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1,337
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Dataset results
1,337 results for “inflammatory disease”
REV-ERBα regulates regulatory T cell function in inflammatory bowel disease [CUT&RUN]
GEO Series GSE225202. Mus musculus. 29 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Patients with Activated B-cell-like Diffuse Large B-cell Lymphoma (ABC DLBCL) in high and low infectious disease areas have different inflammatory gene signatures
GEO Series GSE34339. Homo sapiens. 6 samples. Type: Expression profiling by array.
FTO SUMOylation regulates the differentiation of bone marrow mesenchymal stromal cells in Inflammatory Bowel Disease-Induced Bone Loss
GEO Series GSE298548. Mus musculus. 6 samples. Type: Methylation profiling by high throughput sequencing.
IL13 and CCL2 Drive Disease in an Inflammatory Subset of Scleroderma
GEO Series GSE24410. Homo sapiens; Mus musculus. 44 samples. Type: Expression profiling by array.
BMI1 Maintains the Regulatory T cell Epigenomic Landscape to Prevent Inflammatory Bowel Disease (Microarray)
GEO Series GSE171189. Mus musculus. 4 samples. Type: Expression profiling by array.
SWI/SNF chromatin-remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cells migration [CUT&Tag]
GEO Series GSE267296. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
REV-ERBα regulates regulatory T cell function in inflammatory bowel disease
GEO Series GSE225203. Mus musculus. 35 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Dataset related to article "Psychological Characteristics of Inflammatory Bowel Disease Patients: A Comparison Between Active and Nonactive Patients."
<p>BACKGROUND AND AIMS:</p> <p>The role of new psychological factors such as psychopathological patterns and defense mechanisms in the care of inflammatory bowel disease (IBD) has been poorly investigated. We aimed to assess the psychological characteristics and defense mechanisms of IBD patients.</p> <p>METHODS:</p> <p>This was a single-center, observational, cross-sectional study. Consecutive adult IBD patients were enrolled and stratified according to disease activity. Sociodemographic and clinical data were collected, and validated questionnaires (Symptom Checklist-90-R [SCL-90-R]) for psychological distress, Defense Mechanism Inventory (DMI) for psychological defense mechanisms, and Inflammatory Bowel Disease Questionnaire (IBDQ) for quality of life (QoL) were administered.</p> <p>RESULTS:</p> <p>Two hundred one patients were enrolled: 101 in remission and 100 with active disease. The mean score for IBDQ was below the cutoff level (156.8 ± 37.8), with a significantly greater impairment of QoL in subjects with flares (136.5 vs 177.5, P < 0.001). Lower scores were associated with female gender. No patients had psychological scores above the cutoff for normality. Statistically higher SCL-90-R scores were found in active patients for obsessive-compulsive disorder (P = 0.026), depression (P = 0.013), anxiety (P = 0.013), phobic anxiety (P = 0.002), psychoticism (P = 0.007), global severity index (GSI) (P = 0.005) and positive symptom total (PST) (P = 0.001). A significantly increased probability of higher global indexes was associated with Crohn's disease and disease flares. None of the defensive Defense Mechanism Inventory (DMI) styles resulted above the cutoff in our cohort.</p> <p>CONCLUSIONS:</p> <p>Further data are needed to demonstrate the potential key role of psychological intervention in the therapeutic strategies utilized for IBD patients, and the identification of specific psychological patterns based on the patients profile is necessary to optimize psychological intervention.</p>
scRNA-seq data for "Bacteroides fragilis toxin suppresses METTL3-Mediated m6A modification in macrophage to promote inflammatory bowel disease"
Open the record for dataset details and reuse information.
Dataset related to article: "Full Interchangeability in Regard to Immunogenicity Between the Infliximab Reference Biologic and Biosimilars CT-P13 and SB2 in Inflammatory Bowel Disease"
<p>This record contains raw data related to article "Full Interchangeability in Regard to Immunogenicity Between the Infliximab Reference Biologic and Biosimilars CT-P13 and SB2 in Inflammatory Bowel Disease"</p> <p>Infliximab (IFX) biosimilars CT-P13 and SB2 have comparable efficacy, safety, and immunogenicity to the originator Remicade (RMC). However, concerns about cross-switching patients between the 3 brands were raised in the absence of cross reactivity data between them. We aimed to determine whether antibodies to infliximab (ATI) in inflammatory bowel disease (IBD) patients cross-react with RMC, CT-P13, and SB2.</p> <p>Methods:</p> <p>Based on previous ATI status, samples from 34 patients participating in the BIOSIM01 study (13 RMC, 9 CT-P13, and 12 switchers) were selected. Patients were treated with either RMC only, or CT-P13 only, or with RMC switched to CT-P13. Additionally, 28 IFX-naïve patients were assayed as controls. In total, 180 samples were analyzed. ATI trough levels were measured in parallel with 3 different bridging Enzyme Linked Immunosorbent Assays constructed using the 3 drugs. Spearman's coefficient and percentages of agreement were used to study the correlation between each assay.</p> <p>Results:</p> <p>In total, 76 samples out of 152 IFX-treated patient samples were ATI-positive (30 RMC, 14 CT-P13, and 32 switchers). All resulted ATI-positive when either CT-P13 or SB2 bridging assays were used. The overall percentage of agreement was 100% when compared either with CT-P13 or SB2 assays. No significant differences were found among ATI levels and coefficients (Spearman's 0.98 to 1.0, P < 0.0001).</p> <p>Conclusions:</p> <p>ATI of RMC-treated, CT-P13-treated or RMC to CT-P13 switched patients show full cross-reactivity with CT-P13 and SB2. Findings suggest that immunodominant epitopes in the reference and CT-P13 drugs are equally present in SB2. Data support full interchangeability between biosimilars in regard to immunogenicity.</p>
Dataset related to article "'Quality of Care' Standards in Inflammatory Bowel Disease: A Systematic Review."
<p>This record contains raw data related to article " 'Quality of Care' Standards in Inflammatory Bowel Disease: A Systematic Review."</p> <p>Background:</p> <p>Inflammatory bowel disease [IBD] includes chronic, disabling and progressive conditions that need a complex approach and management. Although several attempts have been made to standardize the care of IBD patients, no clear definitions of a global 'standard of care' are currently available.</p> <p>Methods:</p> <p>We performed a systematic review of the available literature, searching for all relevant data concerning three main domains of standards of quality of care in IBD patients: structure, process and outcomes. From the literature search, 2394 abstracts were retrieved, and 62 relevant papers were included in the final review.</p> <p>Results:</p> <p>Standards of quality of care in IBD include several aspects that can be summarized in three identified domains: structure, process and outcomes. The suggested structure of an IBD Unit includes a multi-disciplinary approach, effective referral processes, improved access using helplines, and departmental guidelines/pathways with identification of measurable quality indicators. Coordinated care models which incorporate a multi-disciplinary approach, structured clinical pathways or processes for the diagnosis, monitoring and treatment of IBD, fast-track recovery from IBD surgery, designated IBD clinics, virtual clinics and telemanagement are currently considered the main standards for process, although supporting data are limited. Several consensus statements on outcomes and quality indicators have been reported, focusing on outcomes in symptoms, function and quality of life restoration, survival and disease control, in addition to effective healthcare utilization.</p> <p>Conclusions:</p> <p>The results of this systematic review can provide the basis for general recommendations for standards of quality of care in IBD.</p>
Expression of the mannose receptor (CD206) defines distinct populations of human colonic macrophages in health and inflammatory bowel disease
GEO Series GSE124350. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Inflammatory bowel disease (HG-U133B)
GEO Series GSE1142. Homo sapiens. 6 samples. Type: Expression profiling by array.
SWI/SNF chromatin-remodeling factor BAF60b restrains inflammatory diseases by affecting regulatory T cells migration [ATAC-Seq]
GEO Series GSE267288. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Familial dominant diarrhea caused by an activating GUCY2C mutation is also associated with inflammatory bowel disease
GEO Series GSE31260. Homo sapiens. 25 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
DATASET RELATED TO ARTICLE "The Alpha-Synuclein RT-QuIC Products Generated by the Olfactory Mucosa of Patients with Parkinson's Disease and Multiple System Atrophy Induce Inflammatory Responses in SH-SY5Y Cells"
<p>RAW DATA RELATED TO ARTICLE AT TITLE</p>
Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases
<p>This directory contains custom codes and supplementary datasets generated for the study "Investigating the shared genetic architecture between multiple sclerosis and inflammatory bowel diseases".</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.