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2,884
datasets available to search
ShareScore release 0.9.0
Dataset results
2,884 results for “cancer resistance”
Downregulation of TAB182 promotes cancer stem-like cell properties and therapeutic resistance in triple-negative breast cancer cells
GEO Series GSE200038. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
17beta-estradiol (E2)-regulated gene expression across time in estrogen-dependent and estrogen deprivation-resistant MCF-7-derived breast cancer cell lines.
GEO Series GSE29917. Homo sapiens. 118 samples. Type: Expression profiling by array.
Human breast cancer cells: parental v.s lapatinib-resistant clone
GEO Series GSE51889. Homo sapiens. 4 samples. Type: Expression profiling by array.
Single cell lineage tracing reveals clonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer
GEO Series GSE228154. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer
GEO Series GSE133696. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
PELP1/SRC-3-dependent regulation of metabolic kinases drives therapy resistant ER+ breast cancer [3D]
GEO Series GSE159275. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Inosine Monophosphate Dehydrogenase 2 (IMPDH2) Modulates Response to Therapy and Chemo-Resistance in Triple Negative Breast Cancer
GEO Series GSE264197. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
MYOD1L122R induces cancer stem cell pathways to impart chemotherapy and radiation-resistance in aggressive rhabdomyosarcoma [RNAseq_Ruch2oe]
GEO Series GSE274636. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
5-hydroxymethylcytosine marks promoters in colon that resist hypermethylation in cancer
GEO Series GSE47592. Homo sapiens. 137 samples. Type: Expression profiling by array; Methylation profiling by array; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Temporal dynamic reorganization of 3D chromatin in hormone-induced breast cancer and endocrine resistance [T47D]
GEO Series GSE119890. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
GEO Series GSE87448. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
tRNA-derived small non-coding RNAs (tDRs) as novel predictive biomarkers for trastuzumab-resistant breast cancer.
GEO Series GSE107473. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Proteogenomic analysis reveals a compendium of therapeutic targets for treatment-resistant subtypes of locally advanced cervical cancers
GEO Series GSE279998. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
KIR Polymorphism is Associated with Primary Resistance to PD-1 Blockade in Lung Cancer
GEO Series GSE111414. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Targeting FOXA1-mediated repression of TGF-β signaling suppresses castration-resistant prostate cancer progression [microarray]
GEO Series GSE119758. Homo sapiens. 5 samples. Type: Expression profiling by array.
NSD2 targeting reverses lineage plasticity and drug resistance in advanced prostate cancer [snATAC-seq and multiome snATAC-seq]
GEO Series GSE237196. Mus musculus. 9 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Data from: Higher insulin resistance & adiposity in post-menopausal women with breast cancer treated with aromatase inhibitors
Context: Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy in post-menopausal breast cancer. Objective: We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer. Design: Case-control study Setting: University teaching hospital Participants: 20 post-menopausal breast cancer patients, treated with aromatase inhibitor and 20 age-matched controls. Main outcome measures: Primary outcome measure was insulin sensitivity index – Matsuda, derived from a 75g oral glucose tolerance test. Body composition was assessed by DEXA and subcutaneous adipose tissue biopsies obtained for assessment of mRNA transcript levels. Data are mean ± SEM (inhibitor vs controls). Results: Aromatase inhibitor therapy was associated with significantly lower insulin sensitivity (5.15 ± 0.45 vs. 6.80 ± 0.64, P = 0.041), higher peak insulin concentration following OGTT (693.4 ± 78.6 vs. 527.6 ± 85.5 pmol/L, P = 0.035), greater percentage body fat (38.4 ± 1.0 vs. 34.6 ± 1.3 %, P = 0.026), and higher plasma leptin concentration (23.5 ± 2.8 vs. 15.5 ± 2.3 ng/mL, P = 0.035). Conclusions: Women who received aromatase inhibitors for post-menopausal breast cancer have greater percentage body fat and insulin resistance compared to controls with no history of breast cancer.
Figure 1 from: Hamed RA, Talib WH (2024) Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study. Pharmacia 71: 1-19. https://doi.org/10.3897/pharmacia.71.e117997
Figure 1 Shows the treatment groups for the in vivo study with the subjected doses.
Prospective National Cohort Evaluating Predictive Biomarkers of Resistance to Immunotherapy in Patients With MSI/dMMR Metastatic Colorectal Cancer (CORESIM)
ClinicalTrials.gov study NCT06353854. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A QT/QTc and Multi-Dose Pharmacokinetic Study of Abiraterone Acetate Plus Prednisone in Patients With Metastatic Castration-Resistant Prostate Cancer
ClinicalTrials.gov study NCT00910754. IPD Sharing: Not stated. Countries: 2. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.