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1,205 results for “vaccine responses”
Antibody responses to BNT162b2 mRNA vaccine: Infection-naïve individuals with abdominal obesity warrant attention
<p>Malavazos AE, Basilico S, Iacobellis G, Milani V, Cardani R, Boniardi F, Dubini C, Prandoni I, Capitanio G, Renna LV, Boveri S, Rigolini R, Carrara M, Spuria G, Cuppone T, D'acquisto A, Carpinelli L, Sacchi M, Morricone L, Secchi F, Costa E, Menicanti L, Nisoli E, Carruba M, Ambrogi F, Corsi Romanelli MM. Antibody responses to BNT162b2 mRNA vaccine: Infection-naïve individuals with abdominal obesity warrant attention. Obesity (Silver Spring). 2022 Mar;30(3):606-613. doi: 10.1002/oby.23353. Epub 2022 Feb 11. PMID: 34850576.</p> <p>Abstract</p> <p><strong>Objective: </strong>The excess of visceral adipose tissue might hinder and delay immune response. How people with abdominal obesity (AO) will respond to mRNA vaccines against SARS-CoV-2 is yet to be established. SARS-CoV-2-specific antibody responses were evaluated after the first and second dose of the BNT162b2 mRNA vaccine, comparing the response of individuals with AO with the response of those without, and discerning between individuals with or without prior infection.</p> <p><strong>Methods: </strong>Immunoglobulin G (IgG)-neutralizing antibodies against the Trimeric complex (IgG-TrimericS) were measured at four time points: at baseline, at day 21 after vaccine dose 1, and at 1 and 3 months after dose 2. Nucleocapsid antibodies were assessed to detect prior SARS-CoV-2 infection. Waist circumference was measured to determine AO.</p> <p><strong>Results: </strong>Between the first and third month after vaccine dose 2, the drop in IgG-TrimericS levels was more remarkable in individuals with AO compared with those without AO (2.44-fold [95% CI: 2.22-2.63] vs. 1.82-fold [95% CI: 1.69-1.92], respectively, p < 0.001). Multivariable linear regression confirmed this result after inclusion of assessed confounders (p < 0.001).</p> <p><strong>Conclusions: </strong>The waning antibody levels in individuals with AO may further support recent recommendations to offer booster vaccines to adults with high-risk medical conditions, including obesity, and particularly to those with a more prevalent AO phenotype.</p>
Dataset related to article "Transcriptomic profile of TNFhigh MAIT cells is linked to B cell response following SARS-CoV-2 vaccination"
<p>This record contains raw data related to article “<em>Transcriptomic profile of TNF<sup>high</sup> MAIT cells is linked to B cell response following SARS-CoV-2 vaccination"</em></p> <p><strong>ABSTRACT</strong></p> <p><strong>Introduction:</strong> Higher frequencies of Mucosal-associated invariant T (MAIT) cells were associated with an increased adaptive response to mRNA <em>BNT162b2</em> SARS-CoV-2 vaccine, however, the mechanistic insights into this relationship are unknown. Here, we hypothesized that the TNF response of MAIT cells supports B cell activation following SARS-CoV-2 immunization.</p> <p><strong>Methods:</strong> To investigate the effects of repeated SARS-CoV-2 vaccinations on the peripheral blood mononuclear cells (PBMCs), we performed a longitudinal single cell (sc)RNA-seq and scTCR-seq analysis of SARS-CoV-2 vaccinated healthy adults with two doses of the Pfizer-BioNTech <em>BNT162b2 </em>mRNA vaccine. Collection of PBMCs was performed 1 day before, 3- and 17-days after prime vaccination, and 3-days and 3-months following vaccine-boost. Based on scRNA/TCR-seq data related to regulatory signals induced by the vaccine, we used computational approaches for the functional pathway enrichment analysis (Reactome), dynamics of the effector cell-polarization (RNA Velocity and CellRank) and cell-cell communication (NicheNet).</p> <p><strong>Results:</strong> We identified MAIT cells as an important source of TNF across circulating lymphocytes in response to repeated SARS-CoV-2 <em>BNT162b2</em> vaccination. The <em>TNF<sup>high</sup></em> signature of MAIT cells was induced by the second administration of the vaccine. Notably, the increased <em>TNF</em> expression was associated with MAIT cell proliferation and efficient anti-SARS-CoV-2 antibody production. Finally, by decoding the ligand-receptor interactions and incorporating intracellular signaling, we predicted <em>TNF<sup>high</sup></em> MAIT cell interplay with different B cell subsets. In specific, predicted <em>TNF</em>-mediated activation was selectively directed to conventional switched memory B cells, which are deputed to high-affinity long-term memory.</p> <p><strong>Discussion:</strong> Overall, our results indicate that SARS-CoV-2 <em>BNT162b2</em> vaccination influences MAIT cell frequencies and their transcriptional effector profile with the potential to promote B cell activation. This work also provides a blueprint for the promising use of MAIT cells as cellular adjuvants in mRNA-based vaccines.</p>
Modeling of the Response to a Multiple Vaccination Schedule Using the Adjuvant Neisseria meningitidis Porin B
GEO Series GSE104337. Mus musculus. 30 samples. Type: Expression profiling by array.
Urine Metabolome Dynamics Discriminate Influenza Vaccination Response
<p>Overall global metabolomics data associated with publication</p>
Supplementary Information: The Mechanistic Modelling and Simulation of Vaccine-Adjuvant Induced Immune Responses
<p>Supplementary Information for Paul R. Buckley DPhil thesis.</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.