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126
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ShareScore release 0.9.0
Dataset results
126 results for “BDNF”
Expression data from C17.2 progenitor cells during neural differentiation for 5 and 10 days with NGF and BDNF
GEO Series GSE97337. Mus musculus. 9 samples. Type: Expression profiling by array.
YTHDF2 mediates the action of BDNF stimulating proliferation of porcine follicle granulosa cells
GEO Series GSE247561. Sus scrofa. 4 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article "Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype"
<p>This record contains raw data related to the article "Impact of BDNF Val66Met Polymorphism on Myocardial Infarction: Exploring the Macrophage Phenotype"</p>
Dataset related to the article-BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice
<p>This record contains raw data related to the article "BDNF Val66Met polymorphism alters food intake and hypothalamic BDNF expression in mice"</p> <p>Abstract</p> <p>Obesity, a rising public health burden, is a multifactorial disease with an increased risk for patients to develop several pathological conditions including type 2 diabetes mellitus, hypertension, and cardiovascular disease. Increasing evidence suggests a relationship between the human brain‐derived neurotrophic factor (BDNF) Val66Met single‐nucleotide polymorphism (SNP) and obesity, although the underlying mechanisms of this connection are still not completely understood. In the present study, we found that homozygous knock‐in BDNFMet/Met mice were overweight and hyperphagic compared to wildtype BDNFVal/Val mice. Increased food intake was associated with reduction of total BDNF and BDNF1, BDNF4 and BDNF6 transcripts in the hypothalamus of BDNFMet/Met mice. In contrast, in the white adipose tissue total BDNF and Glut4 expression levels were augmented, while sirtuin 1 and leptin receptor (Ob‐R) expression levels were reduced in BDNFMet/Met mice. Moreover, plasmatic leptin levels were decreased in BDNFMet/Met mice. However, BDNFVal/Val and BDNFMet/Met mice showed a similar response to the insulin tolerance test and glucose tolerance test. Altogether, these results suggest that BDNF Val66Met SNP strongly contributes to adipose tissue pathophysiology, resulting in reduced circulating leptin levels and hypothalamic expression of BDNF, which, in turn, promote increased food intake and overweight in BDNFMet/Met mice.</p>
Dataset related to the article "Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology"
<p>This record contains raw data related to the article "Potential Relation between Plasma BDNF Levels and Human Coronary Plaque Morphology"</p>
Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation and negative emotionality
<p>This database includes the raw data linked with the paper “Sex-dimorphic pathways in the associations between maternal trait anxiety, infant BDNF methylation and negative emotionality” accepted for publication on Development and Psychopathology. This study is part of the longitudinal and multi-centric “Measuring the outcomes of maternal COVID-19-related prenatal exposure (MOM-COPE)” study. Here, we report on the sex-dependent effects of antenatal exposure to maternal anxiety on infants’ methylation levels of the BDNF gene at birth and on negative emotionality trajectories from 3 to 6 months of age.</p> <p>Procedures</p> <p>Mother–infant dyads (N = 276) were recruited at delivery. Maternal trait anxiety, as a marker of antenatal chronic stress exposure, was assessed soon after delivery using the Stait-Trait Anxiety Inventory (STAI-Y). Infants’ BDNF DNAm at birth was assessed in 11 CpG sites in buccal cells whereas infants’ NE was assessed at 3 (N = 225) and 6 months (N = 189) using the Infant Behavior Questionnaire-Revised (IBQ-R).</p> <p>Analytical plan</p> <p>Principal component analysis (PCA) was used to reduce the number of CpG sites into a smaller set of factors. The PCA yielded 2 principal components: PC1 (composed of 6 CpG sites) and PC2 (composed of 5 CpG sites). Separate hierarchical regression analyses were performed to evaluate the independent and interactive effects of infant gender and maternal anxiety on infant methylation levels.</p> <p>Hierarchical linear models (HLMs) were performed to investigate sex-dimorphic associations between infant NE trajectory from 3 to 6 months and maternal trait anxiety or infant BDNF methylation.</p> <p>Findings in brief</p> <p>Higher maternal antenatal anxiety was associated with greater 6-month-olds’ NE. Furthermore, maternal antenatal anxiety predicted greater infants’ BDNF methylation in five CpG sites in males but not in females. Higher methylation at these sites was associated with greater 3-to-6-month NE increase, independently of infants’ sex.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.