Find research datasets worth reusing

opencc-by-4.0Aug 2015View details →

Figure 6.Amygdala hypofunction after a single oral 40-mg dose, 1.5-hours post-dose, in young study participants.The image has been adapted from (Hurlemann et al., 2010).-The Brain and Propranolol Pharmacokinetics in the Elderly

In the past decade, there has been much interest in identifying treatment in adding to the current treatment options for war veterans suffering from Post-Traumatic Stress Disorder (PTSD). The studies investigating secondary-preventative measures for PTSD using Propranolol due to the drug’s ability to inhibit the actions of the neurotransmitter norepinephrine,which has been implicated to enhance the consolidation(McGhee et al., 2009; Pitman et al., 2002; Stein et al., 2007).Further, in a double-blind, placebo-controlled,functional Magnetic Resonance Imaging (fMRI) study, in healthy volunteers, Hurlemann et al. found that a single oral 40mg dose of propranolol attenuatedthe leftbasolateral amygdala responses to the face perception paradigm(Hurlemann et al., 2010). The study participants were eighteen healthy (9 females, 9 males; mean age 23 years; age range 19–31 years) who had their fMRI acquisition 1.5-hours after the oral administration of propranolol. An adapted image of the study findings are shown in Figure 6.

opencc-by-4.0Jan 2018View details →

Figure 4. Simulation (Monte-Carlo, n=200) results elderly patients taking a 10mg oral dose resulting in similar Cmax, maximum plasma concentration, to the young patients taking a 40mg oral dose. The dotted lines illustrate the 10th and 90th percentiles of plasma levels of the elderly population with a 10mg oral administration of propranolol.-The Brain and Propranolol Pharmacokinetics in the Elderly

Thus, the package insert (see 1) recommends clinicians start at the lower end of the dosing range, without further details. Similarly, Pfizer manufactures Inderal® LA (Propranolol HCI), which is the long-acting form of propranolol and their package insert (see 2) states, “There is no information available for elderly patients.” Though the kinetics for the long-acting formdiffers from the standard form, manufactured by Wyeth, we would suspect a 10mg dose for the elderly would achieve a similar maximum plasma concentration (Cmax) to that of the younger patient cohort.This 10mg, which is 25% of the original 40mg, dosing schedule is based on our simulations at 10mg in the geriatric population.

opencc-by-sa-4.0Apr 2018View details →

Influence of young age microbiome on adult sleep behavior in D. Melanogaster

There is growing evidence for the interaction between the gut microbiome and the brain. Several studies report strong correlations between the composition of the gut microbiome and various neurological diseases. Moreover, gut bacteria are shown to influence levels of neurotransmitters, e.g GABA, which are unbalanced in stress related disorders, such as anxiety and depression but also in in sleep disorders. Drosophila Melanogaster is a powerful model organism for investigating the interaction between the microbiome and the brain. In addition to available genetic techniques, yielding germ free (axenic) flies and establishing gnotobiotic cultures is faster and easier with fruit flies compared to other model organisms. Moreover, Drosophila microbiome is much simpler in complexity, in contrast to the vertebrate microbiome. We investigated the significance of the young age microbiome on adult sleep behaviour in Drosophila. Our hypothesis was that differences in microbiome composition might elucidate the reason for the behavioral variability in resilience/vulnerability to sleep deprivation, amongst individuals with same genetic background. However, our results suggest that there is no/ minor effect of the Drosophila microbiome on sleep behaviour.

opencc-by-4.0Nov 2018View details →

Observing substructure in circumstellar discs around massive young stellar objects

Synthetic dust continuum and molecular line Atacama Large Millimetre Array (ALMA) observations of massive, self-gravitating disc models surrounding massive young stellar objects are presented here. Semi-analytic models of self-gravitating discs with spiral density waves and clumps/fragments are combined with radiative transfer models, and synthetic observations are produced using CASA software. Models presented here have different disc masses, distances, inclinations, thermal structures, dust distributions, number and orientation of spirals and fragments.              Data is in the FITS format, with filenames starting either with 'line' (synthetic molecular line datacube) or 'cont' (synthetic continuum images), and each filename contains the model ID. Tables of model IDs and model parameters are given in files models_table_spiral.dat and models_table_spiral_fragments.dat for models without and with fragments, respectively. Starting from a fiducial disc model, model parameters were varied one by one, with the exception of disc inclination which is separately set in each model.              For details about the model parameters, detailed presentation of methods, proposed substructure-enhancing filtering methods, discussion and predictions for the upcoming ALMA observations, see Jankovic et al. 2018 (accepted for publication in MNRAS, arxiv.org/abs/1810.11398).

opencc-by-4.0Dec 2018View details →

Dataset (encounter histories of female bats) used in the analysis for the paper Culina et al.: Live fast, don't die young: survival reproduction trade-offs in long-lived income breeders

Two data files (Md_capture_H, Mn_capture_H) represent the capture histories of females of two species (Myotis daubentonii = Md, and M. nattereri=Mn). These capture histories were used to run multi-event-capture-mark-recapture model, as described in the paper, and in the readme document in this data package.

opencc-by-nc-nd-4.0Jul 2019View details →

Our Mythical History: Children's and Young Adults' Culture in Response to the Heritage of Ancient Greece and Rome

A short movie from the international conference  Our Mythical History: Children’s and Young Adults’ Culture in Response to the Heritage of Ancient Greece and Rome held at the Faculty of "Artes Liberales", University of Warsaw, May 22-26, 2019 available at <a href="https://www.youtube.com/watch?v=jVeEjWSCXD8">https://www.youtube.com/watch?v=jVeEjWSCXD8</a>  Music: Brave by WildKitty Tunes, Video: Mirosław Kaźmierczak, Coordination: Katarzyna Marciniak Art works used in the movie: Matylda Tracewska, Zbigniew Karaszewski

opencc-by-4.0Nov 2019View details →

Splicing patterns of the Arabidopsis organellar rhomboid At1g74140 change during development from young to mature leaf tissues.

Background to the study: Four distinct rhomboid genes appear to function in Arabidopsis plastids, two “active” types from the secretases and presenilin-like associated rhomboid-like (PARL) categories (At1g25290 and At5g25752) and two “inactive” rhomboid forms (At1g74130 and At1g74140).  The number of working rhomboids is further increased by alternative splicing, two reported for At1g25290 and three for At1g74130.  Since At1g25290 and At1g74130 exist as alternative splice variants, it would be necessary to assess the splicing patterns of the other two plastid rhomboid genes, At5g25752 and At1g74140, before studying the Arabidopsis plastid rhomboid system as a whole.   Method used: This study thus specifically focused on an analysis of the At1g74140 transcript population using various RT-PCR strategies. The supplementary table provides the details of the various RT-PCR primers used in this study. Results of the study and their relationship to the supplementary figures deposited here: The exon mapping results indicate splicing patterns different from the close relative At1g74130, despite similarity between the exonic sequences.  The splicing patterns indicate a high level of sequence “discontinuity” in the At1g74140 transcript population with a significant portion of the discontinuity being generated by two regions of the gene. The three supplementary figures of RT-PCR results deposited here provide further evidence that the alternatively spliced short transcript products from the discontinuous splicing patterns fluctuate during development. Conclusion of the main study and its relationship to the supplementary results deposited here: The overall discontinuous splicing pattern of At1g74140 may be reflective of its mode of involvement in activities like controlling gene expression.  The developmental evidence in these deposited supplementary RT-PCR results indicate that some of the alternatively spliced short transcript products fluctuate between mature and young tissues, suggesting that the short transcripts bear functional significance.

opencc-by-4.0Sep 2013View details →

Text-fig. 4. Trichopeziza violascens (PRM 915197). a. ascospores; b. hairs; c. paraphyses; d. asci; e. young asci with croziers. Scale bars: a, b, c, d-e = 10 µm. in A Revision Of Trichopeziza Lizonii, T. Sulphurea And T. Violascens (Ascomycota, Helotiales) From The Herbarium Prm With Notes On Type Material Of Peziza Sulphurea

Text-fig. 4. Trichopeziza violascens (PRM 915197). a. ascospores; b. hairs; c. paraphyses; d. asci; e. young asci with croziers. Scale bars: a, b, c, d-e = 10 µm.

opencc-by-4.0Sep 2017View details →

Fig. 12. Spongilla purbeckensis Young, 1878 in Fossil freshwater sponges: Taxonomy, geographic distribution, and critical review

Fig. 12. Spongilla purbeckensis Young, 1878, Spongillida: Spongillidae; Purbeck Limestone, Lower Cretaceous, Stare Cove, Dorset, England. A. Spicules in the spiculite as illustrated by Hinde (1883). B. Spiny oxeas in the drawing of Young (1878). Originally not to scale; it may be inferred from the text that spicules are 450 μm long.

opencc-by-4.0Dec 2017View details →

Рис. 1–6. Lixus pulverulentus. 1 – биотоп, ассоциация Cirsium acanthoides; 2 – Λичинка внутри стебΛя кормового растения; 3 – моΛоÃой жук внутри стебΛя кормового растения; 4 – гоΛова Λичинки; 5 – внешний виÃ Λичинки; 6 – внешний виÃ кукоΛки. Figs 1–6. Lixus pulverulentus. 1 – biotope, Cirsium acantoides association; 2 – larva within the stalk of the host plant; 3 – young beetle inside the stalk of the host plant; 4 – head of the larva; 5 – habitus of the larva; 6 – habitus of the pupa. in Description of the preimaginal stages and biology of the weevil Lixus (Dilixellus) pulverulentus (Scopoli, 1763) (Coleoptera: Curculionidae: Lixini)

Рис. 1–6. Lixus pulverulentus. 1 – биотоп, ассоциация Cirsium acanthoides; 2 – Λичинка внутри стебΛя кормового растения; 3 – моΛоÃой жук внутри стебΛя кормового растения; 4 – гоΛова Λичинки; 5 – внешний виÃ Λичинки; 6 – внешний виÃ кукоΛки. Figs 1–6. Lixus pulverulentus. 1 – biotope, Cirsium acantoides association; 2 – larva within the stalk of the host plant; 3 – young beetle inside the stalk of the host plant; 4 – head of the larva; 5 – habitus of the larva; 6 – habitus of the pupa.

Fig. 6. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 6. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. HGM 41HIII0437, right ulna in anterior (A 1) and posterior (A2) views. B. IVPP V 4017.20, distal end of left radius in posterior (B1), medial (B2), and anterior (B 3) views. C. HGM 41HIII0434, right ilium in lateral (C1) and medial (C2) views. D. IVPP V 4017.10, distal part of right ischium in medial (D1) and lateral (D 2) views. E. IVPP V 4017.9, partial right ischium in lateral view. F. IVPP V 4017.7, proximal part of right pubis in lateral (F1) and anterior (F2) views. D–F were referred to Taihangshania imperfect in Young 1979. G. Pelvic girdle reconstruction showing the position of D–F.

Fig. 2. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 2. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. IVPP V 4017.24, the incomplete left splenial in dorsal (A1) and posterior A2) views. B. IVPP V 4017.25, the incomplete right splenial in dorsal view.

Fig. 5. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 5. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. HGM 41HIII0431, right scapula in lateral (A 1) and medial (A 2) views. B. HGM 41HIII0432, interclavicle in dorsal (B 1) and ventral (B 2) views. C. HGM 41HIII0433, left clavicle in anterior (C 1) and posterior (C 2) views. D. HGM 41HIII0435, left humerus in dorsal (D 1) and ventral (D 2) views. E. HGM 41HIII0436, right humerus in ventral view.

Fig. 1. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 1. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. HGM 41HIII0423, left maxilla with teeth, in lateral (A1) and medial (A2) views. B. IVPP V4012.2, formerly referred to Labyrinthodontia (Young, 1979),?prefrontal in dorsal (B1), ventral (B2), and lateral (B3) views. C. IVPP V4012.1, formerly referred to Labyrinthodontia (Young, 1979), parietal in ventral (C1) and dorsal (C2) views. D. HGM 41HIII0442, incomplete left quadratojugal in lateral (D1) and medial (D2) views. E. HGM 41HIII0425, left dentary with teeth, in lateral (E1) and medial (E2) views. F. HGM 41HIII0441, incomplete left quadrate in anterior (F1), posterior (F2), and ventral (F3) views.

Fig. 4. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 4. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. IVPP V 4017.5, former Taihangshania imperfecta Young, 1979, cervical vertebra in posterior (A 1) and lateral (A 2) views. B. HGM 41HIII0427, dorsal vertebra in anterior (B 1) and posterior (B 2) views. C, D. Sacral vertebrae with ribs. C. HGM 41HIII0428, in anterior (C 1) and posterior (C 2) views. D. HGM 41HIII0429, in posterior (D 1) and anterior (D 2) views. E. IVPP V 4017.27, caudal cervical vertebra in anterior (E 1) and posterior (E 2) views. F. HGM 41HIII0430, incomplete right dorsal rib in lateral view.

Fig. 7. Pareiasaur reptile Honania complicidentata Young, 1979 in The Jiyuan Tetrapod Fauna of the Upper Permian of China: New pareiasaur material and the reestablishment of Honania complicidentata

Fig. 7. Pareiasaur reptile Honania complicidentata Young, 1979 (Upper Permian, Shangshihezi Formation of Jiyuan, Henan Province, China). A. HGM 41HIII0439, right femur in dorsal (A 1) and ventral (A 2) views. B. HGM 41HIII0440, right tibia in posterior (B 1) and anterior (B 2) views. C. HGM 41HIII0443, metatarsal or metacarpal in anterior (C 1) and posterior (C 2) views.

Fig. 2 in A young parasite in an old fish host: A new genus for proteocephalid tapeworms (Cestoda) of bowfin (Amia calva) (Holostei: Amiiformes), and a revised list of its cestodes

Fig. 2. Laruella perplexa (La Rue, 1911) n. comb. from Amia calva. SEM micrographs. A – frontal view of scolex. B, D – subapical view of scolex; note tear-shaped inner rim of suckers. C – apical view of scolex; note apical pit. E – capiliform filitriches on scolex (apical region anterior to suckers – indicated by letter E in Fig. 2B).

Fig. 4 in A young parasite in an old fish host: A new genus for proteocephalid tapeworms (Cestoda) of bowfin (Amia calva) (Holostei: Amiiformes), and a revised list of its cestodes

Fig. 4. Laruella perplexa (La Rue, 1911) n. comb. from Amia calva, Illinois and Mississippi (A–D) and Proteocephalus ambloplitis (Leidy, 1887) from Micropterus dolomieu (E, F). A – terminal genitalia with uterine diverticula near anterior part of proglottids (MHNG-PLAT-0063348), dorsal view; vitelline follicles are not illustrated. B, C – terminal genitalia, frontal section and ventral view of paratype (USNM 1348679). D – posterolateral end of proglottid (MHNG-PLAT-0063348); note band of posterior (median) vitelline follicles bent inwards. E – proximal part of vaginal canal, dorsal view; note numerous loops. F – cirrus-sac, dorsal view; note large, thick-waled vaginal sphincter and strongly convoluted internal sperm duct. Abbreviations: CI - cirrus; CS - cirrus sac; DOC – dorsal osmoregulatory canal; EG – egg; MG – Mehlis' gland; MVF – median vitelline follicles; OV – ovary; SR – seminal receptacle; TE – testes; UD – uterine diverticula; VA – vagina; VD – vas deferens; VF – vitelline follicles; VOC – ventral osmoregulatory canal; VS – vaginal sphincter.

Fig. 1 in A young parasite in an old fish host: A new genus for proteocephalid tapeworms (Cestoda) of bowfin (Amia calva) (Holostei: Amiiformes), and a revised list of its cestodes

Fig. 1. Laruella perplexa (La Rue, 1911) n. comb. from Amia calva (A, B, C, E, G, H) and Proteocephalus ambloplitis (Leidy, 1887) from Micropterus dolomieu (D, F). A, D – anterior part of body with first proglottids. B, C, E, F – scolex, frontal view; B – holotype (USNM 1347286); note narrow sphincters around sucker opening in C, E). G – cross section through scolex; note sphincters on margin of sucker openings; paratype (USNM 1348679). Abbreviations: AO - apical organ; EG – egg; ILM – inner longitudinal musculature; OC – osmoregulatory canals; SS – sucker sphincter; SU – sucker; TE - testes; TG - tegument; UT – uterus; VF – vitelline follicles.

Fig. 3 in A young parasite in an old fish host: A new genus for proteocephalid tapeworms (Cestoda) of bowfin (Amia calva) (Holostei: Amiiformes), and a revised list of its cestodes

Fig. 3. Laruella perplexa (La Rue, 1911) n. comb. from Amia calva, Mississippi, USA (MHNG-PLAT-0063348). A – mature proglottid, ventral view. B – pregravid proglottid, ventral view. Abbreviations: CS - cirrus sac; DOC – dorsal osmoregulatory canal; EG – egg; GP – genital pore; MG – Mehlis' gland; MVF – median vitelline follicles; OC – oocapt; OV – ovary; SR – seminal receptacle; SU – sucker; TE – testes; UD – uterine diverticula; VA – vagina; VD – vas deferens; VF – vitelline follicles; VOC – ventral osmoregulatory canal; VS – vaginal sphincter.