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880 results for “pathogenesis”
Macrophage-derived IL-6 trans-signaling as a novel target in the pathogenesis of bronchopulmonary dysplasia (RNA-seq-P14-HYXvsNOX)
<p><strong>Rationale:</strong> Premature infants exposed to oxygen are at risk for bronchopulmonary dysplasia (BPD), which is characterized by lung growth arrest. Inflammation is important, but the mechanisms remain elusive. Here, we investigated inflammatory pathways and therapeutic targets in severe clinical and experimental BPD.</p> <p><strong>Methods and Results:</strong> First, transcriptomic analysis with in-silico cellular deconvolution identified a lung-intrinsic M1-like-driven cytokine pattern in newborn mice after hyperoxia. These findings were confirmed by gene expression of macrophage-regulating chemokines (Ccl2, Ccl7, Cxcl5) and markers (Il6, Il17A, Mmp12). Second, hyperoxia-activated IL-6/STAT3 signaling was measured in vivo and related to loss of alveolar epithelial type II cells (ATII) as well as increased mesenchymal marker. Il6 null mice exhibited preserved ATII survival, reduced myofibroblasts and improved elastic fiber assembly, thus enabling lung growth and protecting lung function. Pharmacological inhibition of global IL-6 signaling and IL-6 trans-signaling promoted alveolarization and ATII survival after hyperoxia. Third, hyperoxia triggered M1-like polarization, possibly via Klf4; hyperoxia-conditioned medium of macrophages and IL-6 impaired ATII proliferation. Finally, clinical data demonstrate elevated macrophage-related plasma cytokines as potential biomarkers that identify infants receiving oxygen at increased risk of developing BPD. Moreover, macrophage-derived IL6 and active STAT3 were related to loss of epithelial cells in BPD lungs.</p> <p><strong>Conclusion:</strong> We present a novel IL-6-mediated mechanism by which hyperoxia activates macrophages in immature lungs, impairs ATII homeostasis, and disrupts elastic fiber formation, thereby inhibiting lung growth. The data provide evidence that IL-6 trans-signaling could offer an innovative pharmacological target to enable lung growth in severe neonatal chronic lung disease.</p>
Datasets for the paper "Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis."
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Supporting Data for computational analysis in Nanoplastics Potentiate Alzheimer's Pathogenesis by Promoting the Microglial Escape of Amyloid Beta
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Supporting Data for simulation part in Nanoplastic potentiates Alzheimer's pathogenesis
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Single Cell Analysis of the Pathogenesis of Pediatric Nephrotic Syndrome
<p>This is ScRNAseq datasets used to analyses the pathogenesis of nephrotic syndrome. </p>
Data from: Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis
Macrophages and neutrophils are the first responders to invading pathogens and contribute strongly to the host defense against intracellular pathogens. The collective interplay and dynamic interactions between these leukocytes are to a large extent not understood. In the present study, we have investigated their role using a combination of confocal laser-scanning and electron microscopy in a zebrafish model for tuberculosis, a local Mycobacterium marinum infection in the tissue of the larval tail fin. Our results show that neutrophils are efficient in phagocytosis of mycobacteria and that they contribute largely to their dissemination. Macrophages appear to play a major role in efferocytosis, phagocytosis of dead cells that contain bacterial content. Phagocytic cells with large bacterial aggregates are formed that can be extruded out of the tissue after cell death. Alternatively, these excessively infected cells can undergo necrosis leading to immediate recruitment of surrounding leukocytes and subsequent phagocytosis of released bacteria. Our data show that these necrotic burst events result in progression of the infection, whereas extrusion abates the infection.
Supporting data files: Exploring the early molecular pathogenesis of osteoarthritis using differential network analysis of human synovial fluid
<p><strong>SS-218412_v4.1_other.hybNorm.medNormInt.plateScale.medNormSMP.adat</strong></p> <p>Main raw data file - normalized aptamer abundances</p> <p><strong>m4.L1_0.1_L2_0.001_ITER_10K_STABILITYSS_1K.rds</strong></p> <p>R data file object - GGM model output used in manuscript</p>
Study of the Pathogenesis of Rett Syndrome
ClinicalTrials.gov study NCT00004807. IPD Sharing: Not stated. Countries: 0. Publications: 9.
Pathogenesis of Stress-Induced Cardiomyopathy by I-123 MIBG
ClinicalTrials.gov study NCT01432626. IPD Sharing: NO. Countries: 1. Publications: 0.
Pathogenesis of Adverse Drug Reactions
ClinicalTrials.gov study NCT00224952. IPD Sharing: Not stated. Countries: 1. Publications: 0.
IL37,Tlymphocytes,NK Cells in Pathogenesis of ITP
ClinicalTrials.gov study NCT04482777. IPD Sharing: Not stated. Countries: 0. Publications: 4.
The Pathogenesis of Inflammatory Synovitis: A Study of Early Arthritis
ClinicalTrials.gov study NCT00001375. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Possible Association of Intestinal Helminths and Protozoa With Colorectal Cancer Pathogenesis
ClinicalTrials.gov study NCT03173001. IPD Sharing: UNDECIDED. Countries: 0. Publications: 1.
Impact of Different Dietary IgGs on the Pathogenesis of IBD
ClinicalTrials.gov study NCT03885479. IPD Sharing: UNDECIDED. Countries: 0. Publications: 7.
Evaluation of Pyroptosis-related Indicators in the Pathogenesis of Vitiligo:Across-sectional Comparative Study
ClinicalTrials.gov study NCT06261086. IPD Sharing: UNDECIDED. Countries: 0. Publications: 4.
Role of Vitamin D and Its Topical Analogues in Pathogenesis and Treatment of Acne Vulgaris
ClinicalTrials.gov study NCT03866447. IPD Sharing: NO. Countries: 0. Publications: 10.
The Role of the Duodenum in the Pathogenesis of Insulin Resistance and Type 2 Diabetes Mellitus
ClinicalTrials.gov study NCT00568620. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure
ClinicalTrials.gov study NCT03590522. IPD Sharing: Not stated. Countries: 0. Publications: 5.
Hypoxia-induced Autophagy in the Pathogenesis of MAP
ClinicalTrials.gov study NCT05817448. IPD Sharing: Not stated. Countries: 0. Publications: 12.
The Natural History and Pathogenesis of Mucolipidosis Type IV
ClinicalTrials.gov study NCT00015782. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.