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2,678 results for “cell signaling”
The Drosophila histone methyl-transferase SET1 coordinates multiple signaling pathways in regulating male germline stem cell maintenance and differentiation
GEO Series GSE254876. Drosophila melanogaster. 24 samples. Type: Expression profiling by high throughput sequencing.
Targeting the NF-κB signaling pathway in Notch1-induced T cell leukemia
GEO Series GSE6396. Mus musculus. 3 samples. Type: Expression profiling by array.
Distinct mesenchymal cell populations generate the essential intestinal BMP signaling gradient
GEO Series GSE130681. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Functional signaling and gene regulatory networks between the oocyte and the surrounding cumulus cells
GEO Series GSE99678. Bos taurus. 48 samples. Type: Expression profiling by high throughput sequencing.
Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility
GEO Series GSE129871. Homo sapiens. 120 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA-221 promotes cell proliferation and inhibit apoptosis in osteosarcoma cells via directly targeting FBXW11 and regulating the Wnt signaling
<p><strong>Figure 1.</strong> miR-221 expression is significantly high in human clinical tissues and cell lines of OS. The expression levels of miR-221 in 30 pairs of OS tissues and their adjacent, non-cancerous normal bone tissues (Normal) (A) and the human osteoblastic cell line hFOB 1.19 and OS cell lines (B) are detected by qRT-PCR. U6 is used as the internal control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 2. </strong>Attenuating miR-221 expression inhibits OS cell proliferation and increase apoptosis. MiR-221 inhibitor is transfected into MG-63-A16 (A) or U2OS cells (B) and induces an obviously lower proliferation rate compared with that in control groups. Further, miR-221 inhibitor is transfected into MG-63-A16 (C) and U2OS cells (D) and triggers a significantly higher apoptosis than controls. And that, the significantly down-regulated Ki67 expression in MG-63-A16 (E) and U2OS cells (F) were observed compared with that in the controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 3. </strong>FBXW11 can directly target to miR-221. (A) An potential target of miR-221, called as FBXW11 has been predicted by bioinformatics-based target prediction analysis, and the binding site is on the 3’UTR of FBXW11. (B) RT-PCR analysis of FBXW11 expression in the OS tumor tissues and noncancerous counterparts. (C) The obviously down-regulated expression levels of FBXW11 mRNA are observed in OS cell lines compared with those in hFOB 1.19 cells. (D) A negative Spearman’s correlation between miR-221 and FBXW11 mRNA levels was observed in 30 OS tumor tissues. (E) The significantly decreased luciferase activity driven by 3’UTR of FBXW11 is observed in the miR-211 mimic group and the 3’UTR-MUT group and negative control are as control. (F) The down-regulation of miR-221 induces a dramatic overexpression of FBXW11 protein. (G) A distinctly lower cell proliferation rate is observed in the group of pcDNA-FBXW11 compared with control. (H) An obviously higher apoptosis is observed in the group of pcDNA-FBXW11 than control. (I) The significantly decreased Ki67 expression is detected in the pcDNA-FBXW11 group than control. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 4.</strong> miR-221 and FBXW11 regulate cell proliferation and apoptosis in OS through inhibiting Wnt signaling. (A) The markedly down-regulated expression levels of β-catenin, cyclin D1 and c-myc were detected in the group of miR-221 inhibitor compared with controls. (B) The obviously decreased expression levels of β-catenin, cyclin D1 and c-myc were determined in the pcDNA-FBXW11 group compared with controls. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p> <p><strong>Figure 5. </strong>The effect of Wnt signaling on the cell proliferation and apoptosis of OS cell lines. A distinctly lower cell proliferation rate (A and B) and an obviously higher apoptosis rate (C and D) were detected in the Wnt1 siRNA groups (siRNA1, siRNA2) than si-control, and similar results were observed in the CGP049090 group. (E and F) The obviously decreased Ki67 expression were detected in the Wnt1 siRNA groups compared with si-control, and similar results were observed in the CGP049090 group. **<em>P</em> < 0.01 and ***<em>P</em> < 0.001.</p>
Data from: Single‐cell profiling screen identifies microtubule‐dependent reduction of variability in signaling
Populations of isogenic cells often respond coherently to signals, despite differences in protein abundance and cell state. Previously, we uncovered processes in the Saccharomyces cerevisiae pheromone response system (PRS) that reduced cell‐to‐cell variability in signal strength and cellular response. Here, we screened 1,141 non‐essential genes to identify 50 "variability genes". Most had distinct, separable effects on strength and variability of the PRS, defining these quantities as genetically distinct "axes" of system behavior. Three genes affected cytoplasmic microtubule function: BIM1, GIM2, and GIM4. We used genetic and chemical perturbations to show that, without microtubules, PRS output is reduced but variability is unaffected, while, when microtubules are present but their function is perturbed, output is sometimes lowered, but its variability is always high. The increased variability caused by microtubule perturbations required the PRS MAP kinase Fus3 and a process at or upstream of Ste5, the membrane‐localized scaffold to which Fus3 must bind to be activated. Visualization of Ste5 localization dynamics demonstrated that perturbing microtubules destabilized Ste5 at the membrane signaling site. The fact that such microtubule perturbations cause aberrant fate and polarity decisions in mammals suggests that microtubule‐dependent signal stabilization might also operate throughout metazoans.
Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses
<p>the key data in our paper "Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses"</p>
Dataset supporting "Blebs Promote Cell Survival by Assembling Oncogenic Signaling Hubs" Weems et al. Nature
<p>All primary data supporting Weems et al. "Blebs Promote Cell Survival by Assembling Oncogenic Signaling Hubs" Nature <span>2023 Mar;615(7952):517-525. </span><span>doi: 10.1038/s41586-023-05758-6</span></p>
Targeting Androgen Signaling in Urothelial Cell Carcinoma - Neoadjuvant
ClinicalTrials.gov study NCT05839119. IPD Sharing: Not stated. Countries: 1. Publications: 0.
VEGF Signaling Promotes Cell Growth and Metastasis in Extrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway (ECC)
ClinicalTrials.gov study NCT02103179. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ERK 1/2 Signaling in Ibrutinib Resistant B-cell Malignancies
ClinicalTrials.gov study NCT04043845. IPD Sharing: YES. Countries: 0. Publications: 0.
Defective FGFR2 Signaling in the Small Airway Basal Progenitor Cells in COPD
ClinicalTrials.gov study NCT02341326. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Immune Modulation by Ischemic Pre-conditioning in Healthy Individuals: Intracellular Signalling in Regulatory Cells
ClinicalTrials.gov study NCT03541239. IPD Sharing: NO. Countries: 1. Publications: 0.
Myeloid Derived Suppressor Cells Control by Signal Regulatory Protein-alpha: Investigation in Hepatocellular Carcinoma
ClinicalTrials.gov study NCT02868255. IPD Sharing: NO. Countries: 0. Publications: 0.
Single-Cell Sequencing Analysis of Radiation Pneumonitis Signals In Patients Treated For Cancer With Radiotherapy
ClinicalTrials.gov study NCT06557343. IPD Sharing: NO. Countries: 1. Publications: 0.
Record Voxel Rate Nonlinear Optical Microscope to Unravel Brain Connectome and Signaling-Establish Reliably Electrophysiological Readouts From Human-induced Pluripotent Stem Cells (hiPSCs)-Derived Cer
ClinicalTrials.gov study NCT05921786. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Paracrine Mechanisms of Bone Marrow Stem Cell Signalling in Chronic Heart Failure
ClinicalTrials.gov study NCT01086787. IPD Sharing: Not stated. Countries: 2. Publications: 0.
VEGF Signaling Promotes Cell Growth and Metastasis in Hepatocellular Carcinoma in a VEGF Receptor Mediated Pathway
ClinicalTrials.gov study NCT01892072. IPD Sharing: Not stated. Countries: 1. Publications: 0.
VEGF Signaling Promotes Cell Growth and Metastasis in Intrahepatic Cholangiocarcinoma in a VEGF Receptor Mediated Pathway
ClinicalTrials.gov study NCT01917370. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.