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1,921 results for “onset”
Early onset of urea synthesis and ammonia detoxification pathways in three terrestrially developing frogs
<p>Frogs evolved terrestrial development multiple times, necessitating mechanisms to avoid ammonia toxicity at early stages. Urea synthesis from ammonia is a key adaptation that reduces water dependence after metamorphosis. We tested for early expression and plasticity of enzymatic mechanisms of ammonia detoxification in three terrestrial-breeding frogs: foam-nest-dwelling larvae of <em>Leptodactylus fragilis </em>(Lf) and arboreal embryos of <em>Hyalinobatrachium fleischmanni</em> (Hf) and <em>Agalychnis callidryas</em> (Ac). Activity of two ornithine-urea cycle (OUC) enzymes, arginase and CPSase 1, and levels of their products urea and CP in tissues were high in Lf regardless of nest hydration but reduced in experimental low- vs. high-ammonia environments. High OUC activity in wet and dry nests, comparable to that under experimental high ammonia, suggests terrestrial Lf larvae maintain high capacity for urea excretion regardless of their immediate risk of ammonia toxicity. This may aid survival through unpredictably long waiting periods before rain enables their transition to water. Moderate levels of urea and CP were present in Hf and Ac tissues and enzymatic activities were lower than in Lf. In both species, embryos in drying clutches can hatch and enter the water early, behaviorally avoiding ammonia toxicity. Moreover, glutamine synthetase is active in early stages of all three species, condensing ammonia and glutamate to glutamine as another mechanism of detoxification. Enzyme activity appeared highest in Lf, although substrate and product levels were higher in Ac and Lf. Our results reveal that multiple biochemical mechanisms of ammonia detoxification occur in early life stages of anuran lineages that evolved terrestrial development.</p>
Bioimpedance phase angle as a prognostic tool in late-onset pompe disease: a single-centre prospective study with a 15-year follow-up
<p>We reported the long-term follow-up of a population of Late onset Pompe disease treated with enzyme replacement therapy. Among predictors of treatment effectiveness and prognosis, we include body composition assessment by bioelectrical vectorial impedance.</p> <p><strong>Methods. </strong>In this single Centre, prospective study, we evaluate the response to enzyme replacement therapy in 15 patients (7 males) with LOPD in different stages of disease, aged 49.4+16.1, followed-up for 15 years. Treatment response was measured by the six-minute walking test, vital capacity in supine and upright position, respiratory muscle strength, muscle MRI, manual muscle testing. We investigated the usefulness of Body Impedance Vectorial Analysis for serial body composition assessment.</p> <p><strong>Results (in brief). </strong>Although most patients with LOPD benefit from long-term treatment, some secondary decline may occur after the first 3-5 years. Some nutritional (lower body mass index, higher fat free mass, higher phase angle) and disease parameters (higher creatinine and shorter disease duration at the beginning of treatment) seem to predict a better motor outcome. Lower Phase Angle may reflect loss of integrity of skeletal muscle membranes, resulting from lysosomal and autophagosomal dysregulation; this leads to treatment mis-targeting, and thus to worse treatment response, and ultimately to whole cell damage. Indeed, the muscle is one of the tissue with the highest rate of autophagosome formation and degradation. </p>
Data from: Interactions between beech and oak seedlings can modify the effects of hotter droughts and the onset of hydraulic failure
<p><span>Mixing species with contrasting resource use strategies could</span><span> reduce forest vulnerability to extreme events. Yet, how species diversity affects seedling hydraulic responses to heat and drought, including mortality risk, is largely unknown.</span></p> <p><span>Using open-top chambers, </span><span>we assessed how, over several years, species interactions (monocultures vs. mixtures) modulate heat and drought impacts on the hydraulic traits </span><span>of juvenile European beech and pubescent oak. Using modelling, we estimated species interaction effects on timing to drought-induced mortality and the underlying mechanisms driving these impacts. </span></p> <p><span>We show that mixtures mitigate adverse heat and drought impacts for oak (less negative </span><span>leaf water potential, higher stomatal conductance, and delayed stomatal closure) but enhance them for beech (lower water potential and stomatal conductance, narrower leaf safety margins, faster tree mortality). Potential underlying mechanisms include oak's larger canopy and higher </span><span>transpiration</span><span>, allowing for quicker exhaustion of soil water in mixtures.</span></p> <p><span>Our findings highlight that diversity has the potential to alter the effects of extreme events, which would ensure that some species persist even if others remain sensitive. Among the many processes driving diversity effects, differences in canopy size and transpiration associated to the stomatal regulation strategy seem the primary mechanisms driving mortality vulnerability in mixed seedling plantations.</span></p>
Effects of Recombinant Human Glutamic Acid Decarboxylase on the Progression of Type 1 Diabetes in New Onset Subjects
ClinicalTrials.gov study NCT00529399. IPD Sharing: YES. Countries: 2. Publications: 7.
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03373383. IPD Sharing: YES. Countries: 19. Publications: 2.
Boston Early-Onset Chronic Obstructive Pulmonary Disease (COPD) Study
ClinicalTrials.gov study NCT01177618. IPD Sharing: YES. Countries: 1. Publications: 7.
Efficacy and Safety of Gefapixant (MK-7264) in Adult Participants With Recent Onset Chronic Cough (MK-7264-043)
ClinicalTrials.gov study NCT04193202. IPD Sharing: YES. Countries: 12. Publications: 1.
Evaluate Onset of Effect in Patients With Chronic Obstructive Pulmonary Disease (COPD) Treated With Formoterol Turbuhaler®
ClinicalTrials.gov study NCT01048333. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Study With an Open-label Extension Phase to Evaluate the Efficacy and Safety of Perampanel (E2007) Administered as an Adjunctive Therapy in Subjects With Refractory Partial-onset Seizures
ClinicalTrials.gov study NCT01618695. IPD Sharing: Not stated. Countries: 7. Publications: 2.
Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures
ClinicalTrials.gov study NCT00464269. IPD Sharing: Not stated. Countries: 5. Publications: 16.
A Phase 2, Multicentre, Randomized, Double-blind, Placebo-controlled Study in Patients With New-onset Type 1 Diabetes
ClinicalTrials.gov study NCT02814838. IPD Sharing: NO. Countries: 3. Publications: 1.
Exploratory Muscle Biopsy Assessment Study in Patients With Late-Onset Pompe Disease Treated With Alglucosidase Alfa
ClinicalTrials.gov study NCT01288027. IPD Sharing: Not stated. Countries: 4. Publications: 1.
A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Art
ClinicalTrials.gov study NCT04527380. IPD Sharing: YES. Countries: 12. Publications: 0.
Trial to Demonstrate the Efficacy and Safety of Conversion to Lacosamide Monotherapy for Partial-onset Seizures
ClinicalTrials.gov study NCT00520741. IPD Sharing: Not stated. Countries: 13. Publications: 1.
EARLY 3-months Aggrenox Treatment Started Within 24 Hrs of Ischemic Stroke Onset vs. After One Week 100 mg ASA
ClinicalTrials.gov study NCT00562588. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Albiglutide Versus Placebo in Insulin-treated Subjects With New-onset Type 1 Diabetes Mellitus
ClinicalTrials.gov study NCT02284009. IPD Sharing: YES. Countries: 5. Publications: 1.
A Double-Blind, Randomized, Placebo-Controlled, Phase 2 Trial of YKP3089 as Adjunctive Therapy in Subjects With Partial Onset Seizures
ClinicalTrials.gov study NCT01866111. IPD Sharing: Not stated. Countries: 15. Publications: 4.
Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation
ClinicalTrials.gov study NCT01002339. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes
ClinicalTrials.gov study NCT00378508. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Double-blind, Randomized Study Evaluating the Efficacy and Safety of Brivaracetam in Adults With Partial Onset Seizures
ClinicalTrials.gov study NCT00490035. IPD Sharing: Not stated. Countries: 12. Publications: 17.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.