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Dataset results
265 results for “Aromatase inhibitors”
mRNA-seq of gonads from adult zebrafish treated with aromatase inhibitor and control
GEO Series GSE123439. Danio rerio. 16 samples. Type: Expression profiling by high throughput sequencing.
Molecular profiling of aromatase inhibitor-treated post-menopausal breast tumors identifies immunerelated correlates of resistance
GEO Series GSE153470. Homo sapiens. 162 samples. Type: Expression profiling by array.
Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients
GEO Series GSE126870. Homo sapiens. 178 samples. Type: Expression profiling by array.
FOXA1 Shapes the Chromatin State of ILC and Drives Differential Response to Aromatase Inhibitors and Tamoxifen [HiChIP-seq]
GEO Series GSE152366. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Development and validation of multivariate predictors of primary endocrine resistance to tamoxifen and aromatase inhibitors in luminal breast cancer reveal drug-specific differences [HumanMethylationE
GEO Series GSE274415. Homo sapiens. 176 samples. Type: Methylation profiling by genome tiling array.
Data from: Higher insulin resistance & adiposity in post-menopausal women with breast cancer treated with aromatase inhibitors
Context: Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy in post-menopausal breast cancer. Objective: We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer. Design: Case-control study Setting: University teaching hospital Participants: 20 post-menopausal breast cancer patients, treated with aromatase inhibitor and 20 age-matched controls. Main outcome measures: Primary outcome measure was insulin sensitivity index – Matsuda, derived from a 75g oral glucose tolerance test. Body composition was assessed by DEXA and subcutaneous adipose tissue biopsies obtained for assessment of mRNA transcript levels. Data are mean ± SEM (inhibitor vs controls). Results: Aromatase inhibitor therapy was associated with significantly lower insulin sensitivity (5.15 ± 0.45 vs. 6.80 ± 0.64, P = 0.041), higher peak insulin concentration following OGTT (693.4 ± 78.6 vs. 527.6 ± 85.5 pmol/L, P = 0.035), greater percentage body fat (38.4 ± 1.0 vs. 34.6 ± 1.3 %, P = 0.026), and higher plasma leptin concentration (23.5 ± 2.8 vs. 15.5 ± 2.3 ng/mL, P = 0.035). Conclusions: Women who received aromatase inhibitors for post-menopausal breast cancer have greater percentage body fat and insulin resistance compared to controls with no history of breast cancer.
A Prospective Assessment of Loss of Grip Strength by Baseline BMI in Breast Cancer Patients Receiving Adjuvant Aromatase Inhibitors and Tamoxifen
ClinicalTrials.gov study NCT01223833. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace)
ClinicalTrials.gov study NCT01908556. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage
ClinicalTrials.gov study NCT07109947. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Adherence of Hispanic / Latina Breast Cancer - Patients to Adjuvant Aromatase Inhibitors
ClinicalTrials.gov study NCT03144037. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gefitinib in Treating Patients With Metastatic Breast Cancer That Has Progressed After Antiestrogen and Nonsteroidal Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT00066339. IPD Sharing: Not stated. Countries: 1. Publications: 0.
SAKK - a Trial to Evaluate Antitumor Efficacy of Faslodex® After Aromatase Inhibitor Failure in Advanced Breast Cancer
ClinicalTrials.gov study NCT00272740. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Longitudinal Assessment of Arthralgia and Related Symptoms in Breast Cancer Patients Receiving Aromatase Inhibitors
ClinicalTrials.gov study NCT00738998. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparative Effectiveness of Acupuncture and Nonsteroidal Anti-inflammatory Drugs for the Management of Aromatase Inhibitor Induced Arthralgia Among Breast Cancer Survivors
ClinicalTrials.gov study NCT04511832. IPD Sharing: Not stated. Countries: 1. Publications: 0.
NEOADjuvant Aromatase Inhibitor and Pertuzumab/Trastuzumab for Women With Breast Cancer
ClinicalTrials.gov study NCT02689921. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Yoga for Aromatase Inhibitor-associated Joint Pain
ClinicalTrials.gov study NCT01951976. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Drug Withdrawal in Women With Progressive Breast Cancer While on Aromatase Inhibitor Therapy
ClinicalTrials.gov study NCT00916162. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Obesity on the Efficacy of Endocrine Therapy With Aromatase Inhibitors
ClinicalTrials.gov study NCT01758146. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluating the Efficacy of Structured Exercise Interventions in Alleviating Aromatase Inhibitor-Induced Arthralgia in Breast Cancer Survivors: a Pilot Study Protocol
ClinicalTrials.gov study NCT06754293. IPD Sharing: NO. Countries: 1. Publications: 0.
Oral Aromatase Inhibitors Modify the Gut Microbiome
ClinicalTrials.gov study NCT05030038. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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