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1,395
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Dataset results
1,395 results for “Tumor immunity”
IL-21-αHSA combined with TIGIT blockade induces an effective anti-tumor immune response
GEO Series GSE185727. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
E2F4/SETD1A axis-mediated METTL3 methylation promotes tumor immune evasion through impeding endogenous retroelements expression
GEO Series GSE296929. Homo sapiens. 18 samples. Type: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
G9a Epigenetically Suppresses CXCL10 Expression and Inhibits Anti-tumor Immunity in Hepatocellular Carcinoma
GEO Series GSE298822. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Lymphatic-derived 25-hydroxycholesterol promotes immunity in melanoma by inhibiting PPAR-γ in tumor associated macrophages and monocytes
GEO Series GSE242026. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
TMEM16F Phospholipid Scramblase Regulates Tumorigenesis by Modulating the Tumor Immune Microenvironment
GEO Series GSE293421. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Host MTDH orchestrates liver lipid metabolism and CD8+ T cells to suppress antitumor immunity [Tumor]
GEO Series GSE288416. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
TOX drives TH1 CD4+ T cell effector function, anti-tumor immunity, and pathogenicity in autoimmune diseases
GEO Series GSE317904. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Expansion of Tumor-Infiltrating CD8+ T Cell Clonotypes Occurs in the Spleen in Response to Immune Checkpoint Blockade
GEO Series GSE270050. Mus musculus. 29 samples. Type: Expression profiling by high throughput sequencing; Other.
Prostaglandin E2-EP4 signaling shapes immunosuppressive tumor microenvironment in human tumors by suppressing bioenergetics and ribosome biogenesis in infiltrating immune cells [scRNA-seq]
GEO Series GSE242271. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to article "Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy"
<p>This record contains data related to article “Inhibition of tumor-associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti-PD-1 therapy". </p> <p>A considerable proportion of cancer patients are resistant or only partially responsive to immune checkpoint blockade immunotherapy. Tumor-Associated Macrophages (TAMs) infiltrating the tumor stroma suppress the adaptive immune responses and, hence, promote tumor immune evasion. Depletion of TAMs or modulation of their protumoral functions is actively pursued, with the purpose of relieving this state of immunesuppression. We previously reported that trabectedin, a registered antitumor compound, selectively reduces monocytes and TAMs in treated tumors. However, its putative effects on the adaptive immunity are still unclear. In this study, we investigated whether treatment of tumor-bearing mice with trabectedin modulates the presence and functional activity of T-lymphocytes. In treated tumors, there was a significant upregulation of T cell-associated genes, including CD3, CD8, perforin, granzyme B, and IFN-responsive genes (MX1, CXCL10, and PD-1), indicating that T lymphocytes were activated after treatment. Notably, the mRNA levels of the Pdcd1 gene, coding for PD-1, were strongly increased. Using a fibrosarcoma model poorly responsive to PD-1-immunotherapy, treatment with trabectedin prior to anti-PD-1 resulted in improved antitumor efficacy. In conclusion, pretreatment with trabectedin enhances the therapeutic response to checkpoint inhibitor-based immunotherapy. These findings provide a good rational for the combination of trabectedin with immunotherapy regimens.</p> <p> </p>
Single-cell spatial profiling of small cell lung cancer suggests clinical outcome related tumor heterogeneity and immune colony niche
<p>High-dimension processed tif images of the publication "<strong>Spatial evolution and colony landscape of small cell lung cancer</strong>". The code used to produce the results of this study is available at <a href="https://github.com/ wangjun-hub/CODEX_SCLC">https://github.com/ wangjun-hub/CODEX_SCLC</a>.</p>
Viral-directed augmentation of Kupffer cell cross-presentation provokes anti-tumor immunity against liver metastasis
GEO Series GSE284315. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
GFPT2 knockdown effects on the tumor immune microenvironment though scRNA-seq
GEO Series GSE259244. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
DCBLD2 promotes perivascular anti-tumor immune deprivation by educating SPP1+ pro-angiogenic macrophages
GEO Series GSE271377. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Mal2 drives immune evasion by reducing antigen presentation on tumor cells
GEO Series GSE144099. Mus musculus. 3 samples. Type: Expression profiling by high throughput sequencing.
Immune recovery in tumor microenvironment of TP53-mutated AML following venetoclax combination therapy
GEO Series GSE306339. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Targeting LRRC25 enhances antitumor immunity of tumor-associated macrophages through CD8+ T cells [scRNA-seq]
GEO Series GSE264446. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation
GEO Series GSE171158. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Regulatory T cells converted from T helper 1 cells in tumors suppress cancer immunity via CD39
GEO Series GSE283943. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Trained immunity-promoting nanobiologics suppress tumor growth and potentiate checkpoint blockade immunotherapy
GEO Series GSE126793. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.