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1,445 results for “Irradiation”
Active Cavity Radiometer Irradiance Monitor (ACRIM) II Total Solar Irradiance (TSI) aboard UARS in Native format
ACRIMII_TSI_UARS_NAT data are Active Cavity Radiometer Irradiance Monitor II (ACRIM II) Total Solar Irradiance (TSI) aboard the Upper Atmosphere Research Satellite (UARS) Data in Native (NAT) format. The ACRIMII_TSI_UARS_NAT data product consists of the Level 2 total solar irradiance in the form of daily means gathered by the ACRIM II instrument on the UARS satellite. The daily means are constructed from the shutter cycle results for each day. This data set is considered Version 2.
Effects of 5-Ion Beam Irradiation and Hindlimb Unloading on Metabolic Pathways in Plasma and Brain of Behaviorally Tested WAG/Rij Rats
A limitation of simulated space radiation studies is that radiation exposure is not the only environmental challenge astronauts face during missions. Therefore, we characterized behavioral and cognitive performance of male WAG/Rij rats 3 months after sham-irradiation or total body irradiation with a simplified 5-ion mixed beam exposure in the absence or presence of simulated weightlessness using hindlimb unloading (HU) alone. Six months following behavioral and cognitive testing or 9 months following sham-irradiation or total body irradiation, plasma and brain tissues (hippocampus and cortex) were processed to determine whether the behavioral and cognitive effects were associated with long-term alterations in metabolic pathways in plasma and brain. Sham HU, but not irradiated HU, rats were impaired in spatial habituation learning. Rats irradiated with 1.5 Gy showed increased depressive-like behaviors. This was seen in the absence but not presence of HU. Thus, HU has differential effects in sham-irradiated and irradiated animals and specific behavioral measures are associated with plasma levels of distinct metabolites 6 months later. The combined effects of HU and radiation on metabolic pathways in plasma and brain illustrate the complex interaction of environmental stressors and highlights the importance of assessing these interactions. This study derives results from the Open Field, Novel Object Recognition and Forced Swim Test behavior assays.
OrbView-2 SeaWiFS Global Binned Diffuse Attenuation Coefficient for Downwelling Irradiance (KD) Data, version R2022.0
The SeaWiFS instrument was launched by Orbital Sciences Corporation on the OrbView-2 (a.k.a. SeaStar) satellite in August 1997, and collected data from September 1997 until the end of mission in December 2010. SeaWiFS had 8 spectral bands from 412 to 865 nm. It collected global data at 4 km resolution, and local data (limited onboard storage and direct broadcast) at 1 km. The mission and sensor were optimized for ocean color measurements, with a local noon (descending) equator crossing time orbit, fore-and-aft tilt capability, full dynamic range, and low polarization sensitivity.
Sentinel-3A OLCI Level-3B Global Binned Earth-observation Reduced Resolution (ERR) Diffuse Attenuation Coefficient for Downwelling Irradiance (KD) - Near Real-time (NRT) Data, version R2022.0
The Ocean Biology DAAC produces near real-time (quicklook) products using the best-available combination of ancillary data from meteorological and ozone data. As such, the inputs and the calibration used are less than optimal. Quicklook products provide a snapshot of the data during a short time period within a single orbit.
Age and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime accumulation of cellular, particularly DNA, damage. However, during middle-age, the incidence begins to decelerate and, for many tumor sites, it actually decreases at sufficiently advanced ages. We investigated if the observed deceleration and potential decrease in incidence could be attributed to a decreased capacity of older hosts to support tumor progression, and whether HZE (high atomic number (Z), high energy (E)) radiation differentially modulates tumor progression in young versus middle-age hosts, issues relevant to estimating carcinogenesis risk for astronauts. Lewis lung carcinoma (LLC) cells were injected into syngeneic mice (143 and 551 days old), which were then subject to whole-body 56Fe irradiation (1GeV/amu). Three findings emerged: 1) among unirradiated animals, substantial inhibition of tumor progression and significantly decreased tumor growth rates were seen for middle-aged mice compared to young mice; 2) whole-body 56Fe irradiation (1GeV/amu) inhibited tumor progression in both young and in middle-aged mice (with greater suppression seen in case of young animals), with little effect on tumor growth rates; and 3) 56Fe irradiation (1GeV/amu) suppressed tumor progression in young mice, to a degree not significantly different than transiting from young to middle-aged. Thus, 56Fe irradiation (1GeV/amu) acted similar to aging with respect to tumor progression. We further investigated the molecular underpinnings driving the radiation modulation of tumor dynamics in young and middle-aged mice. Through global gene expression analysis, the key players, FASN, AKT1, and the CXCL12/CXCR4 complex, were determined to be contributory. In sum, these findings demonstrate a reduced capacity of middle-aged hosts to support the progression phase of carcinogenesis and identify molecular factors contributory to HZE radiation modulation of tumor progression as a function of age. For genome-wide expression profiling of tumor tissue, Mouse WG-6 BeadArray chips (Illumina, San Diego, CA) were used. Total RNA was amplified with the Ambion Illumina TotalPrep Amplification Kit (Ambion, Austin, TX) and labeled from all replicate biological samples for each condition. The number of tumor sample replicates used from each condition is as follows: 10 samples from young unirradiated mice, 8 samples from young irradiated mice, 7 samples from middle-aged unirradiated mice, 5 samples from middle-aged irradiated mice. Total RNA was isolated and purified using Trizol (Invitrogen) or RNeasy (Qiagen), quantified and qualified using Agilent Bioanalyzer (Agilent) and samples were deemed suitable for amplification and hybridization if they had O.D. 260/280 = 1.7 - 2.1, 28s/18s = 2:1, RIN (RNA integrity number) >7. Total RNA of 500ng per sample was amplified using Ambion TotalPrep (Ambion), and 1.5ug of the product was loaded onto the chips. Following hybridization at 55C, the chips were washed and then scanned using the Illumina iScan (Illumina), and the data were analyzed using GenomeStudio (Illumina). Data were first analyzed for gene expression and then culled for present genes (genes that meet the criteria of detection p-value < 0.05). Expression above background was included in an expressed genes working data set for further analyses. Rank variant normalization was applied to the data before extensive analysis. Differential gene expression analysis was used to compare to the reference group, young unirradiated mice, and genes were then evaluated and validated.
UARS Solar-Stellar Irradiance Comparison Experiment (SOLSTICE) Level 3BS V018 (UARSO3BS) at GES DISC
The Solar-Stellar Irradiance Comparison Experiment (SOLSTICE) Level 3BS data product consists of daily, 1 nm resolution, solar spectral irradiances and selected solar parameters. The instrument was a three-channel ultraviolet spectrometer that measured the magnitude of solar and spectral irradiances in the wavelength range from 119 to 420 nm. The design of the instrument allowed for observations of both the sun and bright blue stars, whose spectra is assumed to be constant. SOLSTICE was flown on NASA's Upper Atmosphere Research Satellite (UARS) and designed to measure the full disk solar irradiance with high precision and accuracy to follow short-term (minutes to hours), intermediate-term (days to weeks), and long-term (11 year sunspot, and 22 year solar magnetic field cycles) variations in the solar output. The SORCE Level 3BS data were processed with the version 18 algorithm. The SOLSTICE Level 3BS data consists of 1 granule per day. The data are normalized to an earth-sun distance of 1 AU, and instrument degradation have been applied to the data. Included with the primary solar spectral irradiance values are daily average integrated intensities of Lyman alpha (121.6 nm), O-I (130.4 nm), C-IV (154.8 nm) and C-I (156.1 and 165.6 nm), and core-wing ratios of Mg-II (280.0 nm) and Ca-II (393.3 nm), as well as Carrington latitude and longitudes. The data files are available in a binary record oriented format.
Gene expression profiling in human fibroblast after low-LET irradiation
Exposure to radiation provokes cellular responses controlled in part by gene expression networks. MicroRNAs (miRNAs) are small non-coding RNAs which mostly regulate gene expression by degrading the messages or inhibiting translation. Here we investigated changes in miRNA expression patterns after low (0.1 Gy) and high (2.0 Gy) doses of X-ray in human fibroblasts. At early (0.5 h) and late (6 and 24 h) time points irradiation caused qualitative and quantitative differences in the down-regulation of miRNA levels including miR-92b 137 660 and 656. A transient up-regulation of miRNAs was observed after 2 h post-irradiation following high doses of radiation including miR-558 and 662. MicroRNA levels were inversely correlated with targets from mRNA and proteomic profiling after 2.0 Gy of radiation. MicroRNAs miR-579 608 548-3p and 585 are noted for targeting genes involved in radioresponsive mechanisms such as cell cycle checkpoint and apoptosis. We suggest here a model in which miRNAs may act as hub regulators of specific cellular responses immediately down-regulated so as to stimulate DNA repair mechanisms followed by up-regulation involved in suppressing apoptosis for cell survival. Taken together miRNAs may mediate signaling pathways in sequential fashion in response to radiation and may serve as biodosimetric markers of radiation exposure. Overall design: The gene expression patterns in human fibroblasts after 2.0 Gy of low-LET radiation was determined at 2 and 24 hrs post-irradiation time in technical triplicates. Control non-irradiated samples were also prepared in triplicates.
Terra MODIS Global Mapped Diffuse Attenuation Coefficient for Downwelling Irradiance (KD) - Near Real Time (NRT) Data, version R2022.0
The Ocean Biology DAAC produces near real-time (quicklook) products using the best-available combination of ancillary data from meteorological and ozone data. As such, the inputs and the calibration used are less than optimal. Quicklook products provide a snapshot of the data during a short time period within a single orbit.
Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions. 129S2 K-rasLA1 mice were either irradiated with an acute (1.0Gy x1; n = 15) or fractionated (0.2Gy x5; n=13) dose of 1.0Gy 56Fe- particles or left unirradiated (n=13). Animals were euthanized 70 days post-irradiation and RNA was extracted from the whole left lung of each animal.
NOAA-21 VIIRS Global Mapped Diffuse Attenuation Coefficient for Downwelling Irradiance (KD) - Near Real Time (NRT) Data, version R2022.0
The Ocean Biology DAAC produces near real-time (quicklook) products using the best-available combination of ancillary data from meteorological and ozone data. As such, the inputs and the calibration used are less than optimal. Quicklook products provide a snapshot of the data during a short time period within a single orbit.
Proton Irradiation Impacts Age Driven Modulations of Cancer Progression Influenced by Immune System Transcriptome Modifications from Splenic Tissue
Age plays a crucial role in the interplay between tumor and host; with further perturbations induced by irradiation. Proton irradiation on tumors induces biological modulations including inhibition of angiogenic and immune factors critical to ''hallmark'' processes impacting tumor development, in addition to physical targeting advantages. These advantages have provided promising results for proton therapy in cancer. Additionally, protons have implications for carcinogenesis risk of space travel (due to the high proportion of high energy protons in space radiation). Through a systems biology approach, we investigated how host tissue (i.e. splenic tissue) of tumor-bearing mice is altered with age, with or without whole-body proton exposure. Transcriptome analysis was performed on splenic tissue from adolescent (68 day) versus old (736 day) C57BL/6 male mice injected with Lewis lung carcinoma cells with or without three fractionations of 0.5Gy (1GeV) proton irradiation. Global transcriptome analysis indicated that proton irradiation of adolescent hosts caused significant signaling changes within splenic tissues that support carcinogenesis within the mice, as compared to old subjects. Increases in cell cycling and immunosuppression in irradiated adolescent hosts with CDK2, MCM7, CD74, and RUVBL2 as the key players were involved in the regulatory changes in host environment response (i.e. spleen). These results suggest a significant biological component to proton irradiation, operative through host age, that would indicate a modulation of host's ability to support carcinogenesis in adolescence and the bestowal of resistance to immunosuppression, carcinogenesis, and genetic perturbation by old age.
Nimbus-7 Total Solar Irradiance Data in Native Format
The NIMBUS7_ERB_Ch10C_TSI_NAT data set is the Nimbus-7 Channel 10C (Ch10C) Total Solar Irradiance (TSI) aboard the Earth Radiation Budget (ERB) satellite Data in Native (NAT) format.The Nimbus 7 research-and-development satellite served as a stabilized, earth-oriented platform for the testing of advanced systems for sensing and collecting data in the pollution, oceanographic and meteorological disciplines. The polar-orbiting spacecraft consisted of three major structures: (1) a hollow torus-shaped sensor mount, (2) solar paddles, and (3) a control housing unit that was connected to the sensor mount by a tripod truss structure.
Sentinel-3B OLCI Level-3B Global Binned Earth-observation Reduced Resolution (ERR) Diffuse Attenuation Coefficient for Downwelling Irradiance (KD) - Near Real-time (NRT) Data, version R2022.0
The Ocean Biology DAAC produces near real-time (quicklook) products using the best-available combination of ancillary data from meteorological and ozone data. As such, the inputs and the calibration used are less than optimal. Quicklook products provide a snapshot of the data during a short time period within a single orbit.
HUVEC Gene Expression of Irradiated Human Umbilical Vein Endothelial Cells
GEO Series GSE108723. Homo sapiens. 6 samples. Type: Expression profiling by array.
Biological characteristics of gene expression features in pancreatic cancer cell induced by proton and x-ray irradiation III
GEO Series GSE107442. Homo sapiens. 10 samples. Type: Expression profiling by array.
UV irradiation remodels the specificity landscape of transcription factors
GEO Series GSE223023. Arabidopsis thaliana; synthetic construct; Mus musculus; Homo sapiens. 46 samples. Type: Other.
UV irradiation remodels the specificity landscape of transcription factors [86688_Proteins]
GEO Series GSE223022. Homo sapiens; synthetic construct. 4 samples. Type: Other.
Single cell sequencing analysis of control, photon- and proton- irradiated salivary gland organoids at day 11
GEO Series GSE253048. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Global gene expression in Head and neck squamous carcinoma (KB) cells treated with the combination of 2-DG + 6-AN followed by irradiation (2-Gy)
GEO Series GSE23989. Homo sapiens. 4 samples. Type: Expression profiling by array.
Single cell RNA-Seq of blood cells in an irradiated patient
GEO Series GSE194104. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.