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2,709 results for “Mouse Model”
Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome
<p>Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein, <em>retinoic acid induced 1</em> (<em>RAI1</em>), causes Smith–Magenis syndrome (SMS). SMS is a syndromic ASD associated with intellectual disability, autistic features, maladaptive behaviors, overt seizures, and abnormal electroencephalogram (EEG) patterns. The molecular and neural mechanisms underlying abnormal brain activity in SMS remain unclear. Here we show that panneural <em>Rai1</em> deletions in mice result in increased seizure susceptibility and prolonged hippocampal seizure duration in vivo and increased dentate gyrus population spikes ex vivo. Brain-wide mapping of neuronal activity pinpointed selective cell types within the limbic system, including the hippocampal dentate gyrus granule cells (dGCs) that are hyperactivated by chemoconvulsant administration or sensory experience in <em>Rai1</em>-deficient brains. Deletion of <em>Rai1</em> from glutamatergic neurons, but not from gamma-aminobutyric acidergic (GABAergic) neurons, was responsible for increased seizure susceptibility. Deleting <em>Rai1</em> from the <em>Emx1<sup>Cre</sup></em>-lineage glutamatergic neurons resulted in abnormal dGC properties, including increased excitatory synaptic transmission and increased intrinsic excitability. Our work uncovers the mechanism of neuronal hyperexcitability in SMS by identifying Rai1 as a negative regulator of dGC intrinsic and synaptic excitability.</p>
Perimenopausal and menopausal mammary glands in a 4-vinylcyclohexene diepoxide mouse model
<p><span>As both perimenopausal and menopausal periods are recognized critical windows of susceptibility for breast carcinogenesis, development of a physiologically relevant model has been warranted. The traditional ovariectomy model causes instant removal of the entire hormonal repertoire produced by the ovary, which does not accurately approximate human natural menopause with gradual transition. Here, we characterized the mammary glands of 4-vinylcyclohexene diepoxide (VCD)-treated animals at different time points, revealing that the model can provide the mammary glands with both perimenopausal and menopausal states. The perimenopausal gland showed moderate regression in ductal structure with no responsiveness to external hormones, while the menopausal gland showed severe regression with hypersensitivity to hormones. Leveraging the findings on the VCD model, effects of a major endocrine disruptor (polybrominated diphenyl ethers, PBDEs) on the mammary gland were examined during and after menopausal transition, with the two exposure modes; low-dose, chronic (environmental) and high-dose, subacute (experimental). All conditions of PBDE exposure did not augment or compromise the macroscopic ductal reorganization resulting from menopausal transition and/or hormonal treatments. Single-cell RNA sequencing revealed that the experimental PBDE exposure during the post-menopausal period caused specific transcriptomic changes in the non-epithelial compartment such as <em>Errfi1</em> upregulation in fibroblasts. The environmental PBDE exposure resulted in similar transcriptomic changes to a lesser extent. In summary, the VCD mouse model provides both perimenopausal and menopausal windows of susceptibility for the breast cancer research community. PBDEs, including all tested models, may affect the post-menopausal gland including impacts on the non-epithelial compartments.</span></p>
Bulk RNA-seq count matrices from manuscript: "Therapeutic efficacy of intracerebral hematopoietic stem cell gene therapy in an Alzheimer's disease mouse model"
<p>Gene expression profile of microglia-like cells in the central nervous system (CNS) after transplantation of hematopoietic stem/progenitor cells (HSPC). </p> <p>Different cell subsets and delivery routes are tested to induce a robust and exclusive engraftment of HSPCs and their progeny in the CNS of mice transplant recipients.</p>
Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model
Open the record for dataset details and reuse information.
Alterations ion channel expression in prefrontal cortex of a mouse model of schizophrenia
<p>Maternal immune activation (MIA) and juvenile social isolation (SI) are two most prevalent and widely accepted environmental insults that could increase the propensity of psychiatric illnesses. Using a two-hit model, we examined the impact of these two factors on expressions of voltage-gated sodium (Nav) and small conductance calcium-activated potassium (SK) channels in the prefrontal cortex (PFC). We found that MIA-SI significantly increased the expression level of Nav1.2 and SK3 channels that contribute to the somatodendritic potential and the mAHP, respectively. </p>
Data from: Discovery of potential urine-accessible metabolite biomarkers associated with muscle disease and corticosteroid response in the mdx mouse model for Duchenne
Urine is increasingly being considered as a source of biomarker development in Duchenne Muscular Dystrophy (DMD), a severe, life-limiting disorder that affects approximately 1 in 4500 boys. In this study, we considered the mdx mice—a murine model of DMD—to discover biomarkers of disease, as well as pharmacodynamic biomarkers responsive to prednisolone, a corticosteroid commonly used to treat DMD. Longitudinal urine samples were analyzed from male age-matched mdx and wild-type mice randomized to prednisolone or vehicle control via liquid chromatography tandem mass spectrometry. A large number of metabolites (869 out of 6,334) were found to be significantly different between mdx and wild-type mice at baseline (Bonferroni-adjusted p-value < 0.05), thus being associated with disease status. These included a metabolite with m/z = 357 and creatine, which were also reported in a previous human study looking at serum. Novel observations in this study included peaks identified as biliverdin and hypusine. These four metabolites were significantly higher at baseline in the urine of mdx mice compared to wild-type, and significantly changed their levels over time after baseline. Creatine and biliverdin levels were also different between treated and control groups, but for creatine this may have been driven by an imbalance at baseline. In conclusion, our study reports a number of biomarkers, both known and novel, which may be related to either the mechanisms of muscle injury in DMD or prednisolone treatment.
IMC dataset for CCA mouse model study
<p>Imaging Mass Cytometry files acquired at Johns Hopkins Mass Cytometry Facility</p> <p>Contents of zipped file, "Raw_MCDFiles_Manuscript.zip":</p> <ol> <li>Raw MCD files for cholangiocarcinoma mouse model study</li> <li>Metadata for ROIs</li> </ol> <p>Also included, "IMC - Mouse Panel": panel of antibodies used</p> <p>Notes:</p> <ul> <li>ROI D2 was split into two ROIs: D2-split1 and D2-split2</li> <li>Non-experimental ROIs are labelled as either “null” or “Energy Test”</li> </ul>
Developing and Treating a Mouse Model of Acute Myeloid Leukemia Using Tissue Samples From Younger Patients With Acute Myeloid Leukemia
ClinicalTrials.gov study NCT01576185. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Sampling of Human Microbiota in Order to Test, on a Mouse Model, Individualized Intervention Strategies During Aging
ClinicalTrials.gov study NCT04753580. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer
ClinicalTrials.gov study NCT00897468. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Validation of a Mouse Model of Pancreatic Carcinogenesis
ClinicalTrials.gov study NCT01103128. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A mouse model with high clonal barcode diversity for joint lineage, transcriptomic, and epigenomic profiling in single cells [10X scRNA-seq data]
GEO Series GSE221501. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Expression profiles of genetically engineered mouse model tumors (GNA11 Q209L and GNA11 Q209L Bap1 KO)
GEO Series GSE97223. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
Long-term caffeine treatment of Alzheimer mouse models ameliorates behavioural deficits and neuron loss and promotes cellular and molecular markers of neurogenesis
GEO Series GSE183323. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Systematic Phenotyping and Characterization of the 5xFAD mouse model of Alzheimer’s Disease
GEO Series GSE168137. Mus musculus. 192 samples. Type: Expression profiling by high throughput sequencing.
Spatial single cell transcriptomic analysis of a lineage-traceable mouse model of DICER1 Syndrome informs tumor developmental hierarchy [Xenium]
GEO Series GSE289001. Mus musculus. 72 samples. Type: Other.
Natural and molecular history of prolactinoma: insights from a Prlr -/- mouse model
GEO Series GSE100334. Mus musculus. 14 samples. Type: Expression profiling by array.
The effects of H3.3K27M mutation on developing mouse brain and cooperation with Trp53 on enhancing tumorigenesis in the genetic model of H3.3K27M [Exome-Seq]
GEO Series GSE120883. Mus musculus. 16 samples. Type: Genome variation profiling by high throughput sequencing.
Immunoediting of the cancer genome during tumor progression and activation of PD-1/PD-L1 axis in a mouse model of carcinoma
GEO Series GSE93018. Mus musculus. 34 samples. Type: Genome variation profiling by SNP array; Expression profiling by high throughput sequencing.
Upregulation of extracellular proteins in a mouse model of Alzheimer’s Disease
GEO Series GSE223417. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.