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2,781
datasets available to search
ShareScore release 0.7.1
Dataset results
2,781 results for “older adults”
Protein Supplement and Exercise Training for the Treatment of Sarcopenia Risk in Older Adults
ClinicalTrials.gov study NCT05688956. IPD Sharing: NO. Countries: 1. Publications: 1.
Responders to Rhythmic Auditory Stimulation in Individuals Post-Stroke and Older Adults
ClinicalTrials.gov study NCT06085248. IPD Sharing: YES. Countries: 1. Publications: 17.
Effects of a Healthy Lifestyle Program on Health Outcomes in Older Adults
ClinicalTrials.gov study NCT03576209. IPD Sharing: YES. Countries: 1. Publications: 2.
Effect of an Aural Rehabilitation Program in Hearing-impaired Older Adults
ClinicalTrials.gov study NCT05083221. IPD Sharing: NO. Countries: 1. Publications: 1.
Training Programs Effects on Strength and Balance in Older Adults
ClinicalTrials.gov study NCT05769361. IPD Sharing: NO. Countries: 1. Publications: 1.
Feasibility Study of an Individualized Exergame Training for Older Adults With MI and/or UI (VITAAL)
ClinicalTrials.gov study NCT04587895. IPD Sharing: NO. Countries: 1. Publications: 2.
Improving Outcome for Family Caregivers of Older Adults With Complex Conditions: The Adult Day Plus (ADS Plus) Program
ClinicalTrials.gov study NCT02927821. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Findings from an exploration of a social network intervention to promote diet quality and health behaviours in older adults with COPD: a feasibility study
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Data from: Social brain volume is associated with in-degree social network size among older adults
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Data from: Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
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Clinical characteristics, risk factors and complications of COVID-19 among critically ill older adults – A case control study
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Data from: Endovascular treatment in older adults with acute ischemic stroke in the MR CLEAN Registry
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Kidney function, kidney function decline, and the risk of dementia in older adults: a registry-based study
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Data from: 8-year trends in physical activity, nutrition, TV viewing time, smoking, alcohol and BMI: a comparison of younger and older Queensland adults
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Data from: The risk of new-onset epilepsy and refractory epilepsy in older adult stroke survivors
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Supplemental Materials: Duration of poverty and subsequent cognitive function and decline among older adults in China, 2005-2018
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Data from: Progressive parkinsonism in older adults is related to the burden of mixed-brain pathologies
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Apathy and risk of probable incident dementia among community-dwelling older adults
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Stress: better coping associated with lower tau in amyloid positive cognitively unimpaired older adults
<p><span><b>Objective: </b>Research in animals has shown that chronic stress exacerbates tau pathology. In humans, psychological stress has been associated with higher risk of Alzheimer's disease (AD) clinical syndrome. The objective of this cross-sectional study was <span><span>to assess the hypothesis that</span></span><span> s</span>tress coping ability (assessed via the "Brief Resilience Scale" [BRS]) is associated with tau<span> burden </span><span><span>and to evaluate whether</span></span><span> the</span>se associations differed by sex and amyloid status (A+/A-) in cognitively unimpaired older adults (CU). <b>Methods:</b> We included 225 CU participants (mean age: 70.4±10.2, 48% females) enrolled in the population-based Mayo Clinic Study of Aging who completed the BRS and underwent amyloid-PET (PIB-PET) and tau-PET (AV1451-PET). We fitted multiple regression and ANCOVA models to assess the associations between BRS and tau-PET and the interaction with amyloid status and sex. We focused on entorhinal cortex (ERC) tau burden, and also performed voxel-wise analyses. Age, sex, education, depression and anxiety were considered as covariates. <b>Results:</b> Higher stress coping ability was associated with lower tau burden in the medial temporal lobe (including ERC), occipito-temporal and cuneal/precuneal cortices. The association was present in both A+ and A- but weaker in A- CU older adults. There was an interaction between amyloid status and stress coping ability that was restricted to the medial temporal lobe tau such that A+ CU older adults with lower stress coping abilities showed higher tau. There were no significant interactions between stress coping and sex. <b>Conclusions:</b> A faster termination of the stress response (higher coping ability) may limit the negative effects of stress on tau deposition. Conversely, lower stress coping ability may be an early sign of accumulating tau pathology. Longitudinal studies are warranted to clarify whether stress mechanisms act to exacerbate tau pathology or tau influences stress-related brain mechanisms and lowers the ability to cope with stress. </span></p>
Data from: Immunocompetence in a long-lived ectothermic vertebrate is temperature dependent but shows no decline in older adults
1. Temperature affects nearly all aspects of the physiology of ectotherms, including their ability to mount an immune response. Typically, the ectothermic vertebrate immune system can respond over a wide range of temperatures, but there is a species-specific temperature at which responses are strongest, with impaired responses above and below this threshold. In long-lived ectotherms, aging could also influence the ability to respond to temperature changes as immunosenecence, the functional decrease in immune function with age, is widely reported. 2. This study examined the effects of the interaction between temperature and age on B cell function in a long-lived reptile, the red-eared slider turtle, Trachemys scripta. B cells in this species have previously been shown to have two main functions, phagocytosis and antibody production. 3. Adult turtles were trapped and blood samples taken. Because sliders grow throughout their lifetime, plastron length was used as a proxy for age. Leukocytes were isolated and used in either an ELISpot assay to examine their ability to produce antibodies spontaneously or when stimulated, or used in a phagocytic assay. The ELISpot and phagocytic assays were conducted over a range of biologically relevant temperatures. 4. We found no interaction between age and temperature on any measure of B cell function. In all cases there was a significant effect of temperature, with impaired function at temperatures below 29°C, but no impairment of function at higher temperatures. We also found little evidence of immunosenesce in any response. 5. This study provides insight into the thermal biology of B cell function in sliders and provides an interesting connection between immunology, behavior, and ecology in this long-lived turtle.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.