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29,897 results for “Activities”
Differences in Chemo-signaling Compound-Evoked Brain Activity in Male and Female Young Adults: A Pilot Study in the Role of Sexual Dimorphism in Olfactory Chemo-Signaling
Open the record for dataset details and reuse information.
BIDS Data for "A Whole-Brain Map and Assay Parameter Analysis of Mouse VTA Dopaminergic Activation"
<p>Base data package for the “"A Whole-Brain Map and Assay Parameter Analysis of Mouse VTA Dopaminergic Activation” article, formatted corresponding to the Brain Imaging Data Structure.</p>
Measurement of 139La(p,x) cross sections from 35-60 MeV by stacked-target activation
<p>This repository contains all raw gamma-ray spectra analyzed for the present manuscript, as well as calibration spectra. Further details and analysis code are available on reasonable request. </p> <p>A stacked-target of natural lanthanum foils (99.9119% 139La) was irradiated using a 60 MeV proton beam at the LBNL 88-Inch Cyclotron. 139La(p,x) cross sections are reported between 35–60 MeV for nine product radionuclides. The primary motivation for this measurement was the need to quantify the production of 134Ce. As a positron-emitting analogue of the promising medical radionuclide 225Ac, 134Ce is desirable for in vivo applications of bio-distribution assays for this emerging radio-pharmaceutical. The results of this measurement were compared to the nuclear model codes TALYS, EMPIRE and ALICE (using default parameters), which showed significant deviation from the measured values.</p>
Supplementary data for "Machine learning-based prediction of activity and substrate specificity for OleA enzymes in the thiolase superfamily"
<p>Supplementary data for "Machine learning-based prediction of activity and substrate specificity for OleA enzymes in the thiolase superfamily"</p>
CHAMP and Swarm solar activity- and height-scaled polar cap plasma density measurements
<p>Solar activity- and height-adjusted plasma density measurements in the polar cap (i.e., above 80° latitude in Modified Apex<sub>110</sub> coordinates) from the Swarm and CHAMP satellites. covering the entire CHAMP mission period (2002–2009) and the Swarm mission period from launch through February 2020.</p> <p>Plasma density measurements are scaled to a nominal solar activity level of <<em>F</em>10.7><sub>27</sub> = 80 sfu, and an altitude of 500 km, as described in Hatch et al. (submitted to JGR: Space Physics; <a href="https://www.essoar.org/doi/abs/10.1002/essoar.10502854.1">ESSOAr pre-print</a>) </p> <p>This dataset was prepared as a part of the "Swarm+ Coupling High-Low Atmosphere Interactions: Ion Outflow" project (<a href="https://swarmoutflow.w.uib.no/">project website</a>) (<a href="https://eo4society.esa.int/projects/swarm-coupling-high-low-atmosphere-interactions-ion-outflow/">ESA website</a>), and is funded by European Space Agency Contract #4000126731.</p> <p>Data are stored in HDF5 format as a Python Pandas dataframe. They can be loaded into Python via the following.</p> <pre><code class="language-python">import pandas as pd df = pd.read_hdf('CHAMP_Swarm_polarcap_adjDensity.hdf',key='df')</code></pre> <p>The data columns are</p> <ul> <li>'NeAdj' : Solar activity- and height-adjusted plasma density (cm<sup>-3</sup>)</li> <li>'a110lat' : Modified Apex<sub>110</sub> latitude (deg)</li> <li>'a110lon' : Modified Apex<sub>110</sub> longitude (deg)</li> <li>'mlt' : Modified Apex<sub>110</sub> magnetic local time</li> <li>'h_km' : satellite altitude (km)</li> <li>'gclat' : geocentric latitude (deg)</li> <li>'gclon' : geocentric longitude (deg)</li> <li>'sat' : satellite identifier (string, one of 'A', 'B',' 'C', or 'CHAMP')</li> </ul>
Supplementary data for the manuscript "Technical note: Estimating aqueous solubilities and activity coefficients of mono- and α,ω-dicarboxylic acids using COSMO-RS-DARE"
<p>.cosmo files (BP-TZVPD-FINE) of dicarboxylic acids (C2-C8), dimers and monohydrates of mono- (C1-C6) and dicarboxylic acids, and water dimer.</p>
Data supplement for "Bifurcations of front motion in passive and active Allen-Cahn-type equations"
<p>This dataset contains the data and source files for figures 5 and 7-10 in the following publication: </p> <p>F. Stegemerten, S.V. Gurevich, U. Thiele</p> <p><em>'Bifurcations of front motion in passive and active Allen–Cahn-type equations' </em></p> <p>published in 2020 in CHAOS.</p> <p>Please follow the instructions given in 'Readme.txt'.</p>
Dataset for "Helicity proxies from linear polarisation of solar active regions"
<p>The <span class="math-tex">\(\alpha\)</span> effect is believed to play a key role in the generation of the solar magnetic field. A fundamental test for its significance in the solar dynamo is to look for magnetic helicity of opposite signs in the two hemispheres, and at small and large scales. However, measuring magnetic helicity is compromised by the inability to fully infer the magnetic field vector from observations of solar spectra, caused by what is known as the <span class="math-tex">\(\pi\)</span> ambiguity of spectropolarimetric observations. We decompose linear polarisation into parity-even and parity-odd <em>E</em> and <em>B</em> polarisations, which are not affected by the <span class="math-tex">\(\pi \)</span> ambiguity. Furthermore, we study whether the correlations of spatial Fourier spectra of <em>B</em> and parity-even quantities such as <em>E </em>or temperature <em>T</em> are a robust proxy for magnetic helicity of solar magnetic fields. We analyse polarisation measurements of active regions observed by the Helioseismic and Magnetic Imager on board the Solar Dynamics observatory. Theory predicts the magnetic helicity of active regions to have, statistically, opposite signs in the two hemispheres. We then compute the parity-odd <em>EB</em> and <em>TB</em> correlations, and test for systematic preference of their sign based on the hemisphere of the active regions. We find that: (i) <em>EB</em> and <em>TB</em> correlations are a reliable proxy for magnetic helicity, when computed from linear polarisation measurements away from spectral line cores, and (ii) <em>E</em> polarisation reverses its sign close to the line core. Our analysis reveals Faraday rotation to not have a significant influence on the computed parity-odd correlations. The <em>EB</em> decomposition of linear polarisation appears to be a good proxy for magnetic helicity independent of the <span class="math-tex">\(\pi\)</span> ambiguity. This allows us to routinely infer magnetic helicity directly from polarisation measurements.</p> <p>The full article can be found at https://arxiv.org/abs/2001.10884</p>
Demonstration of 100 Gbit/s active measurements in dynamically provisioned optical paths
<p>New techniques, based on Software-Defined Networks, are used to deploy optical paths dynamically. This demonstration shows how active measurements at 100 Gbit/s are performed to check before operation that the performance requirements are met in terms of capacity, delay or packet loss.</p>
The datasets used in the manuscript named "Dynamical Seasonal Prediction of Tropical Cyclone Activity Using a Global Ensemble Prediction System FGOALS-f2 V1.0"
<p>The hindcast and real-time prediction output of FGOALS-f2 V1.0 used in the study named "Dynamical Seasonal Prediction of Tropical Cyclone Activity Using a Global Ensemble Prediction System FGOALS-f2 V1.0"</p>
Systematic Data Analysis and Diagnostic Machine Learning Reveal Differences between Compounds with Single- and Multitarget Activity
<p>The deposited files contain balanced data sets of multi-target (MT) and single-target (ST) compounds (CPDs) used for machine learning studies (https://dx.doi.org/10.1021/acs.molpharmaceut.0c00901). The first file (st_mt_data.tsv) contains 15,142 MT- and 15,081 ST-CPDs and the second (st_dt_data.tsv) 1828 DT- and 1776 ST-CPDs. For each CPD, a nonstereo_aromatic_SMILES representation, the original ChEMBL_cid, UniProt (target) IDs, and CPD category (CPD_CAT) (i.e. DT/MT/ST) is provided. DT stands for 'diverse-target' and denotes a subset of MT-CPDs (as detailed in the publication). In addition, a CPD is tagged “Y” if it continued to be present in the data set after removal of 50% randomly selected CPDs or 50% CPD nearest neighbors (NN), respectively.</p>
Phenology data set of plants and birds and other taxonomic groups, as well as agrarian activities and abiotic phenomena from Latvia, 1970-2018
<p>A data set of phenological observations of plants, birds, as well as agrarian activities and abiotic phenomena from Latvia, 1970-2018 is presented. The data include limited number of observations of insects, amphibians, mammals, mushrooms, mollusks and fishes as well. The data was collected by voluntary observers (citizen scientists) and published as paper based yearly bulletins. It includes almost 48 000 individual observations of 159 different phenological phases from 103 locations in Latvia. Each entry is comprised of following fields:</p> <ol> <li>Station: name of the observation station</li> <li>Year: year of observation</li> <li>Season: season of observation as indicated in the primary publication</li> <li>Species: English name of the species observed or description of phenomena observed in case of abiotic occurrences</li> <li>Species Latin: Latine name of the species observed</li> <li>Taxonomic_group: taxonomic group of the species observed or grouping of non-biological phases (“Abiotic” for meteorological phenomena and “Agrarian” for agrarian activities)</li> <li>Phenophase: description of phenological phase observed</li> <li>BBCH: attributed BBCH code for phenological phase observed, where applicable</li> <li>Date: date of the first observation of the phase</li> <li>DoY: day of the year of the first observation of the phase</li> <li>Implausible: flag indicating of the reported date of phenological phase is highly implausible (TRUE) or realistic (FALSE)</li> <li>Wrong_order: flag indicating if the order of the reported phases at a given station and year is not realistic (TRUE) or realistic (FALSE)</li> </ol>
Human Hyperpolarization Activated Cyclic Nucleotide Gated Ion Channel 4 (HCN4); A Target Enabling Package
<p>HCN4 is one of four hyperpolarisation activated cyclic nucleotide gated ion channels. It is responsible for the pacemaker or funny (If) current in the heart and is required for maintenance of a stable heartbeat. Mutations in HCN4 lead to a number of arrhythmias. HCN4 is the target for the angina drug ivabradine, which reduces HCN4 activity. However, ivabradine is non-selective, affecting all of the four HCN channels. HCN4 is a close homologue of HCN2, which is a target for neuropathic and inflammatory pain treatment. We have solved the structure of HCN4 both in complex with cyclic AMP and without nucleotide. Comparison of our HCN4 structure with that of the related HCN1 channel (86% identity) allows us to suggest ways to design selectivity for small molecule inhibitors between these closely related channels. </p>
Data set for "Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing"
<p>Data set for: Gasselin C, Hohl B, Vernet A, Crochet C, Petersen CCH (2021) Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing. Neuron doi: 10.1016/j.neuron.2020.12.018</p> <p>There are 2 files in this upload:</p> <p>1. The file named "2021_Gasselin_Neuron.pdf" is the Open Access pdf of the online publication in Neuron.</p> <p>2. The file named "Gasselin_data_code.zip" (~9 GB) is a zipped version of a folder "Gasselin_data_code" (~13 GB), which contains the data analysed in the study along with the Matlab code used to generate the published figures. To access the data and the code, first unzip the file. Then add the folder with subfolders to the Matlab path and run the different codes. The current folder must be the main folder (‘Gasselin_data_code’). Each code computes and plots the results used in the corresponding figure. Figures and Tables are saved in the subfolder ‘Figures’.</p> <p>The subfolder ‘Functions’ contains functions called by the main codes.</p> <p>The main folder contains the following codes:</p> <p><em>Gasselin_Figure1: computes and plots the results for the panels D, E and F of figure 1.</em></p> <p><em>Gasselin_Figure2: computes and plots the results for the panels B and C of figure 2.</em></p> <p><em>Gasselin_Figure3: computes and plots the results for the panels B, C and D of figure 3.</em></p> <p><em>Gasselin_Figure4: computes and plots the results for the panels A, B and C of figure 4.</em></p> <p><em>Gasselin_FigureS1: computes and plots the results for the panels A, B and C of figure S1.</em></p> <p><em>Gasselin_FigureS2: computes and plots the results for the panels A and B of figure S2.</em></p> <p> </p> <p>The subfolder ‘Data’ contains the data structures used for the different figures:</p> <p><em>data_figure1.mat</em></p> <p><em>data_figure2.mat</em></p> <p><em>data_figure3.mat</em></p> <p><em>data_figure4_MECA.mat</em></p> <p><em>data_figure4_Activation.mat</em></p> <p><em>data_figure4_Inactivation.mat</em></p> <p><em>data_figureS2_Activation.mat</em></p> <p><em>data_figureS2_Inactivation.mat</em></p> <p><em>data_Axon.mat</em></p> <p> </p> <p>The data structures contain the following fields:</p> <p><em>Mouse_Name</em> : name of the mouse.</p> <p><em>Mouse_DateOfBirth</em>: date of birth of the mouse (YMD).</p> <p><em>Mouse_Sex</em>: sex of the mouse (F or M).</p> <p><em>Mouse_Genotype</em>: genotype of the mouse.</p> <p><em>Mouse_Drug</em>: experimental condition of the recording (control = ‘No Drug’; blockade of glutamatergic transmission = ‘CNQX_DAPV’; blockade of glutamatergic transmission and nicotinic receptors = ‘CNQX_DAPV_MECA’; blockade of nicotinic receptors only = ‘MECA’).</p> <p><em>Mouse_Virus</em>: virus injected if any.</p> <p><em>Cell_Counter</em>; cell recorded in a given mouse.</p> <p><em>Cell_Type</em>: type of the recorded cell based on 2P imaging. (EXC, VIP, PV, SST, 5HT3aR_non_VIP).</p> <p><em>Cell_Depth</em>: depth of the recorded cell relative to pia (µm).</p> <p><em>Cell_TargetedBrainArea</em>: cortical area targeted (C2 column of the barrel cortex = C2).</p> <p><em>Cell_Fluorescence</em>: expression of the genetically encoded fluorophore (FALSE or TRUE). A neuron recorded in a VIP_IRES_Cre x LSL_tdTomato (cf <em>Mouse_Genotype</em>) with <em>Cell_Fluorescence</em>=TRUE is considered as a VIP neuron (cf <em>Cell_Type</em>).</p> <p><em>Sweep_Counter</em>: number of the sweep recorded for a given neuron (data were acquired across successive continuous sweeps of 30-60 s).</p> <p><em>Sweep_Type</em>: experimental condition during that sweep (Only spontaneous whisking onset = ‘Onset’; Whisking onset and whisker stimulus = ‘Onset_Whisker_Stim’ ; Optogenetic stimulation = ‘Opto_Stim’; Optogenetic activation = ‘Opto_Activation’; Optogenetic inactivation = ‘Opto_Inactivation’; ).</p> <p><em>Sweep_Start_Time</em>: time at the beginning of the sweep recording (YMDHms).</p> <p><em>Sweep_WhiskerAngle</em>: C2 whisker angular position extracted from simultaneous high-speed video filming (deg).</p> <p><em>Sweep_WhiskerAngle_SamplingRate</em>: sampling rate of the whisker angle trace.</p> <p><em>Sweep_WhiskingOnset_Time</em>: time of identified whisking onset - excluding any whisker stimulus shortly before or after (s).</p> <p><em>Sweep_MembranePotential</em>: membrane potential recording (mV) after cutting of the APs.</p> <p><em>Sweep_MembranePotential_SamplingRate</em>: sampling rate of the membrane potential signal (pt.s<sup>-1</sup>).</p> <p><em>Sweep_CurrentInjected</em>: current injected into the cell (pA).</p> <p><em>Sweep_CurrentInjected_SamplingRate</em>: sampling rate of current signal (pt.s<sup>-1</sup>).</p> <p><em>Sweep_WhiskerStim_Name</em>: whisker to which the magnetic stimulus was applied to (C2 or B2&C2).</p> <p><em>Sweep_WhiskerStim_Time</em>: onset times of the whisker stimulus (s).</p> <p><em>Sweep_OptoStim_Power</em>: light power applied for optogenetic manipulations (% of the max power).</p> <p><em>Sweep_OptoStim_Time</em>: onset times of the light pulses for optogenetic manipulations (s).</p> <p><em>Cell_ID</em>: unique cell identifier (= <em>Mouse_Name</em>+<em>Cell_Counter</em>).</p> <p><em>SpikeThreshold</em>: spike threshold used to detect APs (mV).</p> <p><em>Trial_WhiskingOnset</em>: data structure containing the cut signals used to compute averaged responses around whisking onset times.</p> <p><em>Trial_WhiskerStim</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times.</p> <p><em>Trial_WhiskerStim_QuietTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials without whisker movements.</p> <p><em>Trial_WhiskerStim_WhiskingTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials with whisker movements.</p> <p><em>Trial_Opto</em>: data structure containing the cut signals used to compute averaged responses around optogenetic stimulus onset times.</p> <p><em>Trial_OptoAndWhisker_QuietTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials with optogenetic manipulation and no whisker movements.</p> <p><em>Trial_OptoAndWhisker_WhiskingTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials with optogenetic manipulation and with whisker movements.</p> <p><em>Trial_OnlyWhisker_QuietTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials without optogenetic manipulation and without whisker movements.</p> <p><em>Trial_OnlyWhisker_WhiskingTrials</em>: data structure containing the cut signals used to compute averaged responses around whisker stimulus onset times for trials without optogenetic manipulation and with whisker movements.</p> <p><em>Trial_OnlyOpto</em>: data structure containing the cut signals used to compute averaged responses around optogenetic stimulus onset times in trials without whisker stimulus.</p>
Image captioning dataset for human activities
<p>An image captioning dataset including images of humans performing various activities. The included images include the following activities: <code>walking, running, sleeping, swimming, sitting, jumping, riding, climbing, drinking and reading.</code></p>
MOSID (Microcontroller On-chip Sensor IDentification): A dataset of readings from the internal monitoring sensors of STM32L152RTXX microcontrollers during the stimulation of their electronic activity
<p>The MOSID (Microcontroller On-chip Sensor IDentification) dataset consists of 5 acquired data subsets (6,72 GB total, compressed into 560 MB), each collected during different experiments and periods using various equipment (HMP4040, DF1731SB & HM305) and acquisition strategies. These subsets contain readings from the temperature and voltage sensors embedded in 20 STM32L-DISCOVERY devices. The data was captured during the execution of 5 different workloads as stimuli, repeated over 20 iterations. The stimuli employed are as follows:</p><ol><li>20x20 Long-type matrix product.</li><li>20x20 Float-type matrix product.</li><li>Algorithm for ascending sorting, Bubble Sort.</li><li>Algorithm for 2D-point clustering, Convex Hull.</li><li>Encryption algorithm AES 128-bit.</li></ol><p>The subsets are structured according to the folder format "X_Y," where X is the manually assigned number to the board, and Y is the corresponding number for the executed algorithm. Within each of these folders, files are present in the format "data_Z.txt," where Z represents the iteration number to which the file belongs. In total, the dataset comprises 9600 files with a final size of approximately 7 GB. The different presented subsets are as follows:</p><ul><li>ACQ1: Derived from the experiment named "Automatic Acquisition 1 (HMP4040)" conducted using a daisy-chain topology (20 out of 20 boards, 2000 files).</li><li>ACQ2: Derived from the experiment named "Automatic Acquisition 2 (HMP4040)" conducted using a daisy-chain topology (20 out of 20 boards, 2000 files).</li><li>ACQ3: Derived from the experiment named "Individual Acquisitions (HMP4040)", performed board by board from idle conditions (20 out of 20 boards, 2000 files).</li><li>ACQ4: Derived from the experiment named "GOLD SOURCE DF1731SB Acquisitions" conducted using a partial daisy-chain setup (2 devices at a time, 18 out of 20 boards excluding boards , 1800 files).</li><li>ACQ5: Derived from the experiment named "HANMATEK HM305 Acquisitions" conducted using a partial daisy-chain setup (2 devices at a time, 18 out of 20 boards, 1800 files).</li></ul><p>In each "data_Z.txt" file, starting from the 5th line, temperature and voltage raw ADC conversions from the sensors are provided, captured during the execution of the stimulus in successive lines. Additionally, a table (Table_UIDS.csv) with metadata for each of the boards used in the experiments is included, which is needed in order to normalize the data in terms of ºC and Volts.</p><ul><li>BOARD_NUM, which contains the manually assigned board number.</li><li>UID, which contains the Unique Identifier of the board assigned by the manufacturer.</li><li>T_CAL_1, which holds the calibration value of the board's temperature sensor at 30ºC.</li><li>T_CAL_2, which holds the calibration value of the board's temperature sensor at 100ºC.</li><li>VREFINT_CAL, which contains the calibration value of the board's voltage sensor.</li></ul>
Dataset: Temporal recalibration in response to delayed visual feedback of active versus passive actions
<p>Data set related to the manuscript: </p><p>Kufer, K., Schmitter, C. V, Kircher, T., Straube, B., 2023. Temporal recalibration in response to delayed visual feedback of active versus passive actions: An fMRI study. https://doi.org/10.21203/RS.3.RS-3493865/V1</p><p>Abstract:</p><p>The brain can adapt its expectations about the relative timing of actions and their sensory outcomes in a process known as temporal recalibration. This might occur as the recalibration of timing between the outcome and (1) the motor act (sensorimotor) or (2) tactile/proprioceptive information (inter-sensory). This fMRI recalibration study investigated sensorimotor contributions to temporal recalibration by comparing active and passive conditions. Subjects were repeatedly exposed to delayed (150ms) or undelayed visual stimuli, triggered by active or passive button presses. Recalibration effects were tested in delay detection tasks, including visual and auditory outcomes. We showed that both modalities were affected by visual recalibration. However, an active advantage was observed only in visual conditions. Recalibration was generally associated with the left cerebellum (lobules IV, V and vermis) while action related activation (active > passive) occurred in the right middle/superior frontal gyrus during adaptation and test phases. Recalibration transferred from vision to audition was related to action specic activations in the cingulate cortex, the angular gyrus and left inferior frontal gyrus. Our data provide new insights in sensorimotor contributions to temporal recalibration via the superior frontal gyrus and inter-sensory contributions mediated by the cerebellum.</p>
In vivo treatment with insulin-like growth factor 1 reduces CCR5 expression on vaccine-induced activated CD4+ T-cells
<p>Dataset of the publication "In vivo treatment with insulin-like growth factor 1 reduces CCR5 expression on vaccine-induced activated CD4+ T-cells" by Bissa et al. on the journal Vaccines. </p><p>Each folder contains the original files reporting the data used to generate the manuscript.</p><p>For flowcytometry based assays the Flow panel is included in the folders. </p><p>For ELISA based assays the schemes of the plates are included in the folders. </p><p>The excel table "Bissa et al._Vaccines_2023_Animal IDs and viral acquisition" reports the IDs and grouping of the animals together with their viral acquisition</p><p>The excel table "Bissa et al._Vaccines_2023_Master table" reports each data used to generate the figures and supplemental materials included in the publication </p>
Accompanying dataset; 'Agroforestry enhances biological activity, diversity and soil-based ecosystem functions in mountain agroecosystems of Latin America: A meta-analysis.'
<p>The database created as part of the meta-analysis is designed to facilitate the comparison of biological activity, diversity (BIAD), and ecosystem functions (EFs) between agroforestry systems (AFS) and other land-use types. It incorporates data extracted from selected studies, each record comprising a mean value, sample size, and a variance measure to compute standard deviation. The database also categorizes data according to 22 explanatory variables, including geographical coordinates, climate classification, soil type, AFS classification, and more, to characterize the sites and management systems involved. This detailed classification enables a nuanced analysis of how different factors might influence the BIAD and EFs in the context of AFS. The database supports the meta-analysis by allowing for the estimation of effect sizes using response ratios, which compare the relative difference in BIAD and EFs between AFS and other land uses. Data extraction from primary studies was meticulous, employing both direct and indirect methods such as graph digitizing software, and missing data were supplemented using reliable sources or direct communication with the original study authors. The comprehensive nature of this database ensures that the analysis can account for a wide range of variables that may affect the outcomes of interest in the meta-analysis. </p><p>For an in-depth exploration of the study's findings and methodology, refer to the comprehensive meta-analysis available in Global Change Biology (2024), entitled "<i>Agroforestry Enhances Biological Activity, Diversity, and Soil-Based Ecosystem Functions in Mountain Agroecosystems of Latin America: A Meta-Analysis</i>."</p>
Data from: Chronic Rapamycin administration via drinking water mitigates the pathological phenotype in a Krabbe disease mouse model through autophagy activation.
<p>ABSTRACT </p><p>Krabbe disease (KD) is a rare disorder caused by a deficiency of the lysosomal enzyme galactosylceramidase (GALC), resulting in the accumulation of the cytotoxic metabolite psychosine (PSY) in the nervous system. This accumulation triggers demyelination and neurodegeneration. Despite ongoing research, the underlying pathogenic mechanisms remain incompletely understood, and there is currently no cure available.</p><p>Previous studies from our lab revealed the presence of autophagy dysfunctions in KD pathogenesis, as evidenced by the presence of p62-tagged protein aggregates in the brains of KD mice and increased p62 levels in the KD sciatic nerve. We also demonstrated that the autophagy inducer Rapamycin (RAPA) can partially restore the wild-type (WT) phenotype in KD primary cells by reducing the number of p62 aggregates.</p><p>In this study, we tested RAPA in the Twitcher (TWI) mouse, a spontaneous KD mouse model. We administered the drug ad libitum via drinking water (15 mg/L) starting from post-natal day (PND) 21-23. We longitudinally monitored the motor performance of the mice through grip strength and rotarod tests, along with various biochemical parameters related to KD pathogenesis (i.e. autophagy markers expression, myelination, astrogliosis, and PSY accumulation).</p><p>Our findings demonstrate that RAPA significantly enhances motor functions at specific treatment time points and reduces astrogliosis in TWI brain, spinal cord, and sciatic nerves. Using western blot and immunohistochemistry, we observed a decrease in p62 aggregates in TWI nervous tissues, which corroborates our earlier in-vitro results. Furthermore, RAPA treatment partially reduces PSY levels in the spinal cord.</p><p>In conclusion, our results support the consideration of RAPA as a supportive therapy for KD. Importantly, as RAPA is already available in pharmaceutical formulations for clinical use, its potential for KD treatment can be promptly evaluated in clinical trials.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.