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1,315 results for “aberration”
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Secondary screening for 1mGyO familly).
GEO Series GSE211334. Mus musculus. 20 samples. Type: Genome variation profiling by genome tiling array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Primary screening for 1mGyL familly).
GEO Series GSE211324. Mus musculus. 16 samples. Type: Genome variation profiling by genome tiling array.
NMR based clinical metabolomics study revealed aberrant proline biosynthesis and mitochondrial dysfunction in patients of mild cognitive impairment
<p>The prevalence of type-2 diabetes mellitus (T2DM) is tremendously increasing in older population because of several reasons and studies have shown that such old-age T2DM patients have 50-65% higher risk of developing cognitive impairment and its progression towards mild cognitive impairment (MCI). The studies claim that in the majority of MCI patients, the diabetes selectively involves the brain and the condition is now considered as a neuroendocrine disorder, even referred to as type 3 diabetes (T3D). Impaired glucose metabolism and mitochondrial dysfunction in neurodegenerative diseases, particularly in MCI, is compelling. Therefore, clinical interest is emerging to understand the role of mitochondria in T2DM and T3D which may provide important insights into pathogenesis of such chronic diseases and may indeed provide a target for improved patient care. The present study, therefore, aims to compare the serum metabolic profiles of MCI patients with age and sex matched T2DM patients with respect to normal control (NC) subjects. The results revealed that abnormal glutamate-to-glutamine cycling and proline metabolism in MCI patients. Compared to T2DM patients, the elevated circulatory proline levels in MCI patients hinted towards abnormal mitochondrial functioning underlying cognitive impairment.</p>
Aberrant promoter methylation, expression and function of RASSF1A gene in a series of Italian parathyroid tumors
<p>Aberrant epigenetic features occurring in parathyroid tumors are key events involved in parathyroid tumorigenesis. They include DNA methylation, histone methylation, and non-coding RNAs. Ras Association Domain Family Protein1 Isoform A (RASSF1A) and Adenomatous Polyposis of Colon (APC) are frequently downregulated in human cancers and they have an emerging role in parathyroid neoplasms. Here, investigating the methylation of RASSF1A and APC promoters in a series of parathyroid adenomas from Italian patients with primary hyperparathyroidism (PAds, n=80), we reported that RASSF1A and APC promoter methylation occurred in about 90% of samples. Parathyroid carcinomas (PCas, n=9) displayed RASSF1A promoter methylation, while APC promoter was methylated only in 2 samples. Of note, RASSF1A promoter methylation negatively correlated with PAds tumor size. However, RASSF1A transcript and protein levels were reduced in PAds and PCas compared with parathyroid normal glands. Investigating the potential mechanism involved in RASSF1A promoter methylation, we found that DNA methyltransferases (DNMTs) activity was variable in PAds and inversely correlated with RASSF1A protein levels. In addition, the RASSF1A promoter methylation negatively correlated with long-non-coding Antisense Intronic Noncoding RASSF1A (ANRASSF1A) mRNA levels, excluding the involvement of ANRASSF1 in RASSF1A regulation. In HEK293A cells transfected with the calcium sensing receptor (CASR), loss of RASSF1A increased basal phosphorylated Extracellular signal-regulated kinase (pERK/ERK) levels blunting the CASR-induced increases. <br>In conclusion, RASSF1A and APC promoter methylation is a hallmark of parathyroid tumors; deregulation of DNMTs activity contributes to modulation of RASSF1A expression. Loss of RASSF1A may be involved in the tuning of ERK pathway in parathyroid tumors</p>
Aberrant lncRNA expression profiles in OSCC tissues compared with paired normal oral mucosa
GEO Series GSE84805. Homo sapiens. 12 samples. Type: Non-coding RNA profiling by array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Secondary screening for 1mGyH familly).
GEO Series GSE211305. Mus musculus. 16 samples. Type: Genome variation profiling by genome tiling array.
Determinants of response to BLU-222, a potent and highly selective CDK2 inhibitor, in CCNE1-aberrant ovarian and endometrial tumors
GEO Series GSE282041. Homo sapiens. 108 samples. Type: Expression profiling by high throughput sequencing.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 0.05mGy/day gamma-rays for 400 days (Primary screening for 0.05mGyC familly).
GEO Series GSE210429. Mus musculus. 16 samples. Type: Genome variation profiling by genome tiling array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 0.05mGy/day gamma-rays for 400 days (Primary screening for 0.05mGyN familly).
GEO Series GSE210471. Mus musculus. 18 samples. Type: Genome variation profiling by genome tiling array.
Crosstalk between histological alterations, oxidative stress and immune aberrations of the emerging PFOS alternative OBS in developing zebrafish
GEO Series GSE164074. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 0.05mGy/day gamma-rays for 400 days (Secondary screening for 0.05mGyI familly).
GEO Series GSE210458. Mus musculus. 18 samples. Type: Genome variation profiling by genome tiling array.
Detection of aberrant DNA methylation in acute myeloid leukemia samples compared to normal human monocytes
GEO Series GSE111915. Homo sapiens. 27 samples. Type: Methylation profiling by genome tiling array.
Aberrant Expression Profile of Circular RNAs in Human Lung Adenocarcinoma by Microarray Analysis
GEO Series GSE161348. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by array.
Two opposing gene expression patterns within ATRX aberrant neuroblastoma
GEO Series GSE226770. Homo sapiens. 34 samples. Type: Expression profiling by high throughput sequencing.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 0.05mGy/day gamma-rays for 400 days (Primary screening for 0.05mGyJ familly).
GEO Series GSE210459. Mus musculus. 16 samples. Type: Genome variation profiling by genome tiling array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 0.05mGy/day gamma-rays for 400 days (Primary screening for 0.05mGyK familly).
GEO Series GSE210462. Mus musculus. 18 samples. Type: Genome variation profiling by genome tiling array.
Analysis of transgenerational effects on DNA copy number aberrations in male mice exposed to continuous 1mGy/day gamma-rays for 400 days (Primary screening for 1mGyA familly).
GEO Series GSE211243. Mus musculus. 16 samples. Type: Genome variation profiling by genome tiling array.
Disruption of the epigenetic regulator BAP1 drives chromatin remodeling leading to the emergence of cells with breast cancer stem cell properties and aberrant glycosylation [RNAseq_2D]
GEO Series GSE271680. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Epigenetic changes cause aberrantly high expression of SOX11 leading to systemic sclerosis
GEO Series GSE268765. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by array.
Aberrant stabilized ETV4 expression cooperates with loss of p53 to promote invasive prostate carcinoma
GEO Series GSE130311. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.