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120
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ShareScore release 0.9.0
Dataset results
120 results for “unfolded protein response”
N-octanoyl dopamine treatment of endothelial cells induces the unfolded protein response and results in hypometabolism and tolerance to hypothermia
GEO Series GSE56285. Homo sapiens. 5 samples. Type: Expression profiling by array.
Relevance of Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis
Plants are primary producers of food and oxygen on Earth and will likewise be indispensable to the establishment of large-scale sustainable ecosystems and human survival in space. To contribute to the understanding of how plants respond to spaceflight stresses, we examined the relevance of the unfolded protein response (UPR), a conserved signaling cascade that responds to a number of unfavorable environmental stresses, in the model plant species Arabidopsis thaliana. To do so, we compared the transcriptional responses of wild type and UPR-defective seedlings to spaceflight during the SpaceX-CRS12 mission to the International Space Station. We established that orbital culture substantially altered the expression of hundreds of stress related genes compared to ground control conditions. Although many of these genes were differentially regulated in the UPR mutants in the ground control conditions compared to wild type, their expression was largely equalized in all genotypes by flight. Our results have yielded new information on how plants respond to growth in orbit and support the hypothesis that spaceflight induces the activation of signaling pathways that compensate for the loss of UPR regulators in the control of downstream transcriptional regulatory networks.
RNA sequencing (RNA-seq) for identifing differentially expressed genes for mitochondrial unfolded protein response in Arabidopsis
GEO Series GSE198496. Arabidopsis thaliana. 9 samples. Type: Expression profiling by high throughput sequencing.
Designed, linked-domain proteins are pan-UBE2D inhibitors and induce proteostress and the unfolded protein response in HeLa cells
GEO Series GSE298221. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the IRE1/XBP1 unfolded protein response (UPR) pathway in Schmid metaphyseal chondrodysplasia hypertrophic chondrocyte endoplasmic reticulum (ER) stress
GEO Series GSE72261. Mus musculus. 12 samples. Type: Expression profiling by array.
AGAL misprocessing-induced ER stress and the unfolded protein response: lysosomal storage-independent mechanism of Fabry disease pathogenesis?
GEO Series GSE271756. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
AI662270-GRP94 axis couples the unfolded protein response to mitochondrial dynamics during acute myocardial infarction
GEO Series GSE304427. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
The unfolded protein response gene Ire1α is required for tissue renewal and normal differentiation in the mouse tongue and esophagus
GEO Series GSE205488. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Type 1 calreticulin mutations activate the IRE1α-XBP1 pathway of the unfolded protein response to drive MPN
GEO Series GSE173805. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Modulating the unfolded protein response: Impacts of radiation on the response of prostate cancer cells to ONC201.
GEO Series GSE136975. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
KDSR is required for 3-ketodihydrosphingosine metabolism and ER unfolded protein response in leukemia
GEO Series GSE167688. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Dual role of the unfolded protein response in the therapeutic effect of AZD1775 on TP53 mutant high grade serous ovarian cancer
GEO Series GSE166417. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
HERV1-env dependent unfolded protein response activation is a potential initiator of T cell autoreactivity in autoimmune liver disease.
GEO Series GSE135410. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Unfolded protein response (UPR) and endoplasmic reticulum (ER) stress in acromegaly
GEO Series GSE153755. Danio rerio. 33 samples. Type: Expression profiling by high throughput sequencing.
PTEN deficiency in TNBC provides vulnerability to co-targeting KDM4B and PI3K through over-activation of Unfolded Protein Response pathway
GEO Series GSE103018. Homo sapiens. 6 samples. Type: Expression profiling by array.
Rosemary polyphenols induce unfolded protein response and changes in cholesterol metabolism in colon cancer cells
GEO Series GSE65722. Homo sapiens. 9 samples. Type: Expression profiling by array.
Mitochondrial unfolded protein response gene Clpp plays a role in female fertility and reproductive aging
GEO Series GSE102269. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Unfolded Protein Response Regulator, ATF6, is Essential for Cone Photoreceptor Development
GEO Series GSE153302. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in hematopoietic cells
GEO Series GSE102900. Homo sapiens. 9 samples. Type: Expression profiling by array.
Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR)
GEO Series GSE27349. Homo sapiens; Mus musculus. 28 samples. Type: Expression profiling by array.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.