotherms.</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Location: </b>Global.</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Time period: </b>Recent.</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Major taxa studied: </b>Lizards (Reptilia, Squamata, Sauria).</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Methods: </b>We used empirical (352 species) and phylogenetically imputed data (563 species) to analyse the interactive effects of latitude and diet on life-history traits (longevity, age at maturity, reproductive lifespan, hatchling mass, clutch/brood size, clutch/brood frequency, female mass) and lifetime reproductive output of lizards.</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Results: </b>Lifetime reproductive output does not significantly differ in lizards across diet types, and only carnivores exhibit a small increase at higher latitudes. Diet type, however, influences latitudinal patterns of individual life-history traits. Carnivores exhibit a shift towards "slower-paced" life-histories at higher latitudes for most traits (increased longevity, age at maturity, reproductive lifespan, and decreased clutch frequency). By contrast, herbivores either display "faster-paced" life-histories (reduction in reproductive lifespan, hatchling mass, female mass) or no change (clutch frequency, clutch size, age at maturity) at higher latitudes. Omnivores exhibit intermediate and muted latitudinal patterns.</span></span></span></span></span></span></span></span></span></span></span></span></p> <p><span><span><span><span><span><span><span><span><span><span><span><span><b>Main conclusions: </b>We suggest that the nutritional challenges of herbivory, compounded by thermal constraints at higher latitudes, may explain differences in life-history characteristics of herbivorous ectotherms. Intermediate patterns exhibited by omnivores highlight how flexibility in diet can buffer environmental challenges at higher latitudes. Our results indicate that lizards with different diet types display various trends in their life-histories across latitudes, which eventually balance out to result in similar reproductive outputs throughout their lifetime, with little benefits to carnivory.</span></span></span></span></span></span></span></span></span></span></span></span></p>
St. Jude Lifetime Study Cohort dataset for multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer
<p>The dataset contains variables from the St. Jude Lifetime Cohort Study used in the study of multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer in Horan et al., 2024 (DOI:<a href="https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2818384" target="_blank" rel="noopener">10.1001/jamanetworkopen.2024.10145</a>). </p> <p><strong>When using downloaded data, please cite corresponding paper and this repository:</strong></p> <ol> <li>Horan MR, Srivastava DK, Choi J, et al. Multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer. <em>JAMA Netw Open.</em> 2024;7(5):e2410145. doi:10.1001/jamanetworkopen.2024.10145</li> <li>Horan MR, Srivastava DK, Choi J, et al. (2018). St. Jude Lifetime Study Cohort Dataset for multilevel characteristics of cumulative symptom burden in young survivors of childhood cancer (Version 1) [Data set]. 2024. Zenodo. http://doi.org/10.5281/zenodo.11474180</li> </ol> <p><strong>Funding:</strong></p> <p>The research reported in the manuscript was supported by the US National Cancer Institute under award numbers U01CA195547, R01CA238368, T32CA225590, and P30CA021765. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies.</p>
Dataset: Phytoplankton Cell-States: multiparameter lifetime flow monitoring reveals cellular heterogeneity: additional repeats
<p>Additional datasets of repeated experiments for Dataset: Phytoplankton Cell-States: multiparameter lifetime flow monitoring reveals cellular heterogeneity</p>
Short lifetime components in the relaxation of boron acceptors in silicon
<p>The data is that described in 'Short lifetime components in the relaxation of boron acceptors in silicon’, K. Saeedi et al, Physical Review B (2018).</p> <p>The data consists of the probe transmission as a function of time delay in each case. The different experiments are labelled according to the figure in which they occur in the main paper. The data are raw and have not been smoothed or otherwise processed.</p> <p>The data is in an Origin file format. Please contact the author for data in other formats.</p>
Raw Data for "Combining experiments and relativistic theory for establishing accurate radiative quantities in atoms: the lifetime of the $^2$P$_{3/2}$ state in $^{40}$Ca$^+$"
<p>Raw data and analysis files (Matlab) for the paper: "Combining experiments and relativistic theory for establishing accurate radiative quantities in atoms: the lifetime of the $^2$P$_{3/2}$ state in $^{40}$Ca$^+$".</p>
Ageing as early-life inertia: disentangling life-history trade-offs along a lifetime of an individual
<p>The theory that ageing evolves because of competitive resource allocation between the soma and the germline has been challenged by studies showing that somatic maintenance can be improved without impairing reproduction. However, it has been suggested that cost-free improvement in somatic maintenance is possible only under a narrow range of benign conditions. Here we show that experimental downregulation of insulin/IGF-1 signalling (IIS) in C. elegans nematodes, a robustly reproducible lifespan and healthspan-extending treatment, reduces fitness in a complex variable environment when initiated during development but does not reduce fitness when initiated in adulthood. Thus, our results show that the costs and benefits of reduced IIS can be uncoupled when organisms inhabit variable environments, and, therefore, do not provide support for the resource allocation theory. Our findings support the theory that the force of natural selection on gene expression in evolutionarily conserved signalling pathways that shape life-history traits declines after the onset of reproduction resulting in organismal senescence.</p>
Silicon-29 NMR Experimental Datasets from Silicon-29 Echo Train Coherence Lifetimes and Geminal J-Couplings in Network Modified Silicate Glasses
<p>Silicon-29 Phase-Incremented Echo-Train Acquisition Nuclear Magnetic Resonance datasets that are analyzed to obtain the data in the figures of the paper "Silicon-29 Echo Train Coherence Lifetimes and Geminal <sup>2</sup>J-Couplings in Network Modified Silicate Glasses." </p> <p>Details of the csdf dataset format are given in <a href="https://doi.org/10.1371/journal.pone.0225953"><em>PLOS ONE,</em> 15(1): e0225953 (2020)</a>, "Core Scientific Dataset Model: A lightweight and portable model and file format for multi-dimensional scientific data," D. Srivastava, T. Vosegaard, D. Massiot, and P.J. Grandinetti. The data within csdf files can be accessed with the Python package <a href="https://csdmpy.readthedocs.io/en/stable">csdmpy</a>, or other CSDM-compliant software.</p>
Simultaneous NAD(P)H and FAD fluorescence lifetime microscopy of long UVA–induced metabolic stress in reconstructed human skin
<p>Solar ultraviolet longwave UVA1 exposure of human skin has short-term consequences at cellular and molecular level, leading at long-term to photoaging. Following exposure, reactive oxygen species (ROS) are generated, inducing oxidative stress that might impair cellular metabolic activity. However, the dynamic of UVA1 impact on cellular metabolism remains unknown because of lacking adequate live imaging techniques. Here we assess the UVA1-induced metabolic stress response in reconstructed human skin with multicolor two-photon fluorescence lifetime microscopy (FLIM). Simultaneous imaging of nicotinamide adenine dinucleotide (NAD(P)H) and flavin adenine dinucleotide (FAD) by wavelength mixing allows quantifying cellular metabolism in function of NAD(P)+/NAD(P)H and FAD/FADH2 redox ratios. After UVA1 exposure, we observe an increase of fraction of bound NAD(P)H and decrease of fraction of bound FAD indicating a metabolic switch from glycolysis to oxidative phosphorylation or oxidative stress possibly correlated to ROS generation. NAD(P)H and FAD biomarkers have unique temporal dynamic and sensitivity to skin cell types and UVA1 dose. While the FAD biomarker is UVA1 dose-dependent in keratinocytes, the NAD(P)H biomarker shows no dose dependence in keratinocytes, but is directly affected after exposure in fibroblasts, thus reflecting different skin cells sensitivities to oxidative stress. Finally, we show that a sunscreen including a UVA1 filter prevents UVA1 metabolic stress response from occurring.</p>
FIG. 3 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 3.—Age at first reproduction for female Timber Rattlesnakes (Crotalus horridus) at two focal dens in northeastern New York, USA. Den F (n ¼ 28), Den B (n ¼ 44).
FIG. 1 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 1.—Map of den sites for a metapopulation of Timber Rattlesnakes (Crotalus horridus) in northeastern New York, USA. Data from two dens (F, B) were the basis for reporting comparative reproductive variables.
FIG. 8 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 8.—Lifetime reproductive efforts of female Timber Rattlesnakes (Crotalus horridus) at two focal dens based on 432 gravid records in 253 individuals sampled in northeastern New York, USA.
FIG. 4 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 4.—Age at first reproduction for female Timber Rattlesnakes (Crotalus horridus) in proportion to the total number of known-aged females (n ¼ 127) for all dens sampled in northeastern New York, USA.
FIG. 10 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 10.—Body mass (g) as a function of total length (cm) in gravid female Timber Rattlesnakes (Crotalus horridus) sampled from two focal dens in northeastern New York, USA. Lines are based on least-squares regressions: filled circles and upper line depicts Den B females (n ¼ 39, r2 ¼ 0.74; Y ¼ 20.9 X 1244); open circles and lower line depicts Den F females (n ¼ 48, r2 ¼ 0.60; Y ¼ 18.0 X 1035).
FIG. 12 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 12.—Change in body mass of gravid female Timber Rattlesnakes (Crotalus horridus) (n ¼ 69) from two focal dens as a function of interval between capture of the same individual (d; upper panel) and mass at initial capture (g; lower panel). In both graphs, filled circles indicate individuals from Den B, whereas open circles indicate individuals from Den F.
FIG. 11 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 11.—Body mass (mean ± 1 SE) of gravid female Timber Rattlesnakes (Crotalus horridus) from two focal dens as a function of the sequence of their reproductive events. Sample sizes are indicated above each error bar.
FIG. 9 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 9.—Distribution of body mass at first reproduction for female Timber Rattlesnakes (Crotalus horridus) sampled from two focal dens in northeastern New York, USA.
FIG. 7 in Lifetime Reproduction in a Northern Metapopulation of Timber Rattlesnakes (Crotalus horridus)
FIG. 7.—Reproductive life span of iteroparous Timber Rattlesnakes (Crotalus horridus) from two focal dens in northeastern New York, USA. Den F (n ¼ 64); Den B (n ¼ 44).
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.