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2,709 results for “Mouse Model”
Cerebellar Transcriptomic Analysis in a Chronic Plus Binge Mouse Model of Alcohol Use Disorders Demonstrate Ethanol Induced Neuroinflammation and Altered Glial Gene Expression
GEO Series GSE222445. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA and mRNA integrated transcriptional analysis in a Cx30-/- mouse model of non-syndromic hearing loss and deafness [mRNA]
GEO Series GSE151367. Mus musculus. 8 samples. Type: Expression profiling by array.
Transcriptional profile of the hippocampus from a polygenic obese mouse model compared to a reference mouse line
GEO Series GSE280980. Mus musculus. 10 samples. Type: Expression profiling by array.
Ribo– RNA-seq of psoriasis mouse model
GEO Series GSE248678. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing.
Effects of human adipose tissue-derived and umbilical cord tissue-derived mesenchymal stem cells in a dextran sulfate sodium-induced mouse model
GEO Series GSE137173. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive circRNA expression profile and construction of circRNAs-related ceRNA network in a mouse model of autism
GEO Series GSE163904. Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Developmental Deficits of MGE-derived Interneurons in the Cntnap2 Knockout Mouse Model of Autism Spectrum Disorder
GEO Series GSE222383. Mus musculus. 1 samples. Type: Other.
Single cell lineage tracing of pulmonary endothelial cells in mouse model of Hereditary Hemorrhagic Telangiectasia 2
GEO Series GSE269174. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Use of mice defective in interferon signaling to distinguish between primary and secondary pathological pathways in a mouse model of neuronal forms of Gaucher disease
GEO Series GSE150266. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Histopathology of the tongue in a mouse model of oculopharyngeal muscular dystrophy reveals progressive PABPN1 deposition associated with muscle wasting.
GEO Series GSE263433. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
RNA and miRNA sequencing of an IGF1R transgenic mouse model of lung cancer
GEO Series GSE109629. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Analysis of antibody production in a mouse model of Sjögren’s Syndrome
GEO Series GSE62176. Mus musculus; Rattus norvegicus; Homo sapiens. 74 samples. Type: Protein profiling by protein array.
Gene expression response in mouse model of inflammatory bowel disease to ionizing radiation
GEO Series GSE114142. Mus musculus. 20 samples. Type: Expression profiling by array.
Cardiac Myoediting Attenuates Cardiac Abnormalities in Human and Mouse Models of Duchenne Muscular Dystrophy
GEO Series GSE169190. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Molecular profiling of rhabdoid tumors in a Smarcb1-deficient mouse model
GEO Series GSE94082. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Tractable mouse TNBC models capture the heterogeneous tumor immune microenvironment and adaptation to PD-L1 blockade
GEO Series GSE292146. Mus musculus. 38 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profile at single cell level of non-malignant cells in KRAS syngeneic mouse tumor models
GEO Series GSE231742. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: Examining the effects of the histone methyltransferase inhibitor BIX-01294 on histone modifications and gene expression in both a clinical population and mouse models
Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA and H3K9me2 levels are elevated in postmortem brain and peripheral blood cells of persons with schizophrenia. Moreover, this epigenomic state likely contributes to the disease, as HMT levels correlate with clinical symptomatology. This manuscript sought to establish the potential therapeutic value of the HMT inhibitor BIX-01294 (BIX). Human peripheral mononuclear cells (PBMC) from 24 individuals with schizophrenia and 24 healthy individuals were cultured in the presence of BIX (5uM or 10uM). Mice were given once daily intraperitoneal injections of BIX (0.5 or 1mg/kg) for one week. Cultured cells, mouse cortex, or striatum was harvested, RNA extracted and RT-PCR conducted for several schizophrenia candidate genes: IL-6, Gad1, Nanog, KLF4, Reln, and Bdnf9a. Total H3K9me2 levels were measured using western blot while H3K9me2 binding to selected genes of interest was conducted using chromatin immunoprecipitation (ChIP). Neuronal subtype-specific BDNF conditional knockdown was conducted using the cre/lox system of mutant animals. Treatment with BIX decreased H3K9me2 and increased selected mRNA levels in cultured PBMCs from both normal controls and participants with schizophrenia. In mice, peripheral administration of BIX decreased cortical H3K9me2 levels and increased schizophrenia candidate gene expression. In BDNF conditional knockdown animals, BIX administration was able to significantly rescue Bdnf9a mRNA levels in ChAT and D1 but not D2 Bdnf conditional knockdown mice. The results presented in this manuscript demonstrate a potential for further research into the clinical effectiveness of histone modifying pharmacology in the treatment of schizophrenia.
Dataset related to article "ECoG spiking activity and signal dimension are early predictive measures of epileptogenesis in a translational mouse model of traumatic brain injury"
<p>Excel folder with raw data related to the paper 10.1016/j.nbd.2023.106251</p>
Figure 1 from: Almudaris SA, Gatea FK (2024) Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings. Pharmacia 71: 1-14. https://doi.org/10.3897/pharmacia.71.e114753
Figure 1 Flow chart of the study.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.