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219
datasets available to search
ShareScore release 0.9.0
Dataset results
219 results for “new drugs”
A Comparison of the Effectiveness and Safety of Topiramate and Phenytoin in Patients With New Onset Epilepsy Requiring Rapid Initiation of Antiepileptic Drug Treatment
ClinicalTrials.gov study NCT00210782. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Dataset for: Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats
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Data from: Release of 50 new, drug-like compounds and their computational target predictions for open source anti-tubercular drug discovery
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Data from: New sporopollenin-based β-cyclodextrin functionalized magnetic hybrid adsorbent for magnetic solid-phase extraction of nonsteroidal anti-inflammatory drugs from water samples.
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Specific modulation of HIV RNA splicing and upregulation of anti-inflammatory miR-124 by the new drug candidate ABX464
GEO Series GSE116073. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
MUC1-C DEPENDENCY IN DRUG RESISTANT HR+/HER2- BREAST CANCER IDENTIFIES A NEW TARGET FOR TREATMENT WITH AN ANTIBODY-DRUG CONJUGATE
GEO Series GSE272989. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
New role of ID3 in melanoma adaptive drug-resistance
GEO Series GSE104849. Homo sapiens. 28 samples. Type: Expression profiling by array.
A Human Pluripotent Stem Cell Surface N-Glycoprotein resource including New Markers, Extracellular Epitopes, and Drug Targets
GEO Series GSE55805. Homo sapiens. 12 samples. Type: Expression profiling by array.
MALNC: A new mutant NPM1/IDH2R140 and PML-RARA-associated lncRNA with impact on AML cell proliferation, maturation and drug response
GEO Series GSE299161. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
New BRD4-inhibitor quinoline compound targets a distinct latent HIV-1 reservoir for re-activation from canonical “shock” drugs
GEO Series GSE100289. Homo sapiens. 20 samples. Type: Other.
Drug repurposing unveils new combinatorial treatments to treat mutant KRAS lung cancer
GEO Series GSE161218. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
A new strategy for identifying mechanisms of drug-drug interaction using transcriptome analysis: Compound Kushen injection as a proof of principle
GEO Series GSE130359. Homo sapiens. 27 samples. Type: Expression profiling by high throughput sequencing.
Identification of MUC1-C Dependence in Drug-Resistant Advanced Prostate Cancer Uncovers a New Target for Antibody-Drug Conjugate Therapy
GEO Series GSE276890. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Identification of MUC1-C Dependence in Drug-Resistant Advanced Prostate Cancer Uncovers a New Target for Antibody-Drug Conjugate Therapy
GEO Series GSE276750. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Selective inhibitors of autophagy reveal new link between the cell cycle and autophagy and lead to discovery of novel synergistic drug combinations
GEO Series GSE206261. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Subcellular pathways shared by afflicted patients and mutant mice identify a new drug treatment for aortic aneurysm in Marfan syndrome
GEO Series GSE128101. Homo sapiens; Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing.
Transcription Factor Network Reveals New Treatments for Prostate Cancer Docetaxel Drug Resistance
GEO Series GSE149681. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Efficacy and safety evaluation of a new antidepressant drug agomelatine in the treatment of post-stroke depression: a single-center clinical study
<p><b><span>Objective: </span></b>To compare the effects of agomelatine and sertraline hydrochloride on the clinical efficacy, neurocytokine and monoamine transmitter metabolism in patients with post-stroke depression. </p> <p><b><span>Methods:</span></b> A total of 94 patients with post-stroke depression admitted to our hospital from July 2015 to September 2018 were randomly divided into a test group and a control group with 47 cases each. The experimental group was treated with agomelatine 25 mg/d orally, which was increased to 50 mg/d after 1 week, and the control group was treated with sertraline hydrochloride 50 mg/d. The two groups were treated continuously for 8 weeks. The clinical efficacy, the incidence of adverse reactions and the Hamilton Depression Scale (HAMD) before and after treatment, the National Institutes of Health Stroke Scale (NIHSS) score, BI index, and neurocytokines were compared between the two groups. Derived Neurotrophic Factor: BDNF; Nerve Growth Factor: NGF), Monoamine Transmitter Metabolism (5-Hydroxytryptamine: 5-HT; 5-Hydroxyindoleacetic acid: 5-HIAA; Norepinephrine: NE) changes.</p> <p><b><span>Results:</span></b> After treatment, the total effective rates of the experimental group and the control group were 82.97% (39 cases/47 cases) and 80.85% (38 cases and 47 cases), respectively, and the difference was not statistically significant (P>0.05). After treatment, there was no statistical difference between the test group and the control group in HAMD score, NIHSS score, and BI index (P>0.05). After treatment, there was no statistically significant difference between the test group and the control group in BDNF, NGF, 5-HT, 5-HIAA and NE (P>0.05). The incidence of adverse reactions in the experimental group and the control group were 17.02% and 19.14%, respectively, and the difference was not statistically significant (P>0.05).</p> <p><b><span>Conclusion: </span></b>Agomelatine and sertraline hydrochloride have the same clinical efficacy in the treatment of post-stroke depression, and the adverse reactions are relatively mild.</p>
Figure 4 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 4 Modified Stern-Volmer plots for 2H4MBBH-HSA complexes at 15 and 25 °C.
Figure 1 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 1 Synthesis of 2-(2-hydroxy-4-methoxybenzylidene)-1-(1H-benzimidazol-2-yl)hydrazine.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.