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302
datasets available to search
ShareScore release 0.9.0
Dataset results
302 results for “pacemaking”
Natural History and Results of Dual Chamber (DDD) Pacemaker Therapy of Children With Obstructive Hypertrophic Cardiomyop...
ClinicalTrials.gov study NCT00001396. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Pacemaker Therapy for Drug-refractory Symptoms in Mid-cavity Hypertrophic Cardiomyopathy
ClinicalTrials.gov study NCT03450252. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Diaphragmatic Pacemaker in Tetraplegic Patients With Spinal Cord Injuries
ClinicalTrials.gov study NCT01385384. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cost-Effectiveness of Routine Follow-up Visits in Patients With a Pacemaker: The Followpace Study
ClinicalTrials.gov study NCT00135174. IPD Sharing: Not stated. Countries: 1. Publications: 5.
NOL Index in Response to Pacemaker Stimulation
ClinicalTrials.gov study NCT06696781. IPD Sharing: NO. Countries: 1. Publications: 1.
Pacemaker Implantation Versus Cardioneuroablation for Functional Atrioventricular Block
ClinicalTrials.gov study NCT05774262. IPD Sharing: YES. Countries: 1. Publications: 21.
Optimising Pacemaker Therapy for Contractility
ClinicalTrials.gov study NCT02964650. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Outcome of Patients Undergoing Leadless Pacemaker Implantaton
ClinicalTrials.gov study NCT06656468. IPD Sharing: NO. Countries: 1. Publications: 1.
Zero-fluoroscopic Navigation Versus Conventional Fluoroscopic Navigation for Single-chamber Pacemaker Implantation
ClinicalTrials.gov study NCT03118440. IPD Sharing: NO. Countries: 1. Publications: 7.
The CT-verified Data Collection Study to Investigate the Correlation Between the Leadless Pacemaker Tip Location and Echo, ECG
ClinicalTrials.gov study NCT06910059. IPD Sharing: NO. Countries: 1. Publications: 3.
Pacing the Atrium to Confirm or Exclude Pacemaker Indication in TAVI
ClinicalTrials.gov study NCT05278585. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sub-threshold Pacing to Prevent Pacemaker-induced Ventricular Tachycardia
ClinicalTrials.gov study NCT01906775. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Magnetic Resonance Imaging (MRI) in Patients With Pacemakers and Implanted Cardioverter Defibrillators
ClinicalTrials.gov study NCT02888353. IPD Sharing: YES. Countries: 1. Publications: 2.
Targeted Left Ventricular Lead Placement, Comparison of Active Fixation Bipolar and Passive Quadripolar Pacemaker Leads
ClinicalTrials.gov study NCT04632472. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Safety of Leadless Pacemakers Versus Left Bundle Area Pacing - A Preliminary Exploration
ClinicalTrials.gov study NCT06690333. IPD Sharing: NO. Countries: 1. Publications: 13.
A Comparison of Rate Response Performance in Pacemaker Patients With an Indication of Sinus Node Dysfunction
ClinicalTrials.gov study NCT02027909. IPD Sharing: NO. Countries: 1. Publications: 3.
Organelle calcium-derived voltage oscillations in pacemaker neurons drive the motor program for food-seeking behavior in Aplysia
Open the record for dataset details and reuse information.
Data from: Drosophila clock is required in brain pacemaker neurons to prevent premature locomotor aging independently of its circadian function
Circadian clocks control many self-sustained rhythms in physiology and behavior with approximately 24-hour periodicity. In many organisms, oxidative stress and aging negatively impact the circadian system and sleep. Conversely, loss of the clock decreases resistance to oxidative stress, and may reduce lifespan and speed up brain aging and neurodegeneration. Here we examined the effects of clock disruptions on locomotor aging and longevity in Drosophila. We found that lifespan was similarly reduced in three arrhythmic mutants (ClkAR, cyc0 and tim0) and in wild-type flies under constant light, which stops the clock. In contrast, ClkAR mutants showed significantly faster age-related locomotor deficits (as monitored by startle-induced climbing) than cyc0 and tim0, or than control flies under constant light. Reactive oxygen species accumulated more with age in ClkAR mutant brains, but this did not appear to contribute to the accelerated locomotor decline of the mutant. Clk, but not Cyc, inactivation by RNA interference in the pigment-dispersing factor (PDF)-expressing central pacemaker neurons led to similar loss of climbing performance as ClkAR. Conversely, restoring Clk function in these cells was sufficient to rescue the ClkAR locomotor phenotype, independently of behavioral rhythmicity. Accelerated locomotor decline of the ClkAR mutant required expression of the PDF receptor and correlated to an apparent loss of dopaminergic neurons in the posterior protocerebral lateral 1 (PPL1) clusters. This neuronal loss was rescued when the ClkAR mutation was placed in an apoptosis-deficient background. Impairing dopamine synthesis in a single pair of PPL1 neurons that innervate the mushroom bodies accelerated locomotor decline in otherwise wild-type flies. Our results therefore reveal a novel circadian-independent requirement for Clk in brain circadian neurons to maintain a subset of dopaminergic cells and avoid premature locomotor aging in Drosophila.
Raw Data for the article: Permanent pacemaker implantation after valve and arrhythmia surgery in patients with preoperative atrial fibrillation
<p><strong>Background: </strong>Among patients referred for cardiac surgery, atrial fibrillation (AF) is a common comorbidity and a risk factor for postoperative arrhythmias (eg, sinus node dysfunction, atrioventricular heart block), including those requiring permanent pacemaker (PPM) implantation.</p> <p><strong>Objective: </strong>The purpose of this study was to evaluate the prevalence and long-term survival of postoperative PPM implantation in patients with preoperative AF who underwent valve surgery with or without concomitant procedures.</p> <p><strong>Methods: </strong>Presented analysis pertains to the HEIST (HEart surgery In atrial fibrillation and Supraventricular Tachycardia) registry. During the study period, 11,949 patients underwent valvular (aortic, mitral, or tricuspid valve replacement or repair) surgery and/or surgical ablation (SA) and were stratified according to postoperative PPM status.</p> <p><strong>Results: </strong>PPM implantation after surgery was necessary in 2.5% of patients, with significant variation depending on the type of surgery (from 1.1% in mitral valve repair to 3.3% in combined mitral and tricuspid valve surgery). In a multivariate logistic regression model, tricuspid intervention (P <.001), cardiopulmonary bypass time (P = .024), and endocarditis (P = .014) were shown to be risk factors for PPM. Over long-term follow-up, PPM was not associated with increased mortality compared to no PPM (hazard ratio 0.96; 95% confidence interval 0.77-1.19; P = .679). SA was not associated with PPM implantation. However, SA improved survival regardless of PPM status (log rank P <.001).</p> <p><strong>Conclusion: </strong>In patients with preoperative AF, the need for PPM implantation after valve surgery or SA is not an infrequent outcome, with SA not affecting its prevalence but actually improving long-term survival.</p>
Application of the "Haemoblock" in Pacemaker Patients
ClinicalTrials.gov study NCT04559646. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
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OpenNeuro
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